General Structure Information
| PDB ID | 2ea2 |
| HGNC Gene Label(s) | METAP2 |
| Structure Name | h-metap2 complexed with a773812 |
| Resolution | 2.5Å |
| Reference | AUTH G.T.WANG,R.A.MANTEI,M.KAWAI,J.S.TEDROW,D.M.BARNES,AUTH 2 J.WANG,Q.ZHANG,P.LOU,L.A.GARCIA,J.BOUSKA,M.YATES,AUTH 3 C.PARK,R.A.JUDGE,R.LESNIEWSKI,G.S.SHEPPARD,R.L.BELLTITL LEAD OPTIMIZATION OF METHIONINE AMINOPEPTIDASE-2TITL 2 (METAP2) INHIBITORS CONTAINING SULFONAMIDES OFTITL 3 5,6-DISUBSTITUTED ANTHRANILIC ACIDSREF BIOORG.MED.CHEM.LETT. V. 17 2817 2007REFN ISSN 0960-894XPMID 17350258DOI 10.1016/J.BMCL.2007.02.062 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 369 |
| Number Of SNVs | 43 |
| Number Of Permutations | 7185 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.163 |
| p-value | 0.0 |