Assessment of Structural Intolerance and Durability
General Structure Information 4f9a CDC7 human cdc7 kinase in complex with dbf4 and nucleotide 2.17Å AUTH S.HUGHES,F.ELUSTONDO,A.DI FONZO,F.G.LEROUX,A.C.WONG,AUTH 2 A.P.SNIJDERS,S.J.MATTHEWS,P.CHEREPANOVTITL CRYSTAL STRUCTURE OF HUMAN CDC7 KINASE IN COMPLEX WITH ITSTITL 2 ACTIVATOR DBF4.REF NAT.STRUCT.MOL.BIOL. V. 19 1101 2012REFN ISSN 1545-9993PMID 23064647DOI 10.1038/NSMB.2404 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4c59 GAK structure of gak kinase in complex with nanobody (nbgak_4) 2.8Å AUTH A.CHAIKUAD,T.KEATES,C.VINCKE,M.KAUFHOLZ,M.ZENN,B.ZIMMERMANN,AUTH 2 C.GUTIERREZ,R.ZHANG,C.HATZOS-SKINTGES,A.JOACHIMIAK,AUTH 3 S.MUYLDERMANS,F.W.HERBERG,S.KNAPP,S.MULLERTITL STRUCTURE OF CYCLIN G-ASSOCIATED KINASE (GAK) TRAPPED INTITL 2 DIFFERENT CONFORMATIONS USING NANOBODIES.REF BIOCHEM.J. V. 459 59 2014REFN ISSN 0264-6021PMID 24438162DOI 10.1042/BJ20131399 Variant Set Distributions Mapped Variants
General Structure Information 2dyl MAP2K7 crystal structure of human mitogen-activated protein kinase kinase 7 activated mutant (s287d, t291d) 2.45Å AUTH M.KUKIMOTO-NIINO,T.TAKAGI,T.KAMINISHI,AUTH 2 T.UCHIKUBO-KAMO,T.TERADA,O.MATSUZAKI,M.SHIROUZU,AUTH 3 S.YOKOYAMATITL CRYSTAL STRUCTURE OF HUMAN MITOGEN-ACTIVATEDTITL 2 PROTEIN KINASE KINASE 7 ACTIVATED MUTANT (S287D,TITL 3 T291D)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2p0w HAT1 human histone acetyltransferase 1 (hat1) 1.9Å AUTH H.WU,J.MIN,H.ZENG,P.LOPPNAU,J.WEIGELT,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF HUMAN HISTONE ACETYLTRANSFERASE 1TITL 2 (HAT1) IN COMPLEX WITH ACETYLCOENZYME A AND HISTONE PEPTIDETITL 3 H4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ar5 PIK3C2A crystal structure of the mammalian c2alpha-pi3 kinase px-domain 1.8Å AUTH G.N.PARKINSON,D.VINES,P.C.DRISCOLL,S.DJORDJEVICTITL LIGAND-BINDING SPECIFICITY OF PI3KINASE C2ALPHA PX DOMAIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2xik STK25 structure of human ysk1 (yeast sps1-ste20-related kinase 1) 1.97Å AUTH J.R.C.MUNIZ,P.RELLOS,M.VOLLMAR,C.ALLERSTON,A.CHAIKUAD,AUTH 2 P.SAVITSKY,G.BERRIDGE,B.BRENNER,J.M.ELKINS,N.DAGA,O.GILEADI,AUTH 3 P.MAHAJAN,B.SHRESTHA,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 4 J.WEIGELT,C.BOUNTRA,S.KNAPPTITL STRUCTURE OF HUMAN YSK1 (YEAST SPS1-STE20-RELATED KINASE 1)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ekp BCAT2 crystal structure of human branched chain amino acid aminotransferase (mitochondrial) complexed with pyridoxal-5-phosphate at 2.5 angstroms (monoclinic form). 2.5Å AUTH N.YENNAWAR,J.DUNBAR,M.CONWAY,S.HUTSON,G.FARBERTITL THE STRUCTURE OF HUMAN MITOCHONDRIAL BRANCHED-CHAINTITL 2 AMINOTRANSFERASE.REF ACTA CRYSTALLOGR.,SECT.D V. 57 506 2001REFN ISSN 0907-4449PMID 11264579DOI 10.1107/S0907444901001925 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3cok PLK4 crystal structure of plk4 kinase 2.25Å AUTH S.ATWELL,S.K.BURLEY,A.HOULE,B.LEON,L.A.PELLETIER,AUTH 2 J.M.SAUDERTITL CRYSTAL STRUCTURE OF PLK4 KINASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4boc POLRMT structure of mitochondrial rna polymerase elongation complex 2.65Å AUTH K.SCHWINGHAMMER,A.C.M.CHEUNG,Y.I.MOROZOV,K.AGARONYAN,AUTH 2 D.TEMIAKOV,P.CRAMERTITL STRUCTURE OF HUMAN MITOCHONDRIAL RNA POLYMERASE ELONGATIONTITL 2 COMPLEXREF NAT.STRUCT.MOL.BIOL. V. 20 1298 2013REFN ISSN 1545-9993PMID 24096365DOI 10.1038/NSMB.2683 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2r5t SGK1 crystal structure of inactive serum and glucocorticoid- regulated kinase 1 in complex with amp-pnp 1.9Å AUTH B.ZHAO,R.LEHR,A.M.SMALLWOOD,T.F.HO,K.MALEY,AUTH 2 T.RANDALL,M.S.HEAD,K.K.KORETKE,C.G.SCHNACKENBERGTITL CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF SERUMTITL 2 AND GLUCOCORTICOID-REGULATED KINASE 1 IN COMPLEXTITL 3 WITH AMP PNP.REF PROTEIN SCI. V. 16 2761 2007REFN ISSN 0961-8368PMID 17965184DOI 10.1110/PS.073161707 Variant Set […]