General Structure Information
| PDB ID | 3n46 |
| HGNC Gene Label(s) | FDPS |
| Structure Name | human fpps complex with nov_980 and zoledronic acid/mg2+ |
| Resolution | 2.35Å |
| Reference | AUTH W.JAHNKE,J.M.RONDEAU,S.COTESTA,A.MARZINZIK,X.PELLE,M.GEISER,AUTH 2 A.STRAUSS,M.GOTTE,F.BITSCH,R.HEMMIG,C.HENRY,S.LEHMANN,AUTH 3 J.F.GLICKMAN,T.P.RODDY,S.J.STOUT,J.R.GREENTITL ALLOSTERIC NON-BISPHOSPHONATE FPPS INHIBITORS IDENTIFIED BYTITL 2 FRAGMENT-BASED DISCOVERY.REF NAT.CHEM.BIOL. V. 6 660 2010REFN ISSN 1552-4450PMID 20711197DOI 10.1038/NCHEMBIO.421 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 343 |
| Number Of SNVs | 84 |
| Number Of Permutations | 42086 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.048 |
| p-value | 0.97 |
COSMIC
| Number Of Residues | 343 |
| Number Of SNVs | 5 |
| Number Of Permutations | 226 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.1 |
| p-value | 0.794 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 84 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.211 |
| p-value | 0.557 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
