Assessment of Structural Intolerance and Durability
General Structure Information 1g55 TRDMT1 structure of human dnmt2, an enigmatic dna methyltransferase homologue 1.8Å AUTH A.DONG,J.A.YODER,X.ZHANG,L.ZHOU,T.H.BESTOR,X.CHENGTITL STRUCTURE OF HUMAN DNMT2, AN ENIGMATIC DNA METHYLTRANSFERASETITL 2 HOMOLOG THAT DISPLAYS DENATURANT-RESISTANT BINDING TO DNA.REF NUCLEIC ACIDS RES. V. 29 439 2001REFN ISSN 0305-1048PMID 11139614DOI 10.1093/NAR/29.2.439 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3mdy BMPR1B crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1b (bmpr1b) in complex with fkbp12 and ldn- 193189 2.05Å AUTH A.CHAIKUAD,C.SANVITALE,P.MAHAJAN,N.DAGA,C.COOPER,T.KROJER,AUTH 2 I.ALFANO,S.KNAPP,F.VON DELFT,J.WEIGELT,C.H.ARROWSMITH,AUTH 3 A.M.EDWARDS,C.BOUNTRA,A.BULLOCK,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE BONETITL 2 MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B (BMPR1B) IN […]
General Structure Information 4e3c IKBKB x-ray crystal structure of human ikk2 in an active conformation 3.98Å AUTH S.POLLEY,D.B.HUANG,A.V.HAUENSTEIN,A.J.FUSCO,X.ZHONG,D.VU,AUTH 2 A.HOFFMANN,I.V.VERMA,G.GHOSH,T.HUAFORDTITL X-RAY CRYSTAL STRUCTURE OF HUMAN IKK2 IN AN ACTIVETITL 2 CONFORMATIONREF PLOS.BIOL. 2013REFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3bqr DAPK3 crystal structure of human death associated protein kinase 3 (dapk3) in complex with an imidazo-pyridazine ligand 1.75Å AUTH P.FILIPPAKOPOULOS,P.RELLOS,O.FEDOROV,F.NIESEN,A.C.W.PIKE,AUTH 2 E.S.PILKA,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 3 S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN DEATH ASSOCIATED PROTEIN KINASE 3TITL 2 (DAPK3) IN COMPLEX WITH AN IMIDAZO-PYRIDAZINE LIGAND.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3mft CASK cask-4m cam kinase domain, mn2+ 2.2Å AUTH K.MUKHERJEE,M.SHARMA,R.JAHN,M.C.WAHL,T.C.SUDHOFTITL EVOLUTION OF CASK INTO A MG2+-SENSITIVE KINASE.REF SCI.SIGNAL. V. 3 RA33 2010REFN ESSN 1937-9145PMID 20424264DOI 10.1126/SCISIGNAL.2000800 Variant Set Distributions Mapped Variants
General Structure Information 1xnj PAPSS1 aps complex of human paps synthetase 1 1.98Å AUTH S.HARJES,P.BAYER,A.J.SCHEIDIGTITL THE CRYSTAL STRUCTURE OF HUMAN PAPS SYNTHETASE 1 REVEALSTITL 2 ASYMMETRY IN SUBSTRATE BINDINGREF J.MOL.BIOL. V. 347 623 2005REFN ISSN 0022-2836PMID 15755455DOI 10.1016/J.JMB.2005.01.005 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4c8b RIPK2 structure of the kinase domain of human ripk2 in complex with ponatinib 2.75Å AUTH P.CANNING,A.BULLOCKTITL STRUCTURE OF THE KINASE DOMAIN OF HUMAN RIPK2 IN COMPLEXTITL 2 WITH PONATINIBREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3epp RNMT crystal structure of mrna cap guanine-n7 methyltransferase (rnmt) in complex with sinefungin 2.41Å AUTH H.ZENG,M.F.AMAYA,P.LOPPNAU,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOTCHKAREV,J.MIN,A.N.PLOTNIKOV,AUTH 3 H.WUTITL CRYSTAL STRUCTURE OF MRNA CAP GUANINE-N7 METHYLTRANSFERASETITL 2 (RNMT) IN COMPLEX WITH SINEFUNGIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4a1g BUB1 the crystal structure of the human bub1 tpr domain in complex with the ki motif of knl1 2.6Å AUTH V.KRENN,A.WEHENKEL,X.LI,S.SANTAGUIDA,A.MUSACCHIOTITL STRUCTURAL ANALYSIS REVEALS FEATURES OF THE SPINDLETITL 2 CHECKPOINT KINASE BUB1-KINETOCHORE SUBUNIT KNL1TITL 3 INTERACTION.REF J.CELL BIOL. V. 196 451 2012REFN ISSN 0021-9525PMID 22331848DOI 10.1083/JCB.201110013 Variant Set Distributions Mapped Variants
General Structure Information 3keu PDXK crystal structure of human pl kinase with bound plp and atp 2.1Å AUTH A.K.GANDHI,F.N.MUSAYEV,M.K.SAFOTITL CRYSTAL STRUCTURE OF PL KINASE IN COMPLEX WITH MGATP ANDTITL 2 PLP: STRUCTURAL BASIS OF SEVERE INDUCED MGATP SUBSTRATETITL 3 INHIBITION OF THE ENZYMEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants