Assessment of Structural Intolerance and Durability
General Structure Information 1nn1 DTYMK crystal structure of human thymidylate kinase with ddtmp and appnhp 1.9Å AUTH N.OSTERMANN,D.SEGURA-PENA,C.MEIER,T.VEIT,M.MONNERJAHN,AUTH 2 M.KONRAD,A.LAVIETITL STRUCTURES OF HUMAN THYMIDYLATE KINASE IN COMPLEX WITHTITL 2 PRODRUGS: IMPLICATIONS FOR THE STRUCTURE-BASED DESIGN OFTITL 3 NOVEL COMPOUNDSREF BIOCHEMISTRY V. 42 2568 2003REFN ISSN 0006-2960PMID 12614151DOI 10.1021/BI027302T Variant Set Distributions Mapped Variants
General Structure Information 3epz DNMT1 structure of the replication foci-targeting sequence of human dna cytosine methyltransferase dnmt1 2.31Å AUTH F.SYEDA,R.L.FAGAN,M.WEAN,G.V.AVVAKUMOV,J.R.WALKER,S.XUE,AUTH 2 S.DHE-PAGANON,C.BRENNERTITL THE REPLICATION FOCUS TARGETING SEQUENCE (RFTS) DOMAIN IS ATITL 2 DNA-COMPETITIVE INHIBITOR OF DNMT1.REF J.BIOL.CHEM. V. 286 15344 2011REFN ISSN 0021-9258PMID 21389349DOI 10.1074/JBC.M110.209882 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1w98 CCNE1 the structural basis of cdk2 activation by cyclin e 2.15Å AUTH R.HONDA,E.D.LOWE,E.DUBININA,V.SKAMNAKI,A.COOK,N.BROWN,AUTH 2 L.N.JOHNSONTITL THE STRUCTURE OF CYCLIN E1/CDK2: IMPLICATIONS FOR CDK2TITL 2 ACTIVATION AND CDK2-INDEPENDENT ROLESREF EMBO J. V. 24 452 2005REFN ISSN 0261-4189PMID 15660127DOI 10.1038/SJ.EMBOJ.7600554 Variant Set Distributions Mapped Variants
General Structure Information 1tuz DGKA nmr structure of the diacylglycerol kinase alpha, nesgc target hr532 -1.0Å AUTH G.LIU,Y.SHAO,R.XIAO,T.ACTON,G.T.MONTELIONE,AUTH 2 T.SZYPERSKITITL NMR STRUCTURE OF DIACYLGLYCEROL KINASE ALPHA,TITL 2 NESGC TARGET HR532REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2zoq MAPK3 structural dissection of human mitogen-activated kinase erk1 2.39Å AUTH T.KINOSHITA,I.YOSHIDA,S.NAKAE,K.OKITA,M.GOUDA,AUTH 2 M.MATSUBARA,K.YOKOTA,H.ISHIGURO,T.TADATITL CRYSTAL STRUCTURE OF HUMAN MONO-PHOSPHORYLATEDTITL 2 ERK1 AT TYR204REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 377 1123 2008REFN ISSN 0006-291XPMID 18983981DOI 10.1016/J.BBRC.2008.10.127 Variant Set Distributions Mapped Variants
General Structure Information 3g33 CCND3 crystal structure of cdk4/cyclin d3 3.0Å AUTH T.TAKAKI,A.ECHALIER,N.R.BROWN,T.HUNT,J.A.ENDICOTT,M.E.NOBLETITL THE STRUCTURE OF CDK4/CYCLIN D3 HAS IMPLICATIONS FOR MODELSTITL 2 OF CDK ACTIVATION.REF PROC.NATL.ACAD.SCI.USA V. 106 4171 2009REFN ISSN 0027-8424PMID 19237555DOI 10.1073/PNAS.0809674106 Variant Set Distributions Mapped Variants
General Structure Information 1rby GART human gar tfase complex structure with 10-(trifluoroacetyl)- 5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid and substrate beta-gar 2.1Å AUTH Y.ZHANG,J.DESHARNAIS,D.L.BOGER,I.A.WILSONTITL HUMAN GAR TFASE COMPLEX STRUCTUREREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4fxf PKM structure of m2 pyruvate kinase in complex with phenylalanine 2.55Å AUTH H.P.MORGAN,F.J.OREILLY,M.A.WEAR,J.R.ONEILL,AUTH 2 L.A.FOTHERGILL-GILMORE,T.HUPP,M.D.WALKINSHAWTITL M2 PYRUVATE KINASE PROVIDES A MECHANISM FOR NUTRIENT SENSINGTITL 2 AND REGULATION OF CELL PROLIFERATION.REF PROC.NATL.ACAD.SCI.USA V. 110 5881 2013REFN ISSN 0027-8424PMID 23530218DOI 10.1073/PNAS.1217157110 Variant Set Distributions Mapped Variants
General Structure Information 4fpa HK1 crystal structure of recombinant human hexokinase type i mutant d413n glucose 6-phosphate 2.48Å AUTH L.SHEN,Y.GAO,R.B.HONZATKOTITL DETERMINATION OF SITE AFFINITY CONSTANTS FOR PRODUCTTITL 2 INHIBITION OF WILD-TYPE AND MUTANT FORMS OF RECOMBINANTTITL 3 HUMAN HEXOKINASE TYPE IREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3dre CKB crystal structure of human brain-type creatine kinase 2.2Å AUTH S.M.BONG,J.H.MOON,K.H.NAM,K.S.LEE,Y.M.CHI,K.Y.HWANGTITL STRUCTURAL STUDIES OF HUMAN BRAIN-TYPE CREATINETITL 2 KINASE COMPLEXED WITH THE ADP-MG2+-NO3- -CREATINETITL 3 TRANSITION-STATE ANALOGUE COMPLEXREF FEBS LETT. V. 582 3959 2008REFN ISSN 0014-5793PMID 18977227DOI 10.1016/J.FEBSLET.2008.10.039 Variant Set Distributions Mapped Variants