Assessment of Structural Intolerance and Durability
General Structure Information 3o96 AKT1 crystal structure of human akt1 with an allosteric inhibitor 2.7Å AUTH W.I.WU,W.C.VOEGTLI,H.L.STURGIS,F.P.DIZON,G.P.VIGERS,AUTH 2 B.J.BRANDHUBERTITL CRYSTAL STRUCTURE OF HUMAN AKT1 WITH AN ALLOSTERIC INHIBITORTITL 2 REVEALS A NEW MODE OF KINASE INHIBITION.REF PLOS ONE V. 5 12913 2010REFN ESSN 1932-6203PMID 20886116DOI 10.1371/JOURNAL.PONE.0012913 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2lcr ACVRL1 nmr structure of alk1 extracellular domain -1.0Å AUTH P.MAHLAWAT,U.ILANGOVAN,A.HINCKTITL NMR SOLUTION STRUCTURE OF ALK1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1s9i MAP2K2 x-ray structure of the human mitogen-activated protein kinase kinase 2 (mek2)in a complex with ligand and mgatp 3.2Å AUTH J.F.OHREN,H.CHEN,A.PAVLOVSKY,C.WHITEHEAD,E.ZHANG,AUTH 2 P.KUFFA,C.YAN,P.MCCONNELL,C.SPESSARD,C.BANOTAI,AUTH 3 W.T.MUELLER,A.DELANEY,C.OMER,J.SEBOLT-LEOPOLD,AUTH 4 D.T.DUDLEY,I.K.LEUNG,C.FLAMME,J.WARMUS,M.KAUFMAN,AUTH 5 S.BARRETT,H.TECLE,C.A.HASEMANNTITL STRUCTURES OF HUMAN MAP KINASE KINASE 1 (MEK1) ANDTITL 2 MEK2 DESCRIBE NOVEL NONCOMPETITIVE KINASETITL 3 INHIBITION.REF NAT.STRUCT.MOL.BIOL. V. 11 1192 2004REFN […]
General Structure Information 3d7u CSK structural basis for the recognition of c-src by its inactivator csk 4.11Å AUTH N.M.LEVINSON,M.A.SEELIGER,P.A.COLE,J.KURIYANTITL STRUCTURAL BASIS FOR THE RECOGNITION OF C-SRC BY ITSTITL 2 INACTIVATOR CSK.REF CELL(CAMBRIDGE,MASS.) V. 134 124 2008REFN ISSN 0092-8674PMID 18614016DOI 10.1016/J.CELL.2008.05.051 Variant Set Distributions Mapped Variants
General Structure Information 3be2 KDR crystal structure of the vegfr2 kinase domain in complex with a benzamide inhibitor 1.75Å AUTH J.C.HARMANGE,M.M.WEISS,J.GERMAIN,A.J.POLVERINO,AUTH 2 G.BORG,J.BREADY,D.CHEN,D.CHOQUETTE,A.COXON,AUTH 3 T.DEMELFI,L.DIPIETRO,N.DOERR,J.ESTRADA,J.FLYNN,AUTH 4 R.F.GRACEFFA,S.P.HARRIMAN,S.KAUFMAN,D.S.LA,A.LONG,AUTH 5 M.W.MARTIN,S.NEERVANNAN,V.F.PATEL,M.POTASHMAN,AUTH 6 K.REGAL,P.M.ROVETO,M.L.SCHRAG,C.STARNES,A.TASKER,AUTH 7 Y.TEFFERA,L.WANG,R.D.WHITE,D.A.WHITTINGTON,R.ZANONTITL NAPHTHAMIDES AS NOVEL AND POTENT VASCULARTITL 2 ENDOTHELIAL GROWTH FACTOR RECEPTOR TYROSINE KINASETITL 3 INHIBITORS: DESIGN, SYNTHESIS, AND EVALUATION.REF J.MED.CHEM. V. 51 […]
General Structure Information 2p02 MAT2A crystal structure of the alpha subunit of human s- adenosylmethionine synthetase 2 1.21Å AUTH E.PAPAGRIGORIOU,N.SHAFQAT,A.ROJKOVA,F.H.NIESSEN,AUTH 2 K.L.KAVANAGH,F.VON DELFT,F.GORREC,E.UGOCHUKWU,AUTH 3 C.H.ARROWSMITH,A.EDWARDS,J.WEIGELT,M.SUNDSTROM,AUTH 4 U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT OF HUMANTITL 2 S-ADENOSYLMETHIONINE SYNTHETASE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3d42 PTPN7 crystal structure of heptp in complex with a monophosphorylated erk2 peptide 2.46Å AUTH D.A.CRITTON,A.TORTAJADA,G.STETSON,W.PETI,R.PAGETITL STRUCTURAL BASIS OF SUBSTRATE RECOGNITION BY HEMATOPOIETICTITL 2 TYROSINE PHOSPHATASE.REF BIOCHEMISTRY V. 47 13336 2008REFN ISSN 0006-2960PMID 19053285DOI 10.1021/BI801724N Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1bj4 SHMT1 recombinant serine hydroxymethyltransferase (human) 2.65Å AUTH S.B.RENWICK,K.SNELL,U.BAUMANNTITL THE CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC SERINETITL 2 HYDROXYMETHYLTRANSFERASE: A TARGET FOR CANCER CHEMOTHERAPYREF STRUCTURE V. 6 1105 1998REFN ISSN 0969-2126PMID 9753690DOI 10.1016/S0969-2126(98)00112-9 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ozo ZAP70 autoinhibited intact human zap-70 2.6Å AUTH S.DEINDL,T.A.KADLECEK,T.BRDICKA,X.CAO,A.WEISS,AUTH 2 J.KURIYANTITL STRUCTURAL BASIS FOR THE INHIBITION OF TYROSINETITL 2 KINASE ACTIVITY OF ZAP-70.REF CELL(CAMBRIDGE,MASS.) V. 129 735 2007REFN ISSN 0092-8674PMID 17512407DOI 10.1016/J.CELL.2007.03.039 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1rjb FLT3 crystal structure of flt3 2.1Å AUTH J.GRIFFITH,J.BLACK,C.FAERMAN,L.SWENSON,M.WYNN,F.LU,AUTH 2 J.LIPPKE,K.SAXENATITL THE STRUCTURAL BASIS FOR AUTOINHIBITION OF FLT3 BYTITL 2 THE JUXTAMEMBRANE DOMAIN.REF MOL.CELL V. 13 169 2004REFN ISSN 1097-2765PMID 14759363DOI 10.1016/S1097-2765(03)00505-7 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants