General Structure Information
| PDB ID | 2ozo |
| HGNC Gene Label(s) | ZAP70 |
| Structure Name | autoinhibited intact human zap-70 |
| Resolution | 2.6Å |
| Reference | AUTH S.DEINDL,T.A.KADLECEK,T.BRDICKA,X.CAO,A.WEISS,AUTH 2 J.KURIYANTITL STRUCTURAL BASIS FOR THE INHIBITION OF TYROSINETITL 2 KINASE ACTIVITY OF ZAP-70.REF CELL(CAMBRIDGE,MASS.) V. 129 735 2007REFN ISSN 0092-8674PMID 17512407DOI 10.1016/J.CELL.2007.03.039 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 538 |
| Number Of SNVs | 111 |
| Number Of Permutations | 61221 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.047 |
| p-value | 0.777 |
ClinVar
| Number Of Residues | 538 |
| Number Of SNVs | 4 |
| Number Of Permutations | 1041 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.5 |
| p-value | 0.278 |
COSMIC
| Number Of Residues | 538 |
| Number Of SNVs | 16 |
| Number Of Permutations | 7420 |
| Optimal Distance Threshold | 37.0 |
| K Statistic | 0.392 |
| p-value | 0.178 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 111 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.357 |
| p-value | 0.277 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 111 |
| Number Of COSMIC SNVs | 15 |
| Optimal Distance Threshold | 43.0 |
| K Statistic | -0.178 |
| p-value | 0.139 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
