General Structure Information
| PDB ID | 1s9i |
| HGNC Gene Label(s) | MAP2K2 |
| Structure Name | x-ray structure of the human mitogen-activated protein kinase kinase 2 (mek2)in a complex with ligand and mgatp |
| Resolution | 3.2Å |
| Reference | AUTH J.F.OHREN,H.CHEN,A.PAVLOVSKY,C.WHITEHEAD,E.ZHANG,AUTH 2 P.KUFFA,C.YAN,P.MCCONNELL,C.SPESSARD,C.BANOTAI,AUTH 3 W.T.MUELLER,A.DELANEY,C.OMER,J.SEBOLT-LEOPOLD,AUTH 4 D.T.DUDLEY,I.K.LEUNG,C.FLAMME,J.WARMUS,M.KAUFMAN,AUTH 5 S.BARRETT,H.TECLE,C.A.HASEMANNTITL STRUCTURES OF HUMAN MAP KINASE KINASE 1 (MEK1) ANDTITL 2 MEK2 DESCRIBE NOVEL NONCOMPETITIVE KINASETITL 3 INHIBITION.REF NAT.STRUCT.MOL.BIOL. V. 11 1192 2004REFN ISSN 1545-9993PMID 15543157DOI 10.1038/NSMB859 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 291 |
| Number Of SNVs | 54 |
| Number Of Permutations | 9703 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.021 |
| p-value | 0.294 |
ClinVar
| Number Of Residues | 291 |
| Number Of SNVs | 8 |
| Number Of Permutations | 1259 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.179 |
| p-value | 0.052 |
Ripley’s K Analysis Plots
ExACClinVar
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 54 |
| Number Of ClinVar SNVs | 6 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.201 |
| p-value | 0.116 |