General Structure Information 2kk1 ABL2 solution structure of c-terminal domain of tyrosine-protein kinase abl2 from homo sapiens, northeast structural genomics consortium (nesg) target hr5537a -1.0Å AUTH G.LIU,Y.J.HUANG,R.XIAO,D.WANG,T.B.ACTON,AUTH 2 G.T.MONTELIONETITL NMR STRUCTURE OF F-ACTIN-BINDING DOMAIN OF ARG/ABL2TITL 2 FROM HOMO SAPIENS.REF PROTEINS V. 78 1326 2010REFN ISSN 0887-3585PMID 20077570DOI 10.1002/PROT.22656 Variant Set Distributions Mapped Variants
General Structure Information 3rod NNMT methyltransferase 2.72Å AUTH Y.PENG,D.SARTINI,V.POZZI,D.WILK,M.EMANUELLI,V.C.YEETITL STRUCTURAL BASIS OF SUBSTRATE RECOGNITION IN HUMANTITL 2 NICOTINAMIDE N-METHYLTRANSFERASE.REF BIOCHEMISTRY V. 50 7800 2011REFN ISSN 0006-2960PMID 21823666DOI 10.1021/BI2007614 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3a8w PRKCI crystal structure of pkciota kinase domain 2.1Å AUTH T.TAKIMURA,K.KAMATA,K.FUKASAWA,H.OHSAWA,H.KOMATANI,AUTH 2 T.YOSHIZUMI,I.TAKAHASHI,H.KOTANI,Y.IWASAWATITL STRUCTURES OF THE PKC-IOTA KINASE DOMAIN IN ITS ATP-BOUNDTITL 2 AND APO FORMS REVEAL DEFINED STRUCTURES OF RESIDUES 533-551TITL 3 IN THE C-TERMINAL TAIL AND THEIR ROLES IN ATP BINDINGREF ACTA CRYSTALLOGR.,SECT.D V. 66 577 2010REFN ISSN 0907-4449PMID 20445233DOI […]
General Structure Information 3evs GDF5 crystal structure of the gdf-5:bmp receptor ib complex. 2.1Å AUTH A.KOTZSCH,J.NICKEL,A.SEHER,W.SEBALD,T.D.MULLERTITL CRYSTAL STRUCTURE ANALYSIS REVEALS A SPRING-LOADED LATCH ASTITL 2 MOLECULAR MECHANISM FOR GDF-5-TYPE I RECEPTOR SPECIFICITY.REF EMBO J. V. 28 937 2009REFN ISSN 0261-4189PMID 19229295DOI 10.1038/EMBOJ.2009.37 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3alo MAP2K4 crystal structure of human non-phosphorylated mkk4 kinase domain ternary complex with amp-pnp and p38 peptide 2.6Å AUTH T.MATSUMOTO,T.KINOSHITA,Y.KIRII,K.YOKOTA,K.HAMADA,T.TADATITL CRYSTAL STRUCTURES OF MKK4 KINASE DOMAIN REVEAL THATTITL 2 SUBSTRATE PEPTIDE BINDS TO AN ALLOSTERIC SITE AND INDUCES ANTITL 3 AUTO-INHIBITION STATEREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 400 369 2010REFN ISSN 0006-291XPMID 20732303DOI 10.1016/J.BBRC.2010.08.071 Variant […]
General Structure Information 4cga CHKA human choline kinase a1 in complex with compound 5 1.74Å AUTH B.RUBIO-RUIZ,A.FIGUEROLA-CONCHAS,J.RAMOS-TORRECILLAS,AUTH 2 F.CAPITAN-CANADAS,P.RIOS-MARCO,M.P.CARRASCO,M.A.GALLO,AUTH 3 A.ESPINOSA,C.MARCO,C.CONCEPCION,A.ENTRENA-GUADIX,AUTH 4 R.HURTADO-GUERRERO,A.CONEJO-GARCIATITL DISCOVERY OF A NEW BINDING SITE ON HUMAN CHOLINE KINASE A1:TITL 2 DESIGN, SYNTHESIS, CRYSTALLOGRAPHIC STUDIES AND BIOLOGICALTITL 3 EVALUATION OF ASYMMETRICAL BISPYRIDINIUM DERIVATIVESREF J.MED.CHEM. V. 57 507 2014REFN ISSN 0022-2623PMID 24387243DOI […]
General Structure Information 2x7o TGFBR1 crystal structure of tgfbri complexed with an indolinone inhibitor 3.7Å AUTH G.J.ROTH,A.HECKEL,T.BRANDL,M.GRAUERT,S.HOERER,J.T.KLEY,AUTH 2 G.SCHNAPP,P.BAUM,D.MENNERICH,A.SCHNAPP,J.E.PARKTITL DESIGN, SYNTHESIS AND EVALUATION OF INDOLINONES ASTITL 2 INHIBITORS OF THE TRANSFORMING GROWTH FACTOR BETA RECEPTORTITL 3 I (TGFBRI)REF J.MED.CHEM. V. 53 7287 2010REFN ISSN 0022-2623PMID 20919678DOI 10.1021/JM100812A Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2m59 KDR spatial structure of dimeric vegfr2 membrane domain in dpc micelles -1.0Å AUTH K.S.MINEEV,A.S.ARSENIEV,M.A.SHULEPKO,E.N.LYUKMANOVATITL SPATIAL STRUCTURE OF DIMERIC VEGFR2 MEMBRANE DOMAIN IN DPCTITL 2 MICELLESREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4fl2 SYK structural and biophysical characterization of the syk activation switch 2.19Å AUTH U.GRADLER,D.SCHWARZ,V.DRESING,D.MUSIL,J.BOMKE,M.FRECH,AUTH 2 H.GREINER,S.JAKEL,T.RYSIOK,D.MULLER-POMPALLA,A.WEGENERTITL STRUCTURAL AND BIOPHYSICAL CHARACTERIZATION OF THE SYKTITL 2 ACTIVATION SWITCH.REF J.MOL.BIOL. V. 425 309 2013REFN ISSN 0022-2836PMID 23154170DOI 10.1016/J.JMB.2012.11.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1pkx ATIC crystal structure of human atic in complex with xmp 1.9Å AUTH D.W.WOLAN,C.G.CHEONG,S.E.GREASLEY,I.A.WILSONTITL STRUCTURAL INSIGHTS INTO THE HUMAN AND AVIAN IMPTITL 2 CYCLOHYDROLASE MECHANISM VIA CRYSTAL STRUCTURESTITL 3 WITH THE BOUND XMP INHIBITOR.REF BIOCHEMISTRY V. 43 1171 2004REFN ISSN 0006-2960PMID 14756553DOI 10.1021/BI030162I Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]