Assessment of Structural Intolerance and Durability
General Structure Information 3gub DAPK1 crystal structure of dapkl93g complexed with n6-(2- phenylethyl)adenosine 1.71Å AUTH L.K.MCNAMARA,J.S.SCHAVOCKY,D.M.WATTERSON,AUTH 2 J.S.BRUNZELLETITL CRYSTAL STRUCTURES OF THE DAPK GATEKEEPER MUTANTTITL 2 COMPLEXED WITH N6-MODIFIED ADENOSINE ANALOGS.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2yn8 EPHB4 ephb4 kinase domain inhibitor complex 2.11Å AUTH R.C.OVERMAN,I.GREEN,C.M.TRUMAN,J.A.READ,K.J.EMBREY,AUTH 2 M.S.B.MCALISTER,T.K.ATTWOODTITL STABILITY AND SOLUBILITY ENGINEERING OF THE EPHB4 TYROSINETITL 2 KINASE CATALYTIC DOMAIN USING A RATIONALLY DESIGNEDTITL 3 SYNTHETIC LIBRARY.REF PROTEIN ENG.DES.SEL. V. 26 695 2013REFN ISSN 1741-0126PMID 23840071DOI 10.1093/PROTEIN/GZT032 Variant Set Distributions Mapped Variants
General Structure Information 1ua2 CDK7 crystal structure of human cdk7 3.02Å AUTH G.LOLLI,E.D.LOWE,N.R.BROWN,L.N.JOHNSONTITL THE CRYSTAL STRUCTURE OF HUMAN CDK7 AND ITS PROTEINTITL 2 RECOGNITION PROPERTIESREF STRUCTURE V. 12 2067 2004REFN ISSN 0969-2126PMID 15530371DOI 10.1016/J.STR.2004.08.013 Variant Set Distributions Mapped Variants
General Structure Information 2e7h EPHB4 solution structure of the second fn3 domain from human ephrin type-b receptor 4 -1.0Å AUTH X.R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND FN3 DOMAIN FROMTITL 2 HUMAN EPHRIN TYPE-B RECEPTOR 4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3enm MAP2K6 the structure of the map2k mek6 reveals an autoinhibitory dimer 2.35Å AUTH X.MIN,R.AKELLA,H.HE,J.M.HUMPHREYS,S.E.TSUTAKAWA,S.J.LEE,AUTH 2 J.A.TAINER,M.H.COBB,E.J.GOLDSMITHTITL THE STRUCTURE OF THE MAP2K MEK6 REVEALS AN AUTOINHIBITORYTITL 2 DIMERREF STRUCTURE V. 17 96 2009REFN ISSN 0969-2126PMID 19141286DOI 10.1016/J.STR.2008.11.007 Variant Set Distributions Mapped Variants
General Structure Information 1cm8 MAPK12 phosphorylated map kinase p38-gamma 2.4Å AUTH S.BELLON,M.J.FITZGIBBON,T.FOX,H.M.HSIAO,K.P.WILSONTITL THE STRUCTURE OF PHOSPHORYLATED P38GAMMA ISTITL 2 MONOMERIC AND REVEALS A CONSERVED ACTIVATION-LOOPTITL 3 CONFORMATION.REF STRUCTURE FOLD.DES. V. 7 1057 1999REFN ISSN 0969-2126PMID 10508788DOI 10.1016/S0969-2126(99)80173-7 Variant Set Distributions Mapped Variants
General Structure Information 3wef FDFT1 crystal structure of the human squalene synthase in complex with farnesyl thiopyrophosphate 2.35Å AUTH C.I.LIU,W.Y.JENG,W.J.CHANG,M.F.SHIH,T.P.KO,A.H.J.WANGTITL STRUCTURAL INSIGHTS INTO THE CATALYTIC MECHANISM OF HUMANTITL 2 SQUALENE SYNTHASEREF ACTA CRYSTALLOGR.,SECT.D V. 70 231 2014REFN ISSN 0907-4449DOI 10.1107/S1399004713026230 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4ip7 PKLR structure of the s12d variant of human liver pyruvate kinase in complex with citrate and fbp. 1.8Å AUTH T.HOLYOAK,B.ZHANG,J.DENG,Q.TANG,C.B.PRASANNAN,A.W.FENTONTITL ENERGETIC COUPLING BETWEEN AN OXIDIZABLE CYSTEINE AND THETITL 2 PHOSPHORYLATABLE N-TERMINUS OF HUMAN LIVER PYRUVATE KINASE.REF BIOCHEMISTRY V. 52 466 2013REFN ISSN 0006-2960PMID 23270483DOI 10.1021/BI301341R Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2rd0 PIK3CA structure of a human p110alpha/p85alpha complex 3.05Å AUTH C.H.HUANG,D.MANDELKER,O.SCHMIDT-KITTLER,Y.SAMUELS,AUTH 2 V.E.VELCULESCU,K.W.KINZLER,B.VOGELSTEIN,S.B.GABELLI,AUTH 3 L.M.AMZELTITL THE STRUCTURE OF A HUMAN P110ALPHA/P85ALPHA COMPLEXTITL 2 ELUCIDATES THE EFFECTS OF ONCOGENIC PI3KALPHA MUTATIONS.REF SCIENCE V. 318 1744 2007REFN ISSN 0036-8075PMID 18079394DOI 10.1126/SCIENCE.1150799 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2lul TEC solution nmr structure of ph domain of tyrosine-protein kinase tec from homo sapiens, northeast structural genomics consortium (nesg) target hr3504c -1.0Å AUTH G.LIU,R.XIAO,H.JANJUA,K.HAMILTON,R.SHASTRY,E.KOHAN,AUTH 2 T.B.ACTON,J.K.EVERETT,H.LEE,K.PEDERSON,Y.J.HUANG,AUTH 3 G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF PH DOMAIN OF TYROSINE-PROTEINTITL 2 KINASE TEC FROM HOMO SAPIENS, NORTHEAST STRUCTURAL GENOMICSTITL 3 CONSORTIUM (NESG) TARGET HR3504CREF TO […]