Assessment of Structural Intolerance and Durability
General Structure Information 4dnl PRKCA crystal structure of a c2 domain of a protein kinase c alpha (prkca) from homo sapiens at 1.90 a resolution 1.9Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 2 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL CRYSTAL STRUCTURE OF A C2 DOMAIN OF A PROTEIN KINASE C ALPHATITL 2 (PRKCA) FROM HOMO […]
General Structure Information 3uiu EIF2AK2 crystal structure of apo-pkr kinase domain 2.9Å AUTH F.LI,S.LI,X.YANG,Y.SHEN,T.ZHANGTITL CRYSTAL STRUCTURE OF APO-PKR KINASE DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2y7j PHKG2 structure of human phosphorylase kinase, gamma 2 2.5Å AUTH J.R.C.MUNIZ,A.SHRESTHA,P.SAVITSKY,J.WANG,P.RELLOS,O.FEDOROV,AUTH 2 N.BURGESS-BROWN,B.BRENNER,G.BERRIDGE,J.M.ELKINS,T.KROJER,AUTH 3 M.VOLLMAR,K.H.CHE,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 4 J.WEIGELT,C.BOUNTRA,S.KNAPPTITL STRUCTURE OF HUMAN PHOSPHORYLASE KINASE, GAMMA 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4js2 ST6GAL1 crystal structure of human beta-galactoside alpha-2,6- sialyltransferase 1 in complex with cmp 2.3Å AUTH B.KUHN,J.BENZ,M.GREIF,A.M.ENGEL,H.SOBEK,M.G.RUDOLPHTITL THE STRUCTURE OF HUMAN ALPHA-2,6-SIALYLTRANSFERASE REVEALSTITL 2 THE BINDING MODE OF COMPLEX GLYCANSREF ACTA CRYSTALLOGR.,SECT.D V. 69 1826 2013REFN ISSN 0907-4449DOI 10.1107/S0907444913015412 Variant Set Distributions Mapped Variants
General Structure Information 1k6m PFKFB1 crystal structure of human liver 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2.4Å AUTH Y.H.LEE,Y.LI,K.UYEDA,C.A.HASEMANNTITL TISSUE-SPECIFIC STRUCTURE/FUNCTION DIFFERENTIATION OF THETITL 2 LIVER ISOFORM OFTITL 3 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE.REF J.BIOL.CHEM. V. 278 523 2003REFN ISSN 0021-9258PMID 12379646DOI 10.1074/JBC.M209105200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1qu6 EIF2AK2 structure of the double-stranded rna-binding domain of the protein kinase pkr reveals the molecular basis of its dsrna-mediated activation -1.0Å AUTH S.NANDURI,B.W.CARPICK,Y.YANG,B.R.WILLIAMS,J.QINTITL STRUCTURE OF THE DOUBLE-STRANDED RNA-BINDINGTITL 2 DOMAIN OF THE PROTEIN KINASE PKR REVEALS THETITL 3 MOLECULAR BASIS OF ITS DSRNA-MEDIATED ACTIVATION.REF EMBO J. V. 17 5458 1998REFN ISSN […]
General Structure Information 3owp PRKACA human camp-dependent protein kinase in complex with an inhibitor 1.88Å AUTH H.KOESTER,T.CRAAN,S.BRASS,A.HEINE,G.KLEBETITL FRAGMENT BASED DRUG DESIGN ON PKAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ii5 BRAF the complex of wild-type b-raf with pyrazolo pyrimidine inhibitor 2.79Å AUTH D.M.BERGER,N.TORRES,M.DUTIA,D.POWELL,G.CISZEWSKI,AUTH 2 A.GOPALSAMY,J.I.LEVIN,K.H.KIM,W.XU,J.WILHELM,Y.HU,AUTH 3 K.COLLINS,L.FELDBERG,S.KIM,E.FROMMER,AUTH 4 D.WOJCIECHOWICZ,R.MALLONTITL NON-HINGE-BINDING PYRAZOLO[1,5-A]PYRIMIDINES ASTITL 2 POTENT B-RAF KINASE INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 19 6519 2009REFN ISSN 0960-894XPMID 19864136DOI 10.1016/J.BMCL.2009.10.049 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3iw4 PRKCA crystal structure of pkc alpha in complex with nvp-aeb071 2.8Å AUTH J.WAGNER,P.VON MATT,R.SEDRANI,R.ALBERT,N.COOKE,C.EHRHARDT,AUTH 2 M.GEISER,G.RUMMEL,W.STARK,A.STRAUSS,S.W.COWAN-JACOB,AUTH 3 C.BEERLI,G.WECKBECKER,J.P.EVENOU,G.ZENKE,S.COTTENSTITL DISCOVERY OFTITL 2 3-(1H-INDOL-3-YL)-4-[2-(4-METHYLPIPERAZIN-1-YL)QUINAZOLIN-4-TITL 3 YL]PYRROLE-2,5-DIONE (AEB071), A POTENT AND SELECTIVETITL 4 INHIBITOR OF PROTEIN KINASE C ISOTYPESREF J.MED.CHEM. V. 52 6193 2009REFN ISSN 0022-2623PMID 19827831DOI 10.1021/JM901108B Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3dyd TAT human tyrosine aminotransferase 2.3Å AUTH T.KARLBERG,M.MOCHE,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 T.KOTENYOVA,L.LEHTIO,M.E.NILSSON,P.NORDLUND,T.NYMAN,AUTH 5 K.OLESEN,C.PERSSON,J.SAGEMARK,A.G.THORSELL,L.TRESAUGUES,AUTH 6 S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WIKSTROM,M.WISNIEWSKA,AUTH 7 H.SCHULER,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL HUMAN TYROSINE AMINOTRANSFERASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants