General Structure Information
| PDB ID | 4f9a |
| HGNC Gene Label(s) | CDC7 |
| Structure Name | human cdc7 kinase in complex with dbf4 and nucleotide |
| Resolution | 2.17Å |
| Reference | AUTH S.HUGHES,F.ELUSTONDO,A.DI FONZO,F.G.LEROUX,A.C.WONG,AUTH 2 A.P.SNIJDERS,S.J.MATTHEWS,P.CHEREPANOVTITL CRYSTAL STRUCTURE OF HUMAN CDC7 KINASE IN COMPLEX WITH ITSTITL 2 ACTIVATOR DBF4.REF NAT.STRUCT.MOL.BIOL. V. 19 1101 2012REFN ISSN 1545-9993PMID 23064647DOI 10.1038/NSMB.2404 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 317 |
| Number Of SNVs | 72 |
| Number Of Permutations | 35652 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.036 |
| p-value | 0.887 |
COSMIC
| Number Of Residues | 317 |
| Number Of SNVs | 4 |
| Number Of Permutations | 269 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.5 |
| p-value | 0.032 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 72 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.919 |
| p-value | 0.008 |