General Structure Information
| PDB ID | 2dyl |
| HGNC Gene Label(s) | MAP2K7 |
| Structure Name | crystal structure of human mitogen-activated protein kinase kinase 7 activated mutant (s287d, t291d) |
| Resolution | 2.45Å |
| Reference | AUTH M.KUKIMOTO-NIINO,T.TAKAGI,T.KAMINISHI,AUTH 2 T.UCHIKUBO-KAMO,T.TERADA,O.MATSUZAKI,M.SHIROUZU,AUTH 3 S.YOKOYAMATITL CRYSTAL STRUCTURE OF HUMAN MITOGEN-ACTIVATEDTITL 2 PROTEIN KINASE KINASE 7 ACTIVATED MUTANT (S287D,TITL 3 T291D)REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 272 |
| Number Of SNVs | 47 |
| Number Of Permutations | 23834 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.087 |
| p-value | 0.595 |
COSMIC
| Number Of Residues | 272 |
| Number Of SNVs | 10 |
| Number Of Permutations | 6393 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.022 |
| p-value | 0.949 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 47 |
| Number Of COSMIC SNVs | 14 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.04 |
| p-value | 0.272 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
