General Structure Information
| PDB ID | 2jdr |
| HGNC Gene Label(s) | AKT2 |
| Structure Name | structure of pkb-beta (akt2) complexed with the inhibitor a- 443654 |
| Resolution | 2.3Å |
| Reference | AUTH T.G.DAVIES,M.L.VERDONK,B.GRAHAM,S.SAALAU-BETHELL,AUTH 2 C.C.F.HAMLETT,T.MCHARDY,I.COLLINS,M.D.GARRETT,AUTH 3 P.WORKMAN,S.J.WOODHEAD,H.JHOTI,D.BARFORDTITL A STRUCTURAL COMPARISON OF INHIBITOR BINDING TOTITL 2 PKB, PKA AND PKA-PKB CHIMERAREF J.MOL.BIOL. V. 367 882 2007REFN ISSN 0022-2836PMID 17275837DOI 10.1016/J.JMB.2007.01.004 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 303 |
| Number Of SNVs | 57 |
| Number Of Permutations | 27402 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.245 |
| p-value | 0.166 |
COSMIC
| Number Of Residues | 303 |
| Number Of SNVs | 6 |
| Number Of Permutations | 1007 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.2 |
| p-value | 0.289 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 57 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 28.0 |
| K Statistic | 0.313 |
| p-value | 0.588 |