Assessment of Structural Intolerance and Durability
General Structure Information 2o0l SRM human spermidine synthase 1.99Å AUTH H.WU,J.MIN,Y.IKEGUCHI,H.ZENG,A.DONG,P.LOPPNAU,A.E.PEGG,AUTH 2 A.N.PLOTNIKOVTITL STRUCTURE AND MECHANISM OF SPERMIDINE SYNTHASES.REF BIOCHEMISTRY V. 46 8331 2007REFN ISSN 0006-2960PMID 17585781DOI 10.1021/BI602498K Variant Set Distributions Mapped Variants
General Structure Information 3ii0 GOT1 crystal structure of human glutamate oxaloacetate transaminase 1 (got1) 2.05Å AUTH E.UGOCHUKWU,E.PILKA,C.COOPER,J.E.BRAY,W.W.YUE,J.MUNIZ,AUTH 2 A.CHAIKUAD,K.L.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN GLUTAMATE OXALOACETATETITL 2 TRANSAMINASE 1 (GOT1)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4eeg B4GALT1 crystal structure of human m340h-beta-1,4-galactosyltransferase-1 (m340h-b4gal-t1) in complex with glcnac-beta1,6-gal-beta 2.2Å AUTH B.RAMAKRISHNAN,E.BOEGGEMAN,P.K.QASBATITL BINDING OF N-ACETYLGLUCOSAMINE (GLCNAC) BETA 1-6-BRANCHEDTITL 2 OLIGOSACCHARIDE ACCEPTORS TO BETA 4-GALACTOSYLTRANSFERASE ITITL 3 REVEALS A NEW LIGAND BINDING MODE.REF J.BIOL.CHEM. V. 287 28666 2012REFN ISSN 0021-9258PMID 22740701DOI 10.1074/JBC.M112.373514 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1ksw SRC structure of human c-src tyrosine kinase (thr338gly mutant) in complex with n6-benzyl adp 2.8Å AUTH L.A.WITUCKI,X.HUANG,K.SHAH,Y.LIU,S.KYIN,M.J.ECK,AUTH 2 K.M.SHOKATTITL MUTANT TYROSINE KINASES WITH UNNATURAL NUCLEOTIDETITL 2 SPECIFICITY RETAIN THE STRUCTURE ANDTITL 3 PHOSPHO-ACCEPTOR SPECIFICITY OF THE WILD-TYPETITL 4 ENZYME.REF CHEM.BIOL. V. 9 25 2002REFN ISSN 1074-5521PMID 11841936DOI 10.1016/S1074-5521(02)00091-1 Variant Set Distributions […]
General Structure Information 3e3b CSNK2A2 crystal structure of catalytic subunit of human protein kinase ck2alpha prime with a potent indazole-derivative inhibitor 3.2Å AUTH T.NAKANIWA,T.KINOSHITA,Y.SEKIGUCHI,T.TADA,AUTH 2 I.NAKANISHI,K.KITAURA,Y.SUZUKI,H.OHNO,A.HIRASAWA,AUTH 3 G.TSUJIMOTOTITL STRUCTURE OF HUMAN PROTEIN KINASE CK2ALPHA2 WITH ATITL 2 POTENT INDAZOLE-DERIVATIVE INHIBITORREF ACTA CRYSTALLOGR.,SECT.F V. 65 75 2009REFN ESSN 1744-3091PMID 19193990DOI 10.1107/S1744309108043194 Variant Set Distributions Ripley’s K […]
General Structure Information 2j0f TYMP structural basis for non-competitive product inhibition in human thymidine phosphorylase: implication for drug design 2.31Å AUTH K.EL OMARI,A.BRONCKAERS,S.LIEKENS,M.PEREZ-PEREZ,AUTH 2 J.BALZARINI,D.K.STAMMERSTITL STRUCTURAL BASIS FOR NON-COMPETITIVE PRODUCTTITL 2 INHIBITION IN HUMAN THYMIDINE PHOSPHORYLASE:TITL 3 IMPLICATIONS FOR DRUG DESIGN.REF BIOCHEM.J. V. 399 199 2006REFN ISSN 0264-6021PMID 16803458DOI 10.1042/BJ20060513 Variant Set Distributions Ripley’s K […]
General Structure Information 3g33 CDK4 crystal structure of cdk4/cyclin d3 3.0Å AUTH T.TAKAKI,A.ECHALIER,N.R.BROWN,T.HUNT,J.A.ENDICOTT,M.E.NOBLETITL THE STRUCTURE OF CDK4/CYCLIN D3 HAS IMPLICATIONS FOR MODELSTITL 2 OF CDK ACTIVATION.REF PROC.NATL.ACAD.SCI.USA V. 106 4171 2009REFN ISSN 0027-8424PMID 19237555DOI 10.1073/PNAS.0809674106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2cci CCNA2 crystal structure of phospho-cdk2 cyclin a in complex with a peptide containing both the substrate and recruitment sites of cdc6 2.7Å AUTH K.Y.CHENG,M.E.M.NOBLE,V.SKAMNAKI,N.R.BROWN,E.D.LOWE,AUTH 2 L.KONTOGIANNIS,K.SHEN,P.A.COLE,G.SILIGARDI,L.N.JOHNSONTITL THE ROLE OF THE PHOSPHO-CDK2/CYCLIN A RECRUITMENT SITE INTITL 2 SUBSTRATE RECOGNITIONREF J.BIOL.CHEM. V. 281 23167 2006REFN ISSN 0021-9258PMID 16707497DOI 10.1074/JBC.M600480200 Variant Set Distributions Mapped […]
General Structure Information 3hng FLT1 crystal structure of vegfr1 in complex with n-(4-chlorophenyl)-2- ((pyridin-4-ylmethyl)amino)benzamide 2.7Å AUTH L.TRESAUGUES,A.ROOS,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTENYOVA,M.MOCHE,T.NYMAN,C.PERSSON,T.KRAGH-NIELSEN,AUTH 5 A.KOTZCH,J.SAGEMARK,H.SCHUELER,P.SCHUTZ,M.I.SIPONEN,AUTH 6 L.SVENSSON,A.G.THORSELL,S.VAN DER BERG,J.WEIGELT,M.WELIN,AUTH 7 M.WISNIEWSKA,P.NORDLUNDTITL CRYSTAL STRUCTURE OF VEGFR1 IN COMPLEX WITHTITL 2 N-(4-CHLOROPHENYL)-2-((PYRIDIN-4-YLMETHYL)AMINO)BENZAMIDEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3n46 FDPS human fpps complex with nov_980 and zoledronic acid/mg2+ 2.35Å AUTH W.JAHNKE,J.M.RONDEAU,S.COTESTA,A.MARZINZIK,X.PELLE,M.GEISER,AUTH 2 A.STRAUSS,M.GOTTE,F.BITSCH,R.HEMMIG,C.HENRY,S.LEHMANN,AUTH 3 J.F.GLICKMAN,T.P.RODDY,S.J.STOUT,J.R.GREENTITL ALLOSTERIC NON-BISPHOSPHONATE FPPS INHIBITORS IDENTIFIED BYTITL 2 FRAGMENT-BASED DISCOVERY.REF NAT.CHEM.BIOL. V. 6 660 2010REFN ISSN 1552-4450PMID 20711197DOI 10.1038/NCHEMBIO.421 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants