4JSP.B | MTOR – ASTRID

4JSP.B | MTOR

General Structure Information

PDB ID	4jsp
HGNC Gene Label(s)	MTOR
Structure Name	structure of mtordeltan-mlst8-atpgammas-mg complex
Resolution	3.3Å
Reference	AUTH H.YANG,D.G.RUDGE,J.D.KOOS,B.VAIDIALINGAM,H.J.YANG,AUTH 2 N.P.PAVLETICHTITL MTOR KINASE STRUCTURE, MECHANISM AND REGULATION.REF NATURE V. 497 217 2013REFN ISSN 0028-0836PMID 23636326DOI 10.1038/NATURE12122

Variant Set Distributions

ExAC Variants

Number Of Residues	1058
Number Of SNVs	130
Number Of Permutations	39048
Optimal Distance Threshold	29.0
K Statistic	0.197
p-value	0.109

COSMIC

Number Of Residues	1058
Number Of SNVs	35
Number Of Permutations	40247
Optimal Distance Threshold	22.0
K Statistic	0.2
p-value	0.01

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	130
Number Of COSMIC SNVs	30
Optimal Distance Threshold	21.0
K Statistic	0.099
p-value	0.026

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
1:11259396		R>Q	B:1391	(-21.85, -16.38, -26.30)
1:11259337		A>S	B:1411	(-9.26, 3.37, -31.21)
1:11227570		N>Y	B:1420	(-8.43, -10.86, -30.67)
1:11227551	rs35509012 COSM1332652	P>L	B:1426	(-2.60, -15.08, -30.90)
1:11227542		A>V	B:1429	(-3.59, -9.91, -33.15)
1:11217347		E>G	B:1444	(5.86, 7.01, -32.21)
1:11217296	rs146570474	V>A	B:1461	(19.94, -2.49, -32.75)
1:11217285		K>Q	B:1465	(20.39, 4.19, -34.56)
1:11217279	rs201769627	M>V	B:1467	(20.06, 5.82, -26.76)
1:11217263		D>G	B:1472	(19.81, 10.19, -21.54)
1:11217248		M>T	B:1477	(16.54, 3.08, -20.18)
1:11217239	COSM1332646	R>H	B:1480	(19.17, -1.19, -24.13)
1:11217225		E>Q	B:1485	(13.93, -8.77, -19.22)
1:11210277		Q>H	B:1492	(24.23, -5.81, -21.98)
1:11210278	rs145440700	Q>R	B:1492	(24.23, -5.81, -21.98)
1:11210260		C>Y	B:1498	(24.65, 0.12, -12.30)
1:11210249	COSM3782339	T>A	B:1502	(21.20, 9.38, -12.18)
1:11206806		R>Q	B:1538	(7.84, -6.74, 0.98)
1:11206807	rs202187935	R>W	B:1538	(7.84, -6.74, 0.98)
1:11206774		V>L	B:1549	(14.99, -17.10, -4.63)
1:11206768		A>T	B:1551	(15.87, -17.79, 1.02)
1:11205053	rs376251080	A>V	B:1579	(-9.82, -8.75, -16.83)
1:11205039	rs566232327	S>C	B:1584	(1.93, -12.53, -22.56)
1:11204809		M>V	B:1590	(1.58, -21.37, -16.86)
1:11204769		I>T	B:1603	(11.81, -26.32, -1.00)
1:11204763		Y>C	B:1605	(16.97, -31.38, -4.74)
1:11204751	rs200634566	P>R	B:1609	(17.53, -36.76, 1.08)
1:11204752		P>A	B:1609	(17.53, -36.76, 1.08)
1:11204749	rs199612643	E>K	B:1610	(13.75, -40.23, -1.10)
1:11204742	COSM423456	R>Q	B:1612	(18.59, -36.06, -4.82)
1:11204736	rs56299586	I>T	B:1614	(11.01, -38.57, -8.14)
1:11204737		I>V	B:1614	(11.01, -38.57, -8.14)
1:11204731	rs17848545	R>C	B:1616	(17.49, -35.24, -11.41)
1:11199705		R>H	B:1628	(6.91, -23.38, -21.57)
1:11199669	rs573705289	R>Q	B:1640	(15.28, -26.94, -13.09)
1:11199670	COSM1687000	R>W	B:1640	(15.28, -26.94, -13.09)
1:11199666	COSM3471240	S>F	B:1641	(20.30, -23.65, -10.99)
1:11199664		L>V	B:1642	(18.95, -22.85, -6.78)
1:11199658		V>I	B:1644	(21.54, -28.93, -10.28)
1:11199652		P>T	B:1646	(25.11, -27.37, -15.44)
1:11199647	rs144984370	H>Q	B:1647	(28.67, -29.14, -15.15)
1:11199648		H>R	B:1647	(28.67, -29.14, -15.15)
1:11199607		G>S	B:1661	(18.89, -23.17, -32.62)
1:11199600	rs199682978	S>N	B:1663	(14.75, -20.82, -32.37)
1:11199491		A>G	B:1667	(24.46, -16.63, -29.13)
1:11199443		R>Q	B:1683	(38.16, -16.65, -26.08)
1:11199431	rs376436419	H>R	B:1687	(43.94, -24.14, -30.67)
1:11199428		P>L	B:1688	(42.06, -28.08, -31.52)
1:11199419		T>R	B:1691	(37.17, -34.69, -26.83)
1:11199416		V>A	B:1692	(36.16, -33.55, -22.65)
1:11199406		Q>H	B:1695	(27.12, -35.47, -27.16)
1:11199396		A>T	B:1699	(26.75, -29.26, -30.57)
1:11199389		M>T	B:1701	(30.79, -29.10, -34.50)
1:11199368		A>V	B:1708	(28.88, -18.72, -40.04)
1:11194520		D>N	B:1712	(35.91, -24.05, -39.15)
1:11194498		H>R	B:1719	(40.35, -33.38, -37.54)
1:11194484		M>V	B:1724	(35.71, -40.15, -31.43)
1:11194467	rs140288227	Q>H	B:1729	(40.67, -48.40, -31.84)
1:11194457	rs201557303	A>T	B:1733	(38.15, -51.86, -21.93)
1:11194444		Q>L	B:1737	(29.70, -52.34, -24.52)
1:11194441		Q>P	B:1738	(26.53, -48.74, -21.53)
1:11194439		H>Y	B:1739	(31.43, -44.97, -23.72)
1:11194424		H>Y	B:1744	(30.04, -46.84, -32.33)
1:11193251		C>W	B:1750	(29.19, -37.29, -37.15)
1:11193222	rs562084232	N>S	B:1760	(26.28, -27.37, -48.60)
1:11193206		N>K	B:1765	(30.95, -33.75, -58.23)
1:11193196	COSM1258050	I>V	B:1769	(29.62, -39.06, -55.91)
1:11193177		Y>C	B:1775	(31.83, -39.11, -45.22)
1:11193178		Y>H	B:1775	(31.83, -39.11, -45.22)
1:11193171		S>N	B:1777	(28.58, -46.21, -45.38)
1:11193169		A>T	B:1778	(29.78, -45.07, -42.19)
1:11193166		A>T	B:1779	(26.60, -44.22, -40.86)
1:11193160		E>K	B:1781	(28.44, -49.67, -41.05)
1:11193156		H>R	B:1782	(29.31, -46.71, -36.96)
1:11193150	COSM893815	R>H	B:1784	(23.73, -51.86, -39.62)
1:11193151	rs371091288	R>C	B:1784	(23.73, -51.86, -39.62)
1:11190596		K>T	B:1868	(33.85, -47.96, -74.37)
1:11190590	rs536888206	T>S	B:1870	(26.73, -47.39, -73.43)
1:11189886		K>E	B:1875	(29.99, -50.83, -66.55)
1:11189882		T>I	B:1876	(28.15, -46.19, -64.02)
1:11189856	rs139043855	V>I	B:1885	(17.36, -50.80, -54.70)
1:11189840	rs373213788	R>H	B:1890	(18.44, -52.37, -44.77)
1:11189822		R>Q	B:1896	(5.37, -50.43, -40.59)
1:11188975		W>C	B:1916	(20.23, -53.37, -66.33)
1:11188964		N>S	B:1920	(15.50, -58.32, -60.54)
1:11188609		V>I	B:1938	(1.88, -47.86, -54.35)
1:11188557		R>H	B:1955	(8.51, -62.42, -64.65)
1:11188537		T>A	B:1962	(-0.74, -62.19, -56.28)
1:11188531		I>V	B:1964	(-1.09, -57.55, -52.31)
1:11188527		G>A	B:1965	(-4.27, -60.57, -52.53)
1:11188152	rs567800666	K>T	B:1981	(-13.32, -53.46, -67.26)
1:11188143		T>M	B:1984	(-5.24, -52.44, -73.65)
1:11188135	COSM4020621	R>W	B:1987	(-3.58, -52.94, -68.58)
1:11188129		N>D	B:1989	(-4.88, -60.32, -70.51)
1:11188116	rs373390383	K>R	B:1993	(-3.93, -63.57, -65.62)
1:11188111		L>V	B:1995	(-8.71, -61.32, -60.83)
1:11188075	COSM3471198	Q>E	B:2007	(-17.14, -63.02, -58.91)
1:11188066	rs369201808	M>V	B:2010	(-16.42, -58.40, -61.45)
1:11187769	rs371511548	N>S	B:2043	(-16.23, -37.39, -91.42)
1:11187719		R>W	B:2060	(-24.03, -56.32, -76.49)
1:11187694		T>I	B:2068	(-36.54, -52.90, -72.85)
1:11187159		K>E	B:2087	(-28.91, -49.26, -98.19)
1:11187151	rs542723817	M>I	B:2089	(-21.67, -48.45, -96.35)
1:11187140		N>S	B:2093	(-26.37, -42.33, -102.99)
1:11187130		D>E	B:2096	(-29.30, -44.28, -99.32)
1:11186804		R>Q	B:2134	(-29.71, -57.21, -49.10)
1:11186766	rs370987224	N>D	B:2147	(-5.90, -50.88, -38.42)
1:11186754		I>V	B:2151	(-17.24, -51.47, -43.60)
1:11186750		R>H	B:2152	(-18.52, -56.14, -45.33)
1:11186751	COSM2119231	R>C	B:2152	(-18.52, -56.14, -45.33)
1:11186732		P>L	B:2158	(-33.53, -47.80, -53.99)
1:11186730	rs373553027	S>T	B:2159	(-33.19, -44.29, -55.38)
1:11186711		S>C	B:2165	(-25.83, -31.28, -65.23)
1:11186697		R>W	B:2170	(-26.19, -40.73, -62.09)
1:11184684		N>S	B:2178	(-21.75, -49.92, -39.91)
1:11184679		H>Y	B:2180	(-23.43, -45.61, -39.93)
1:11184597	rs373990757 COSM3471173	T>S	B:2207	(1.10, -36.65, -42.53)
1:11184576		T>I	B:2214	(2.90, -25.27, -35.70)
1:11184571		L>F	B:2216	(-0.95, -30.29, -34.72)
1:11182140		L>V	B:2236	(-17.39, -43.76, -57.18)
1:11182128		V>L	B:2240	(-18.57, -34.09, -48.34)
1:11182037		R>Q	B:2270	(-25.55, -2.03, -69.09)
1:11181418		P>L	B:2273	(-20.17, -4.07, -75.01)
1:11181365		V>I	B:2291	(-16.06, -4.08, -57.68)
1:11181361	rs374052581	N>S	B:2292	(-16.48, 0.07, -57.05)
1:11177130	rs371628273	R>Q	B:2316	(-18.64, -22.10, -38.13)
1:11177113		R>C	B:2322	(-6.28, -21.48, -39.52)
1:11175505		L>P	B:2346	(-17.82, -23.49, -47.56)
1:11174491		N>I	B:2395	(-4.88, -16.15, -39.14)
1:11174386		R>K	B:2430	(-2.62, -34.70, -67.12)
1:11172968		T>N	B:2436	(-6.22, -27.54, -77.60)
1:11169383		I>V	B:2498	(11.30, -32.70, -67.74)
1:11169379	rs143119651	Q>R	B:2499	(8.88, -28.31, -68.81)
1:11168340	COSM1747620	R>Q	B:2511	(15.24, -21.01, -58.09)
1:11168336		D>E	B:2512	(8.70, -19.45, -58.15)
1:11168332	rs370135897	S>A	B:2514	(13.39, -15.21, -60.16)
1:11168311	rs529777655	V>I	B:2521	(8.56, -18.42, -47.32)
1:11168299	rs377231271	V>I	B:2525	(3.79, -15.78, -49.59)
1:11168277	COSM4020596	A>G	B:2532	(-4.03, -13.27, -56.35)

[+] COSMIC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
1:11227551	COSM1332652	P>L	B:1426	(-2.60, -15.08, -30.90)
1:11227530	COSM212841	L>S	B:1433	(0.49, -4.77, -34.77)
1:11217299	COSM462618	L>P	B:1460	(18.74, -3.99, -28.86)
1:11217261	COSM1756829	D>H	B:1473	(15.71, 9.99, -23.37)
1:11217234	COSM2119573	R>C	B:1482	(11.36, -3.05, -21.74)
1:11217230	COSM462615	C>Y	B:1483	(15.07, -6.02, -24.95)
1:11217231	COSM3747775	C>R	B:1483	(15.07, -6.02, -24.95)
1:11210263	COSM1667142	C>F	B:1497	(21.32, -0.79, -13.90)
1:11205096	COSM1756828	D>H	B:1565	(1.90, -19.01, -0.41)
1:11204730	COSM180794	R>H	B:1616	(17.49, -35.24, -11.41)
1:11190824	COSM1215724	A>V	B:1792	(21.03, -40.97, -47.09)
1:11190804	COSM180789	E>K	B:1799	(20.94, -37.85, -56.32)
1:11190797	COSM1197082	V>G	B:1801	(21.85, -42.80, -61.11)
1:11189841	COSM1332635	R>C	B:1890	(18.44, -52.37, -44.77)
1:11188578	COSM2119252	T>M	B:1948	(5.42, -53.94, -68.45)
1:11188183	COSM1289946	A>T	B:1971	(-6.99, -53.33, -51.81)
1:11188177	COSM423441	I>F	B:1973	(-11.09, -55.98, -55.92)
1:11188164	COSM462602	T>R	B:1977	(-12.11, -54.87, -61.94)
1:11188078	COSM249481	V>F	B:2006	(-13.59, -61.56, -57.32)
1:11188061	COSM1560107	M>I	B:2011	(-21.90, -57.24, -60.17)
1:11188063	COSM20684	M>V	B:2011	(-21.90, -57.24, -60.17)
1:11187758	COSM3704832	M>V	B:2047	(-20.44, -40.77, -88.87)
1:11187730	COSM893802	A>V	B:2056	(-23.16, -53.16, -81.08)
1:11187102	COSM1600544	H>Y	B:2106	(-37.89, -39.18, -84.64)
1:11184573	COSM1686998	S>F	B:2215	(0.53, -27.37, -38.25)
1:11182067	COSM124531	L>H	B:2260	(-29.07, -9.74, -60.40)
1:11177096	COSM1662881	M>I	B:2327	(-5.58, -25.89, -50.81)
1:11175467	COSM4990400	G>R	B:2359	(-8.21, -31.33, -64.07)
1:11174428	COSM1719540	A>V	B:2416	(7.79, -38.43, -55.28)
1:11174426	COSM249753	V>M	B:2417	(3.93, -38.03, -55.18)
1:11174420	COSM4187184	E>K	B:2419	(8.51, -37.38, -60.02)
1:11174395	COSM2119114	L>R	B:2427	(-2.05, -40.21, -66.25)
1:11174383	COSM1161896	L>P	B:2431	(0.31, -32.72, -70.60)
1:11169375	COSM462582	I>M	B:2500	(5.55, -30.09, -65.41)
1:11169374	COSM4140746	I>F	B:2501	(8.62, -32.03, -62.44)
1:11169361	COSM3722599	R>L	B:2505	(12.58, -29.07, -58.50)
1:11168340	COSM1747620	R>Q	B:2511	(15.24, -21.01, -58.09)
1:11168338	COSM893755	D>Y	B:2512	(8.70, -19.45, -58.15)
1:11168301	COSM893752	Q>L	B:2524	(7.20, -17.57, -52.14)