General Structure Information
| PDB ID | 2j0f |
| HGNC Gene Label(s) | TYMP |
| Structure Name | structural basis for non-competitive product inhibition in human thymidine phosphorylase: implication for drug design |
| Resolution | 2.31Å |
| Reference | AUTH K.EL OMARI,A.BRONCKAERS,S.LIEKENS,M.PEREZ-PEREZ,AUTH 2 J.BALZARINI,D.K.STAMMERSTITL STRUCTURAL BASIS FOR NON-COMPETITIVE PRODUCTTITL 2 INHIBITION IN HUMAN THYMIDINE PHOSPHORYLASE:TITL 3 IMPLICATIONS FOR DRUG DESIGN.REF BIOCHEM.J. V. 399 199 2006REFN ISSN 0264-6021PMID 16803458DOI 10.1042/BJ20060513 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 446 |
| Number Of SNVs | 109 |
| Number Of Permutations | 49946 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.053 |
| p-value | 0.136 |
ClinVar
| Number Of Residues | 446 |
| Number Of SNVs | 13 |
| Number Of Permutations | 6486 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.41 |
| p-value | 0.014 |
COSMIC
| Number Of Residues | 446 |
| Number Of SNVs | 8 |
| Number Of Permutations | 6542 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.107 |
| p-value | 0.856 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 109 |
| Number Of ClinVar SNVs | 13 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.22 |
| p-value | 0.018 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 109 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 32.0 |
| K Statistic | -0.176 |
| p-value | 0.598 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
