General Structure Information
| PDB ID | 3s95 |
| HGNC Gene Label(s) | LIMK1 |
| Structure Name | crystal structure of the human limk1 kinase domain in complex with staurosporine |
| Resolution | 1.65Å |
| Reference | AUTH A.BELTRAMI,A.CHAIKUAD,N.DAGA,J.M.ELKINS,P.MAHAJAN,AUTH 2 P.SAVITSKY,M.VOLLMAR,T.KROJER,J.R.C.MUNIZ,O.FEDOROV,AUTH 3 C.K.ALLERSTON,W.W.YUE,O.GILEADI,F.VON DELFT,C.H.ARROWSMITH,AUTH 4 A.M.EDWARDS,J.WEIGELT,C.BOUNTRA,S.KNAPP,A.BULLOCKTITL CRYSTAL STRUCTURE OF THE HUMAN LIMK1 KINASE DOMAIN INTITL 2 COMPLEX WITH STAUROSPORINEREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 288 |
| Number Of SNVs | 51 |
| Number Of Permutations | 28984 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.033 |
| p-value | 0.079 |
COSMIC
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 51 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.073 |
| p-value | 0.73 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
