Assessment of Structural Intolerance and Durability
General Structure Information 1f05 TALDO1 crystal structure of human transaldolase 2.45Å AUTH S.THORELL,P.GERGELY JR.,K.BANKI,A.PERL,G.SCHNEIDERTITL THE THREE-DIMENSIONAL STRUCTURE OF HUMANTITL 2 TRANSALDOLASE.REF FEBS LETT. V. 475 205 2000REFN ISSN 0014-5793PMID 10869557DOI 10.1016/S0014-5793(00)01658-6 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4jsp MTOR structure of mtordeltan-mlst8-atpgammas-mg complex 3.3Å AUTH H.YANG,D.G.RUDGE,J.D.KOOS,B.VAIDIALINGAM,H.J.YANG,AUTH 2 N.P.PAVLETICHTITL MTOR KINASE STRUCTURE, MECHANISM AND REGULATION.REF NATURE V. 497 217 2013REFN ISSN 0028-0836PMID 23636326DOI 10.1038/NATURE12122 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4eih ABL2 crystal structure of arg sh2 domain 1.2Å AUTH S.M.GIFFORD,W.LIU,C.C.MADER,T.L.HALO,K.MACHIDA,T.J.BOGGON,AUTH 2 A.J.KOLESKETITL TWO AMINO ACID RESIDUES CONFER DIFFERENT BINDING AFFINITIESTITL 2 OF ABELSON FAMILY KINASE SRC HOMOLOGY 2 DOMAINS FORTITL 3 PHOSPHORYLATED CORTACTIN.REF J.BIOL.CHEM. V. 289 19704 2014REFN ISSN 0021-9258PMID 24891505DOI 10.1074/JBC.M114.556480 Variant Set Distributions Mapped Variants
General Structure Information 1vd2 PRKCI solution structure of the pb1 domain of pkciota -1.0Å AUTH Y.HIRANO,S.YOSHINAGA,K.OGURA,M.YOKOCHI,Y.NODA,AUTH 2 H.SUMIMOTO,F.INAGAKITITL SOLUTION STRUCTURE OF ATYPICAL PROTEIN KINASE CTITL 2 PB1 DOMAIN AND ITS MODE OF INTERACTION WITHTITL 3 ZIP/P62 AND MEK5REF J.BIOL.CHEM. V. 279 31883 2004REFN ISSN 0021-9258PMID 15143057DOI 10.1074/JBC.M403092200 Variant Set Distributions Mapped Variants
General Structure Information 2jdr AKT2 structure of pkb-beta (akt2) complexed with the inhibitor a- 443654 2.3Å AUTH T.G.DAVIES,M.L.VERDONK,B.GRAHAM,S.SAALAU-BETHELL,AUTH 2 C.C.F.HAMLETT,T.MCHARDY,I.COLLINS,M.D.GARRETT,AUTH 3 P.WORKMAN,S.J.WOODHEAD,H.JHOTI,D.BARFORDTITL A STRUCTURAL COMPARISON OF INHIBITOR BINDING TOTITL 2 PKB, PKA AND PKA-PKB CHIMERAREF J.MOL.BIOL. V. 367 882 2007REFN ISSN 0022-2836PMID 17275837DOI 10.1016/J.JMB.2007.01.004 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4bsj FLT4 crystal structure of vegfr-3 extracellular domains d4-5 2.5Å AUTH V.-M.LEPPANEN,D.TVOROGOV,K.KISKO,A.E.PROTA,M.JELTSCH,AUTH 2 A.ANISIMOV,S.MARKOVIC-MUELLER,E.STUTTFELD,K.N.GOLDIE,AUTH 3 K.BALLMER-HOFER,K.ALITALOTITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO VEGFR-3 LIGANDTITL 2 BINDING AND ACTIVATIONREF PROC.NATL.ACAD.SCI.USA V. 110 12960 2013REFN ISSN 0027-8424PMID 23878260DOI 10.1073/PNAS.1301415110 Variant Set Distributions Mapped Variants
General Structure Information 2dm0 TXK solution structure of the sh2 domain of human tyrosine- protein kinase txk -1.0Å AUTH H.ENDO,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH2 DOMAIN OF HUMANTITL 2 TYROSINE-PROTEIN KINASE TXKREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3npc MAPK9 crystal structure of jnk2 complexed with birb796 2.35Å AUTH A.KUGLSTATTER,M.GHATE,S.TSING,A.G.VILLASENOR,D.SHAW,AUTH 2 J.W.BARNETT,M.F.BROWNERTITL X-RAY CRYSTAL STRUCTURE OF JNK2 COMPLEXED WITH THE P38ALPHATITL 2 INHIBITOR BIRB796: INSIGHTS INTO THE RATIONAL DESIGN OFTITL 3 DFG-OUT BINDING MAP KINASE INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 20 5217 2010REFN ISSN 0960-894XPMID 20655210DOI 10.1016/J.BMCL.2010.06.157 Variant Set Distributions Ripley’s K […]
General Structure Information 3hmn TTK crystal structure of human mps1 catalytic domain in complex with atp 2.7Å AUTH M.L.CHU,Z.LANG,L.M.CHAVAS,J.NERES,O.S.FEDOROVA,L.TABERNERO,AUTH 2 M.CHERRY,D.H.WILLIAMS,K.T.DOUGLAS,P.A.EYERSTITL BIOPHYSICAL AND X-RAY CRYSTALLOGRAPHIC ANALYSIS OF MPS1TITL 2 KINASE INHIBITOR COMPLEXES.REF BIOCHEMISTRY V. 49 1689 2010REFN ISSN 0006-2960PMID 20099905DOI 10.1021/BI901970C Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3ou5 SHMT2 human mitochondrial serine hydroxymethyltransferase 2 2.04Å AUTH H.WU,A.DONG,H.ZENG,P.LOPPNAU,M.SUNDSTROM,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOV,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL SERINETITL 2 HYDROXYMETHYLTRANSFERASE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants