General Structure Information
| PDB ID | 3keu |
| HGNC Gene Label(s) | PDXK |
| Structure Name | crystal structure of human pl kinase with bound plp and atp |
| Resolution | 2.1Å |
| Reference | AUTH A.K.GANDHI,F.N.MUSAYEV,M.K.SAFOTITL CRYSTAL STRUCTURE OF PL KINASE IN COMPLEX WITH MGATP ANDTITL 2 PLP: STRUCTURAL BASIS OF SEVERE INDUCED MGATP SUBSTRATETITL 3 INHIBITION OF THE ENZYMEREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 305 |
| Number Of SNVs | 63 |
| Number Of Permutations | 8208 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.095 |
| p-value | 0.012 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 21:45139215 | V>I | B:14 | (15.23, 23.21, 36.29) | |
| 21:45153966 | rs191647922 | I>T | B:35 | (16.06, 10.99, 26.29) |
| 21:45153971 | A>T | B:37 | (20.22, 14.96, 28.66) | |
| 21:45153972 | rs372699159 | A>V | B:37 | (20.22, 14.96, 28.66) |
| 21:45161553 | rs543304336 | A>T | B:50 | (11.30, 36.38, 41.26) |
| 21:45161561 | W>C | B:52 | (17.16, 33.69, 37.72) | |
| 21:45161583 | D>H | B:60 | (34.18, 25.03, 25.12) | |
| 21:45161588 | E>D | B:61 | (31.66, 23.13, 29.00) | |
| 21:45161604 | E>K | B:67 | (35.30, 14.26, 22.36) | |
| 21:45161623 | N>S | B:73 | (31.36, 4.86, 19.20) | |
| 21:45161625 | M>L | B:74 | (28.35, 7.02, 22.87) | |
| 21:45161641 | Y>C | B:79 | (14.73, 11.41, 16.61) | |
| 21:45161643 | rs139005793 | V>M | B:80 | (18.44, 15.95, 17.74) |
| 21:45161650 | rs541151905 | T>I | B:82 | (17.04, 21.84, 20.06) |
| 21:45163611 | rs149442489 | T>M | B:85 | (19.60, 28.55, 22.76) |
| 21:45163620 | K>T | B:88 | (26.34, 33.17, 18.18) | |
| 21:45163631 | rs539421520 | A>S | B:92 | (27.31, 26.78, 16.59) |
| 21:45163637 | V>M | B:94 | (24.36, 22.66, 18.36) | |
| 21:45163645 | D>E | B:96 | (29.11, 21.87, 14.40) | |
| 21:45163646 | I>V | B:97 | (27.04, 18.43, 17.42) | |
| 21:45163667 | rs199941051 | Q>E | B:104 | (27.86, 8.82, 12.28) |
| 21:45163670 | N>D | B:105 | (22.22, 8.61, 11.12) | |
| 21:45163673 | P>T | B:106 | (21.86, 9.59, 7.42) | |
| 21:45163680 | L>P | B:108 | (19.25, 12.26, 12.46) | |
| 21:45165984 | K>R | B:119 | (2.87, 37.82, 20.43) | |
| 21:45165992 | G>S | B:122 | (0.16, 42.28, 20.66) | |
| 21:45166002 | rs77734576 | S>L | B:125 | (9.54, 40.46, 22.03) |
| 21:45166004 | rs545617906 | M>L | B:126 | (13.67, 38.71, 20.69) |
| 21:45166005 | rs147263135 | M>T | B:126 | (13.67, 38.71, 20.69) |
| 21:45168883 | P>L | B:129 | (20.41, 36.82, 21.66) | |
| 21:45168900 | V>I | B:135 | (22.54, 31.28, 13.26) | |
| 21:45168940 | T>M | B:148 | (8.28, 24.07, 16.78) | |
| 21:45168952 | F>Y | B:152 | (7.91, 36.66, 17.24) | |
| 21:45168960 | E>K | B:155 | (6.42, 36.62, 12.06) | |
| 21:45170394 | rs141434403 | R>W | B:160 | (7.16, 37.57, 4.69) |
| 21:45170395 | R>Q | B:160 | (7.16, 37.57, 4.69) | |
| 21:45170405 | H>Q | B:163 | (-1.55, 39.87, 9.43) | |
| 21:45170424 | rs376541440 | R>W | B:170 | (2.82, 33.16, 1.53) |
| 21:45170425 | R>Q | B:170 | (2.82, 33.16, 1.53) | |
| 21:45172429 | rs369091058 COSM1031181 COSM1031180 |
D>N | B:181 | (10.01, 18.19, 5.51) |
| 21:45172431 | rs372855286 | D>E | B:181 | (10.01, 18.19, 5.51) |
| 21:45172435 | V>M | B:183 | (6.22, 23.40, 9.78) | |
| 21:45172453 | rs201509716 | D>N | B:189 | (-3.15, 36.00, 17.24) |
| 21:45172460 | P>R | B:191 | (-8.63, 34.52, 13.45) | |
| 21:45172463 | S>F | B:192 | (-11.67, 31.66, 15.86) | |
| 21:45172466 | P>L | B:193 | (-14.59, 30.39, 14.26) | |
| 21:45173472 | rs201546479 | A>T | B:211 | (4.88, 6.05, -5.17) |
| 21:45173481 | rs202036508 | V>M | B:214 | (6.25, 14.96, -3.05) |
| 21:45173482 | V>A | B:214 | (6.25, 14.96, -3.05) | |
| 21:45173484 | rs367927142 | V>M | B:215 | (2.72, 14.84, -0.65) |
| 21:45173493 | rs371501001 | R>C | B:218 | (-1.60, 22.46, 4.50) |
| 21:45173499 | R>W | B:220 | (-6.97, 25.69, 11.97) | |
| 21:45173500 | COSM3357296 COSM3357297 |
R>Q | B:220 | (-6.97, 25.69, 11.97) |
| 21:45173511 | R>C | B:224 | (-10.13, 26.94, 25.99) | |
| 21:45173512 | rs61737063 | R>H | B:224 | (-10.13, 26.94, 25.99) |
| 21:45173523 | A>T | B:228 | (-2.51, 31.55, 32.29) | |
| 21:45173546 | rs370764393 | D>E | B:235 | (9.62, 22.92, 25.78) |
| 21:45173561 | M>I | B:240 | (5.24, 14.89, 22.72) | |
| 21:45173579 | rs372098146 | H>Q | B:246 | (8.57, 7.58, 15.89) |
| 21:45173583 | H>Y | B:248 | (1.30, 8.35, 14.15) | |
| 21:45173590 | N>S | B:250 | (2.84, 9.05, 6.98) | |
| 21:45175603 | rs145229797 | T>A | B:262 | (-0.91, 15.68, 25.92) |
| 21:45175604 | rs77602696 | T>I | B:262 | (-0.91, 15.68, 25.92) |
| 21:45175610 | H>R | B:264 | (-6.44, 19.55, 27.54) | |
| 21:45175612 | H>Y | B:265 | (-5.34, 15.81, 29.06) | |
| 21:45175859 | S>I | B:285 | (2.04, 31.36, 41.35) | |
| 21:45175880 | R>Q | B:292 | (0.78, 18.55, 38.67) | |
| 21:45175906 | rs553591640 | E>K | B:301 | (1.28, 6.29, 28.74) |
| 21:45175917 | E>D | B:304 | (-9.05, 11.39, 25.88) | |
| 21:45175921 | rs367592470 | V>I | B:306 | (-9.92, 16.42, 23.51) |
| 21:45175924 | rs150472480 | V>I | B:307 | (-8.86, 18.48, 19.83) |
| 21:45175937 | V>G | B:311 | (-8.30, 19.13, 6.99) |