General Structure Information
| PDB ID | 1zr0 |
| HGNC Gene Label(s) | TFPI2 |
| Structure Name | crystal structure of kunitz domain 1 of tissue factor pathway inhibitor-2 with bovine trypsin |
| Resolution | 1.8Å |
| Reference | AUTH A.E.SCHMIDT,H.S.CHAND,D.CASCIO,W.KISIEL,S.P.BAJAJTITL CRYSTAL STRUCTURE OF KUNITZ DOMAIN 1 (KD1) OFTITL 2 TISSUE FACTOR PATHWAY INHIBITOR-2 IN COMPLEX WITHTITL 3 TRYPSIN. IMPLICATIONS FOR KD1 SPECIFICITY OFTITL 4 INHIBITIONREF J.BIOL.CHEM. V. 280 27832 2005REFN ISSN 0021-9258PMID 15932872DOI 10.1074/JBC.M504105200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 59 |
| Number Of SNVs | 21 |
| Number Of Permutations | 1375 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.386 |
| p-value | 0.312 |
COSMIC
| Number Of Residues | 59 |
| Number Of SNVs | 3 |
| Number Of Permutations | 75 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.333 |
| p-value | 0.397 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 21 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | -0.5 |
| p-value | 0.164 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
