General Structure Information
| PDB ID | 1ksw |
| HGNC Gene Label(s) | SRC |
| Structure Name | structure of human c-src tyrosine kinase (thr338gly mutant) in complex with n6-benzyl adp |
| Resolution | 2.8Å |
| Reference | AUTH L.A.WITUCKI,X.HUANG,K.SHAH,Y.LIU,S.KYIN,M.J.ECK,AUTH 2 K.M.SHOKATTITL MUTANT TYROSINE KINASES WITH UNNATURAL NUCLEOTIDETITL 2 SPECIFICITY RETAIN THE STRUCTURE ANDTITL 3 PHOSPHO-ACCEPTOR SPECIFICITY OF THE WILD-TYPETITL 4 ENZYME.REF CHEM.BIOL. V. 9 25 2002REFN ISSN 1074-5521PMID 11841936DOI 10.1016/S1074-5521(02)00091-1 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 449 |
| Number Of SNVs | 53 |
| Number Of Permutations | 27764 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.067 |
| p-value | 0.259 |
COSMIC
| Number Of Residues | 449 |
| Number Of SNVs | 3 |
| Number Of Permutations | 261 |
| Optimal Distance Threshold | 49.0 |
| K Statistic | 0.667 |
| p-value | 0.57 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 53 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 30.0 |
| K Statistic | -0.422 |
| p-value | 0.335 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
