General Structure Information
| PDB ID | 3tl5 |
| HGNC Gene Label(s) | PIK3CG |
| Structure Name | discovery of gdc-0980: a potent, selective, and orally available class i phosphatidylinositol 3-kinase (pi3k)/mammalian target of rapamycin (mtor) kinase inhibitor for the treatment of cancer |
| Resolution | 2.79Å |
| Reference | AUTH D.P.SUTHERLIN,L.BAO,M.BERRY,G.CASTANEDO,I.CHUCKOWREE,AUTH 2 J.DOTSON,A.FOLKS,L.FRIEDMAN,R.GOLDSMITH,J.GUNZNER,T.HEFFRON,AUTH 3 J.LESNICK,C.LEWIS,S.MATHIEU,J.MURRAY,J.NONOMIYA,J.PANG,AUTH 4 N.PEGG,W.W.PRIOR,L.ROUGE,L.SALPHATI,D.SAMPATH,Q.TIAN,V.TSUI,AUTH 5 N.C.WAN,S.WANG,B.WEI,C.WIESMANN,P.WU,B.Y.ZHU,A.OLIVEROTITL DISCOVERY OF A POTENT, SELECTIVE, AND ORALLY AVAILABLE CLASSTITL 2 I PHOSPHATIDYLINOSITOL 3-KINASE (PI3K)/MAMMALIAN TARGET OFTITL 3 RAPAMYCIN (MTOR) KINASE INHIBITOR (GDC-0980) FOR THETITL 4 TREATMENT OF CANCER.REF J.MED.CHEM. V. 54 7579 2011REFN ISSN 0022-2623PMID 21981714DOI 10.1021/JM2009327 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 844 |
| Number Of SNVs | 194 |
| Number Of Permutations | 82675 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.006 |
| p-value | 0.929 |
COSMIC
| Number Of Residues | 844 |
| Number Of SNVs | 37 |
| Number Of Permutations | 49358 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.005 |
| p-value | 0.489 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 194 |
| Number Of COSMIC SNVs | 30 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.004 |
| p-value | 0.773 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 7:106508436 | rs137951629 | S>P | A:144 | (27.92, 19.85, 0.93) |
| 7:106508440 | E>G | A:145 | (26.03, 22.72, -2.58) | |
| 7:106508442 | rs200355499 | E>Q | A:146 | (23.38, 23.35, 1.10) |
| 7:106508452 | A>D | A:149 | (25.12, 27.67, 1.16) | |
| 7:106508455 | F>C | A:150 | (25.42, 27.05, 6.46) | |
| 7:106508461 | COSM3876999 | R>Q | A:152 | (27.72, 31.30, 0.35) |
| 7:106508480 | rs138562997 | I>M | A:158 | (30.50, 37.17, 10.11) |
| 7:106508487 | D>Y | A:161 | (35.41, 34.87, 4.13) | |
| 7:106508497 | D>G | A:164 | (39.94, 34.23, 2.82) | |
| 7:106508499 | COSM598228 | V>I | A:165 | (43.51, 31.78, 2.94) |
| 7:106508500 | V>A | A:165 | (43.51, 31.78, 2.94) | |
| 7:106508502 | S>C | A:166 | (44.75, 35.93, 1.49) | |
| 7:106508509 | V>G | A:168 | (47.41, 33.78, 6.19) | |
| 7:106508517 | rs549157001 COSM3631734 |
D>N | A:171 | (47.70, 26.72, 10.51) |
| 7:106508524 | rs569219747 | L>P | A:173 | (42.84, 31.44, 11.94) |
| 7:106508533 | T>M | A:176 | (41.15, 27.98, 15.94) | |
| 7:106508536 | COSM3394451 | R>H | A:177 | (37.37, 27.12, 11.25) |
| 7:106508553 | P>S | A:183 | (33.94, 23.45, 22.44) | |
| 7:106508554 | P>L | A:183 | (33.94, 23.45, 22.44) | |
| 7:106508557 | R>P | A:184 | (30.65, 24.21, 18.28) | |
| 7:106508563 | A>V | A:186 | (29.69, 20.39, 24.22) | |
| 7:106508566 | E>A | A:187 | (27.43, 24.12, 25.84) | |
| 7:106508574 | S>C | A:190 | (24.84, 20.53, 27.66) | |
| 7:106508576 | S>R | A:190 | (24.84, 20.53, 27.66) | |
| 7:106508577 | COSM744249 | R>G | A:191 | (21.74, 23.77, 24.53) |
| 7:106508583 | P>S | A:193 | (16.25, 22.19, 25.25) | |
| 7:106508584 | P>L | A:193 | (16.25, 22.19, 25.25) | |
| 7:106508587 | rs370215200 | K>R | A:194 | (12.36, 22.75, 27.54) |
| 7:106508590 | L>R | A:195 | (15.38, 26.48, 30.02) | |
| 7:106508595 | rs182921583 | A>T | A:197 | (14.01, 28.54, 24.34) |
| 7:106508596 | COSM3928722 | A>V | A:197 | (14.01, 28.54, 24.34) |
| 7:106508599 | M>T | A:198 | (11.85, 29.94, 27.46) | |
| 7:106508620 | K>R | A:205 | (21.95, 38.94, 42.99) | |
| 7:106508629 | P>L | A:208 | (17.33, 45.45, 46.50) | |
| 7:106508632 | E>V | A:209 | (17.23, 47.52, 51.43) | |
| 7:106508640 | rs533928881 | W>G | A:212 | (12.27, 43.33, 50.13) |
| 7:106508650 | I>T | A:215 | (6.99, 45.07, 48.46) | |
| 7:106508656 | N>I | A:217 | (2.83, 43.64, 51.13) | |
| 7:106508662 | C>Y | A:219 | (2.03, 41.10, 48.00) | |
| 7:106508673 | rs554272230 COSM1547858 |
V>I | A:223 | (-2.02, 41.11, 35.33) |
| 7:106508691 | T>A | A:229 | (-10.50, 38.09, 30.69) | |
| 7:106508713 | S>L | A:236 | (4.75, 35.35, 47.51) | |
| 7:106508720 | D>E | A:238 | (9.28, 33.17, 47.87) | |
| 7:106508721 | COSM289750 | D>N | A:239 | (5.72, 32.20, 44.76) |
| 7:106508742 | rs370717062 | Q>K | A:246 | (-0.58, 25.41, 41.43) |
| 7:106508746 | rs374827875 COSM3941935 |
S>N | A:247 | (-2.51, 29.24, 41.95) |
| 7:106508749 | rs375848575 | F>C | A:248 | (-4.58, 31.39, 37.09) |
| 7:106508805 | COSM3631736 | E>K | A:267 | (-4.68, 21.13, 30.51) |
| 7:106508832 | G>S | A:276 | (5.57, 42.53, 24.30) | |
| 7:106508844 | Y>N | A:280 | (9.37, 33.53, 27.78) | |
| 7:106508865 | rs542083249 | I>L | A:287 | (8.91, 35.92, 41.32) |
| 7:106508876 | COSM1083781 | F>L | A:290 | (12.27, 36.10, 37.36) |
| 7:106508890 | rs148558253 | H>R | A:295 | (12.01, 47.06, 34.92) |
| 7:106508891 | rs112943477 | H>Q | A:295 | (12.01, 47.06, 34.92) |
| 7:106508904 | COSM3631737 | G>R | A:300 | (6.36, 51.56, 39.15) |
| 7:106508905 | G>E | A:300 | (6.36, 51.56, 39.15) | |
| 7:106508919 | V>M | A:305 | (1.69, 37.97, 32.12) | |
| 7:106508922 | V>I | A:306 | (0.30, 36.58, 28.31) | |
| 7:106508923 | rs144045366 | V>E | A:306 | (0.30, 36.58, 28.31) |
| 7:106508931 | T>A | A:309 | (2.29, 28.03, 24.29) | |
| 7:106508952 | rs147267699 | D>H | A:316 | (16.35, 26.09, 18.86) |
| 7:106508955 | E>K | A:317 | (17.41, 22.15, 14.32) | |
| 7:106508970 | E>K | A:322 | (32.54, 18.83, 10.28) | |
| 7:106509078 | rs62001903 | D>Y | A:358 | (71.41, 25.75, 24.61) |
| 7:106509081 | rs187257485 | R>C | A:359 | (72.03, 29.01, 18.61) |
| 7:106509089 | F>L | A:361 | (66.47, 34.38, 18.33) | |
| 7:106509090 | rs374506356 | R>G | A:362 | (70.35, 33.71, 14.15) |
| 7:106509091 | COSM744245 | R>K | A:362 | (70.35, 33.71, 14.15) |
| 7:106509097 | COSM213227 COSM1699151 |
K>R | A:364 | (68.44, 36.94, 7.98) |
| 7:106509112 | D>G | A:369 | (59.55, 46.55, -0.57) | |
| 7:106509130 | COSM3631739 | R>Q | A:375 | (56.68, 62.43, 2.12) |
| 7:106509135 | T>A | A:377 | (61.98, 65.00, 4.57) | |
| 7:106509138 | COSM1083789 | D>N | A:378 | (64.84, 62.85, 2.27) |
| 7:106509139 | rs569081649 | D>A | A:378 | (64.84, 62.85, 2.27) |
| 7:106509154 | V>A | A:383 | (64.67, 47.58, 11.65) | |
| 7:106509167 | I>M | A:387 | (62.03, 39.43, 22.06) | |
| 7:106509171 | H>Y | A:389 | (55.80, 37.47, 27.51) | |
| 7:106509174 | COSM1547856 | G>R | A:390 | (53.58, 41.36, 27.99) |
| 7:106509224 | E>D | A:406 | (61.32, 52.19, -3.33) | |
| 7:106509240 | rs148196703 | V>M | A:412 | (71.28, 41.43, 8.87) |
| 7:106509259 | I>T | A:418 | (67.31, 35.36, 24.70) | |
| 7:106509265 | I>T | A:420 | (66.00, 29.05, 21.52) | |
| 7:106509291 | L>V | A:429 | (59.35, 39.17, 16.35) | |
| 7:106509302 | rs541565025 | Q>H | A:432 | (58.88, 48.66, 15.52) |
| 7:106509303 | I>V | A:433 | (60.00, 50.80, 10.61) | |
| 7:106509307 | Y>F | A:434 | (61.59, 53.37, 14.86) | |
| 7:106509391 | rs201887530 | Y>C | A:462 | (55.50, 51.61, 8.64) |
| 7:106509394 | Y>C | A:463 | (52.56, 48.03, 13.83) | |
| 7:106509412 | rs368931206 | I>T | A:469 | (56.27, 29.50, 20.28) |
| 7:106509429 | L>V | A:475 | (60.54, 27.39, 16.79) | |
| 7:106509433 | R>H | A:476 | (57.22, 30.47, 13.68) | |
| 7:106509436 | rs200175951 COSM1083796 |
R>H | A:477 | (62.23, 26.83, 9.97) |
| 7:106509438 | G>R | A:478 | (61.53, 30.32, 7.58) | |
| 7:106509522 | rs201694007 | T>A | A:506 | (49.07, 40.52, 8.56) |
| 7:106509533 | rs140765012 | D>E | A:509 | (46.79, 46.54, 1.72) |
| 7:106509537 | COSM25369 COSM1447107 |
E>K | A:511 | (48.24, 47.38, -3.82) |
| 7:106509546 | rs199845412 | M>V | A:514 | (55.95, 48.35, 4.48) |
| 7:106509558 | I>V | A:518 | (62.24, 37.70, 7.82) | |
| 7:106509579 | COSM1447109 | H>Y | A:525 | (61.13, 19.69, 20.46) |
| 7:106509647 | M>I | A:547 | (58.64, 36.76, 55.95) | |
| 7:106509652 | N>S | A:549 | (57.58, 41.54, 60.86) | |
| 7:106509657 | L>F | A:551 | (60.43, 41.74, 54.88) | |
| 7:106509660 | R>C | A:552 | (54.98, 39.11, 56.48) | |
| 7:106509665 | K>N | A:553 | (55.08, 44.89, 57.99) | |
| 7:106509667 | rs376883235 | Q>R | A:554 | (58.52, 45.64, 53.21) |
| 7:106509676 | rs139426517 | A>V | A:557 | (52.47, 47.33, 51.08) |
| 7:106509679 | I>S | A:558 | (53.89, 45.79, 47.62) | |
| 7:106509694 | COSM48674 | P>L | A:563 | (46.17, 48.44, 40.06) |
| 7:106509696 | L>F | A:564 | (48.13, 51.95, 37.64) | |
| 7:106509718 | D>V | A:571 | (59.06, 45.74, 44.78) | |
| 7:106509725 | E>D | A:573 | (64.09, 40.91, 43.98) | |
| 7:106509747 | COSM3922433 | E>K | A:581 | (53.49, 34.26, 51.98) |
| 7:106509768 | rs146487441 | A>T | A:588 | (49.15, 39.55, 44.57) |
| 7:106509796 | K>T | A:597 | (62.54, 36.82, 35.26) | |
| 7:106509819 | A>T | A:605 | (58.91, 26.24, 35.80) | |
| 7:106509856 | W>S | A:617 | (42.99, 32.14, 42.32) | |
| 7:106509871 | L>W | A:622 | (35.05, 35.96, 41.89) | |
| 7:106509873 | rs375751703 | D>N | A:623 | (37.91, 40.02, 42.38) |
| 7:106509933 | rs28763989 | I>V | A:643 | (43.89, 31.23, 36.80) |
| 7:106509943 | rs185704316 | Q>P | A:646 | (39.45, 29.20, 37.41) |
| 7:106509969 | rs145539077 | D>N | A:655 | (27.29, 39.15, 36.56) |
| 7:106509972 | V>I | A:656 | (28.40, 37.50, 31.90) | |
| 7:106509978 | H>Y | A:658 | (26.66, 43.23, 34.26) | |
| 7:106509987 | rs370801896 | L>I | A:661 | (31.87, 44.76, 25.93) |
| 7:106513001 | Y>C | A:672 | (48.66, 31.71, 21.11) | |
| 7:106513012 | A>T | A:676 | (40.32, 29.96, 27.39) | |
| 7:106513018 | rs187473519 | A>T | A:678 | (37.52, 32.38, 23.84) |
| 7:106513031 | L>Q | A:682 | (31.88, 29.82, 22.57) | |
| 7:106513037 | R>H | A:684 | (28.49, 31.55, 29.80) | |
| 7:106513040 | G>V | A:685 | (26.43, 32.10, 24.40) | |
| 7:106513165 | COSM200491 | R>I | A:690 | (20.14, 39.14, 26.88) |
| 7:106513168 | COSM1083810 | I>T | A:691 | (24.96, 35.90, 26.60) |
| 7:106513171 | G>D | A:692 | (24.48, 35.63, 22.34) | |
| 7:106513232 | R>S | A:712 | (41.66, 36.41, 17.24) | |
| 7:106513255 | rs199590448 | Y>C | A:720 | (27.05, 31.83, 18.72) |
| 7:106513264 | rs201158285 | G>A | A:723 | (25.11, 26.59, 17.95) |
| 7:106513275 | A>P | A:727 | (16.12, 30.72, 15.43) | |
| 7:106513280 | M>I | A:728 | (19.15, 33.09, 17.23) | |
| 7:106513287 | COSM3254617 | D>N | A:731 | (16.42, 36.52, 14.67) |
| 7:106513297 | Q>L | A:734 | (15.42, 39.54, 9.55) | |
| 7:106513302 | V>I | A:736 | (21.79, 41.97, 9.25) | |
| 7:106513314 | rs559655430 COSM94998 |
E>K | A:740 | (22.61, 45.91, 5.43) |
| 7:106513317 | M>V | A:741 | (18.38, 47.78, 4.34) | |
| 7:106513319 | M>I | A:741 | (18.38, 47.78, 4.34) | |
| 7:106513323 | rs371499467 | Q>E | A:743 | (24.02, 51.50, 8.10) |
| 7:106513342 | I>T | A:749 | (20.74, 61.49, 3.80) | |
| 7:106513345 | K>R | A:750 | (26.14, 62.52, 6.14) | |
| 7:106513348 | rs528601604 COSM1699153 |
S>L | A:751 | (26.33, 62.86, 1.11) |
| 7:106513371 | COSM598222 | V>I | A:759 | (16.61, 70.46, 7.40) |
| 7:106515177 | rs182430488 | L>M | A:774 | (12.94, 50.13, 2.48) |
| 7:106515184 | rs144096589 | N>S | A:776 | (6.54, 48.12, 0.55) |
| 7:106515190 | Q>R | A:778 | (13.43, 43.67, 0.55) | |
| 7:106515198 | rs146675267 | E>K | A:781 | (7.09, 41.39, 7.96) |
| 7:106515202 | S>N | A:782 | (9.93, 41.40, 12.01) | |
| 7:106515207 | R>G | A:784 | (14.56, 40.11, 18.27) | |
| 7:106515222 | P>A | A:789 | (16.71, 41.36, 22.73) | |
| 7:106515226 | rs139231934 | G>V | A:790 | (12.80, 41.27, 23.53) |
| 7:106515241 | rs143259740 | A>V | A:795 | (6.64, 48.40, 10.96) |
| 7:106515247 | A>V | A:797 | (6.39, 54.89, 11.12) | |
| 7:106519982 | M>V | A:804 | (18.59, 64.21, 13.64) | |
| 7:106520000 | COSM3877005 | P>T | A:810 | (21.40, 61.59, 12.09) |
| 7:106520027 | rs370034420 COSM1220605 |
D>N | A:819 | (3.58, 41.79, 20.38) |
| 7:106520033 | T>A | A:821 | (0.16, 41.17, 23.09) | |
| 7:106520037 | A>V | A:822 | (1.40, 44.90, 23.37) | |
| 7:106520045 | N>D | A:825 | (-0.44, 52.47, 22.13) | |
| 7:106520058 | G>E | A:829 | (12.96, 54.27, 18.78) | |
| 7:106520061 | I>S | A:830 | (15.96, 53.34, 16.52) | |
| 7:106520063 | I>L | A:831 | (18.99, 57.29, 16.56) | |
| 7:106520068 | F>L | A:832 | (20.33, 53.98, 12.34) | |
| 7:106520087 | COSM85064 | R>C | A:839 | (34.83, 51.23, 19.66) |
| 7:106522569 | COSM200492 | R>Q | A:849 | (24.80, 49.37, 31.39) |
| 7:106522576 | M>I | A:851 | (28.89, 52.56, 38.08) | |
| 7:106522592 | rs28763991 | T>A | A:857 | (25.46, 45.78, 46.02) |
| 7:106522611 | C>Y | A:863 | (18.13, 56.84, 38.47) | |
| 7:106522637 | T>A | A:872 | (27.60, 48.46, 13.38) | |
| 7:106522647 | K>R | A:875 | (32.90, 56.37, 12.65) | |
| 7:106522648 | rs561495434 COSM1447113 |
K>N | A:875 | (32.90, 56.37, 12.65) |
| 7:106523482 | M>I | A:878 | (22.12, 51.23, 16.72) | |
| 7:106523486 | COSM1083818 | E>K | A:880 | (17.39, 53.58, 23.32) |
| 7:106523490 | rs144246024 | I>T | A:881 | (14.85, 56.98, 21.19) |
| 7:106523493 | V>A | A:882 | (14.80, 58.12, 25.75) | |
| 7:106523501 | rs373006568 COSM3254622 |
A>T | A:885 | (13.34, 63.45, 26.16) |
| 7:106523519 | rs573193881 | I>V | A:891 | (14.65, 73.13, 28.59) |
| 7:106523541 | rs535355652 | N>S | A:898 | (18.49, 81.49, 18.59) |
| 7:106523575 | H>Q | A:909 | (9.21, 77.25, 35.24) | |
| 7:106524607 | A>V | A:923 | (8.36, 62.65, 41.74) | |
| 7:106524663 | L>I | A:942 | (34.59, 57.96, 33.65) | |
| 7:106524669 | I>V | A:944 | (33.02, 62.16, 31.00) | |
| 7:106524699 | I>V | A:954 | (15.19, 65.66, 31.34) | |
| 7:106526684 | F>L | A:993 | (15.21, 76.85, 41.51) | |
| 7:106526685 | F>C | A:993 | (15.21, 76.85, 41.51) | |
| 7:106526687 | V>L | A:994 | (14.91, 71.87, 40.99) | |
| 7:106526694 | G>E | A:996 | (15.87, 74.59, 46.44) | |
| 7:106526703 | COSM3631754 | G>E | A:999 | (22.69, 79.96, 45.60) |
| 7:106526714 | rs139918549 | S>G | A:1003 | (17.74, 72.52, 50.80) |
| 7:106545563 | rs201355541 | V>I | A:1014 | (28.88, 60.86, 49.58) |
| 7:106545568 | K>N | A:1015 | (26.30, 57.90, 50.88) | |
| 7:106545569 | A>P | A:1016 | (27.68, 56.90, 45.77) | |
| 7:106545576 | L>P | A:1018 | (32.01, 56.23, 49.47) | |
| 7:106545584 | rs142182764 | R>S | A:1021 | (36.46, 55.09, 47.41) |
| 7:106545585 | rs376453517 COSM1447114 |
R>H | A:1021 | (36.46, 55.09, 47.41) |
| 7:106545608 | I>V | A:1029 | (41.04, 47.17, 34.98) | |
| 7:106545614 | F>L | A:1031 | (39.74, 54.03, 32.50) | |
| 7:106545636 | G>E | A:1038 | (38.85, 51.97, 22.54) | |
| 7:106545654 | S>N | A:1044 | (49.86, 53.50, 29.04) | |
| 7:106545670 | rs151166020 | E>D | A:1049 | (46.99, 58.23, 36.63) |
| 7:106545703 | N>K | A:1060 | (39.99, 58.67, 54.75) | |
| 7:106545716 | rs151301577 | K>E | A:1065 | (32.23, 63.12, 52.90) |
[+] COSMIC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 7:106508470 | COSM3431069 | T>M | A:155 | (30.00, 35.39, 5.42) |
| 7:106508473 | COSM1579094 | A>V | A:156 | (26.58, 37.70, 5.86) |
| 7:106508490 | COSM217395 | V>I | A:162 | (36.46, 32.58, 7.68) |
| 7:106508499 | COSM598228 | V>I | A:165 | (43.51, 31.78, 2.94) |
| 7:106508557 | COSM3254565 | R>H | A:184 | (30.65, 24.21, 18.28) |
| 7:106508581 | COSM3877001 | D>G | A:192 | (17.48, 22.48, 28.66) |
| 7:106508673 | COSM1547858 | V>I | A:223 | (-2.02, 41.11, 35.33) |
| 7:106508805 | COSM3631736 | E>K | A:267 | (-4.68, 21.13, 30.51) |
| 7:106508824 | COSM1673431 | R>H | A:273 | (4.58, 36.65, 26.89) |
| 7:106508826 | COSM200486 | V>I | A:274 | (6.54, 39.76, 29.06) |
| 7:106508850 | COSM1547857 | V>L | A:282 | (10.26, 30.30, 33.28) |
| 7:106508856 | COSM3718684 | E>K | A:284 | (12.08, 26.27, 39.60) |
| 7:106508867 | COSM1755008 | I>M | A:287 | (8.91, 35.92, 41.32) |
| 7:106508904 | COSM3631737 | G>R | A:300 | (6.36, 51.56, 39.15) |
| 7:106508955 | COSM4562931 | E>K | A:317 | (17.41, 22.15, 14.32) |
| 7:106509138 | COSM1083789 | D>N | A:378 | (64.84, 62.85, 2.27) |
| 7:106509141 | COSM75935 | L>I | A:379 | (64.74, 60.63, 6.54) |
| 7:106509174 | COSM1547856 | G>W | A:390 | (53.58, 41.36, 27.99) |
| 7:106509283 | COSM25368 | G>E | A:426 | (53.82, 33.91, 23.51) |
| 7:106509402 | COSM1673432 | L>M | A:466 | (55.98, 36.52, 14.13) |
| 7:106509436 | COSM1083796 | R>H | A:477 | (62.23, 26.83, 9.97) |
| 7:106509537 | COSM25369 | E>K | A:511 | (48.24, 47.38, -3.82) |
| 7:106509582 | COSM125374 | P>S | A:526 | (60.39, 23.99, 22.55) |
| 7:106509589 | COSM3254599 | A>V | A:528 | (55.80, 21.78, 28.80) |
| 7:106509637 | COSM3831564 | R>P | A:544 | (60.46, 24.06, 53.75) |
| 7:106509723 | COSM3631744 | E>K | A:573 | (64.09, 40.91, 43.98) |
| 7:106513165 | COSM200491 | R>I | A:690 | (20.14, 39.14, 26.88) |
| 7:106513287 | COSM3254617 | D>N | A:731 | (16.42, 36.52, 14.67) |
| 7:106513371 | COSM598222 | V>I | A:759 | (16.61, 70.46, 7.40) |
| 7:106515198 | COSM1083814 | E>K | A:781 | (7.09, 41.39, 7.96) |
| 7:106520100 | COSM125375 | L>H | A:843 | (32.90, 50.73, 26.22) |
| 7:106522592 | COSM3762311 | T>A | A:857 | (25.46, 45.78, 46.02) |
| 7:106523501 | COSM3254622 | A>T | A:885 | (13.34, 63.45, 26.16) |
| 7:106524646 | COSM42951 | C>S | A:936 | (27.49, 63.82, 39.06) |
| 7:106526603 | COSM48675 | G>W | A:966 | (33.05, 60.20, 22.31) |
| 7:106526718 | COSM43063 | P>L | A:1004 | (15.53, 70.02, 52.04) |
| 7:106545584 | COSM125376 | R>S | A:1021 | (36.46, 55.09, 47.41) |