Assessment of Structural Intolerance and Durability
General Structure Information 1uf0 DCLK1 solution structure of the n-terminal dcx domain of human doublecortin-like kinase -1.0Å AUTH K.SAITO,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE N-TERMINAL DCX DOMAIN OFTITL 2 HUMAN DOUBLECORTIN-LIKE KINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ydj CHEK1 discovery of checkpoint kinase inhibitor azd7762 by structure based design and optimization of thiophene carboxamide ureas 1.85Å AUTH V.OZA,S.ASHWELL,L.ALMEIDA,P.BRASSIL,J.BREED,C.DENG,T.GERO,AUTH 2 M.GRONDINE,C.HORN,S.IOANNIDIS,D.LIU,P.LYNE,N.NEWCOMBE,AUTH 3 M.PASS,J.A.READ,S.READY,S.ROWSELL,M.SU,D.TOADER,M.VASBINDER,AUTH 4 D.YU,Y.YU,Y.XUE,S.ZABLUDOFF,J.JANETKATITL DISCOVERY OF CHECKPOINT KINASE INHIBITOR (S)-5-(3-TITL 2 FLUOROPHENYL)-N-(PIPERIDIN-3-YL)-3-UREIDOTHIOPHENE-2-TITL 3 CARBOXAMIDE (AZD7762) BY STRUCTURE-BASED DESIGN ANDTITL 4 OPTIMIZATION OF THIOPHENECARBOXAMIDE UREAS.REF J.MED.CHEM. V. 55 5130 2012REFN […]
General Structure Information 1ehw NME4 human nucleoside diphosphate kinase 4 2.4Å AUTH L.MILON,P.MEYER,M.CHIADMI,A.MUNIER,M.JOHANSSON,A.KARLSSON,AUTH 2 I.LASCU,J.CAPEAU,J.JANIN,M.L.LACOMBETITL THE HUMAN NM23-H4 GENE PRODUCT IS A MITOCHONDRIAL NUCLEOSIDETITL 2 DIPHOSPHATE KINASE.REF J.BIOL.CHEM. V. 275 14264 2000REFN ISSN 0021-9258PMID 10799505DOI 10.1074/JBC.275.19.14264 Variant Set Distributions Mapped Variants
General Structure Information 2xs6 PIK3R2 crystal structure of the rhogap domain of human pik3r2 2.09Å AUTH L.TRESAUGUES,M.WELIN,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,S.KOL,T.KOTENYOVA,AUTH 4 E.KOUZNETSOVA,M.MOCHE,T.NYMAN,C.PERSSON,H.SCHULER,P.SCHUTZ,AUTH 5 M.I.SIPONEN,A.G.THORSELL,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,P.NORDLUNDTITL CRYSTAL STRUCTURE OF THE RHO-GAP DOMAIN OF HUMAN PIK3R2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants