General Structure Information
| PDB ID | 4nw5 |
| HGNC Gene Label(s) | RPS6KA3 |
| Structure Name | rsk2 n-terminal kinase in complex with 2-amino-7-substituted benzoxazole compound 8 |
| Resolution | 1.94Å |
| Reference | AUTH A.COSTALES,M.MATHUR,S.RAMURTHY,J.LAN,S.SUBRAMANIAN,R.JAIN,AUTH 2 G.ATALLAH,L.SETTI,M.LINDVALL,B.A.APPLETON,E.ORNELAS,AUTH 3 P.FEUCHT,B.WARNE,L.DOYLE,S.E.BASHAM,I.ARONCHIK,AUTH 4 A.B.JEFFERSON,C.M.SHAFERTITL 2-AMINO-7-SUBSTITUTED BENZOXAZOLE ANALOGS AS POTENT RSK2TITL 2 INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 24 1592 2014REFN ISSN 0960-894XPMID 24534486DOI 10.1016/J.BMCL.2014.01.058 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 302 |
| Number Of SNVs | 7 |
| Number Of Permutations | 5427 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | 0.238 |
| p-value | 0.048 |
ClinVar
| Number Of Residues | 302 |
| Number Of SNVs | 7 |
| Number Of Permutations | 5378 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.476 |
| p-value | 0.074 |
COSMIC
| Number Of Residues | 302 |
| Number Of SNVs | 7 |
| Number Of Permutations | 1517 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.286 |
| p-value | 0.375 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 7 |
| Number Of ClinVar SNVs | 7 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.476 |
| p-value | 0.029 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 7 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.274 |
| p-value | 0.056 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
