4CFF.A | PRKAA2

General Structure Information 4cff PRKAA2 structure of full length human ampk in complex with a small molecule activator, a thienopyridone derivative (a-769662) 3.92Å AUTH B.XIAO,M.J.SANDERS,D.CARMENA,N.J.BRIGHT,L.F.HAIRE,AUTH 2 E.UNDERWOOD,B.R.PATEL,R.B.HEATH,P.A.WALKER,S.HALLEN,AUTH 3 F.GIORDANETTO,S.R.MARTIN,D.CARLING,S.J.GAMBLINTITL STRUCTURAL BASIS OF AMPK REGULATION BY SMALL MOLECULETITL 2 ACTIVATORS.REF NAT.COMMUN. V. 4 3017 2013REFN ISSN 2041-1723PMID 24352254DOI 10.1038/NCOMMS4017 Variant Set Distributions Ripley’s K Analysis Plots […]

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2YBX.A | PIP4K2A

General Structure Information 2ybx PIP4K2A crystal structure of human phosphatidylinositol-5-phosphate 4-kinase type-2 alpha 2.56Å AUTH L.TRESAUGUES,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,T.EKBLAD,S.FLODIN,S.GRASLUND,AUTH 3 T.KARLBERG,T.KOTENYOVA,E.KOUZNETSOVA,T.NYMAN,C.PERSSON,AUTH 4 H.SCHULER,M.I.SIPONEN,A.G.THORSELL,E.WAHLBERG,J.WEIGELT,AUTH 5 P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN PHOSPHATIDYLINOSITOL-5-TITL 2 PHOSPHATE 4-KINASE TYPE-2 ALPHAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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2W5A.A | NEK2

General Structure Information 2w5a NEK2 human nek2 kinase adp-bound 1.55Å AUTH I.WESTWOOD,D.M.CHEARY,J.E.BAXTER,M.W.RICHARDS,AUTH 2 R.L.VAN MONTFORT,A.M.FRY,R.BAYLISSTITL INSIGHTS INTO THE CONFORMATIONAL VARIABILITY ANDTITL 2 REGULATION OF HUMAN NEK2 KINASE.REF J.MOL.BIOL. V. 386 476 2009REFN ISSN 0022-2836PMID 19124027DOI 10.1016/J.JMB.2008.12.033 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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4A6E.A | ASMT

General Structure Information 4a6e ASMT crystal structure of human n-acetylserotonin methyltransferase (asmt) in complex with sam and n-acetylserotonin 2.7Å AUTH H.G.BOTROS,P.LEGRAND,C.PAGAN,V.BONDET,P.WEBER,AUTH 2 M.BEN-ABDALLAH,N.LEMIERE,G.HUGUET,J.BELLALOU,E.MARONDE,AUTH 3 P.BEGUIN,A.HAOUZ,W.SHEPARD,T.BOURGERONTITL CRYSTAL STRUCTURE AND FUNCTIONAL MAPPING OF HUMAN ASMT, THETITL 2 LAST ENZYME OF THE MELATONIN SYNTHESIS PATHWAY.REF J.PINEAL RES. V. 54 46 2013REFN ISSN 0742-3098PMID 22775292DOI 10.1111/J.1600-079X.2012.01020.X Variant Set Distributions […]

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3E0J.E | POLD2

General Structure Information 3e0j POLD2 x-ray structure of the complex of regulatory subunits of human dna polymerase delta 3.0Å AUTH A.G.BARANOVSKIY,N.D.BABAYEVA,V.G.LISTON,AUTH 2 I.B.ROGOZIN,E.V.KOONIN,Y.I.PAVLOV,D.G.VASSYLYEV,AUTH 3 T.H.TAHIROVTITL X-RAY STRUCTURE OF THE COMPLEX OF REGULATORYTITL 2 SUBUNITS OF HUMAN DNA POLYMERASE DELTA.REF CELL CYCLE V. 7 3026 2008REFN ISSN 1538-4101PMID 18818516 Variant Set Distributions Mapped Variants

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4A4L.A | PLK1

General Structure Information 4a4l PLK1 crystal structure of polo-like kinase 1 in complex with a 5-(2-amino-pyrimidin-4-yl)-1h-pyrrole inhibitor 2.35Å AUTH M.CARUSO,B.VALSASINA,D.BALLINARI,J.A.BERTRAND,M.G.BRASCA,AUTH 2 M.CALDARELLI,P.CAPPELLA,F.FIORENTINI,L.M.GIANELLINI,AUTH 3 A.SCOLARO,I.BERIATITL 5-(2-AMINO-PYRIMIDIN-4-YL)-1H-PYRROLE AND 2-(2-AMINO-TITL 2 PYRIMIDIN-4-YL)-1,5,6,7-TETRAHYDRO-PYRROLO[3,2-C]PYRIDIN-4-TITL 3 ONE DERIVATIVES AS NEW CLASSES OF SELECTIVE AND ORALLYTITL 4 AVAILABLE POLO-LIKE KINASE 1 INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 22 96 2012REFN ISSN 0960-894XPMID 22154349DOI 10.1016/J.BMCL.2011.11.065 Variant […]

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1LS6.A | SULT1A1

General Structure Information 1ls6 SULT1A1 human sult1a1 complexed with pap and p-nitrophenol 1.9Å AUTH N.U.GAMAGE,R.G.DUGGLEBY,A.C.BARNETT,M.TRESILLIAN,AUTH 2 C.F.LATHAM,N.E.LIYOU,M.E.MCMANUS,J.L.MARTINTITL STRUCTURE OF A HUMAN CARCINOGEN-CONVERTING ENZYME,TITL 2 SULT1A1. STRUCTURAL AND KINETIC IMPLICATIONS OFTITL 3 SUBSTRATE INHIBITION.REF J.BIOL.CHEM. V. 278 7655 2003REFN ISSN 0021-9258PMID 12471039DOI 10.1074/JBC.M207246200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]

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4M4R.C | EPHA4

General Structure Information 4m4r EPHA4 epha4 ectodomain complex with ephrin a5 3.13Å AUTH K.XU,D.TZVETKOVA-ROBEV,Y.XU,Y.GOLDGUR,Y.P.CHAN,J.P.HIMANEN,AUTH 2 D.B.NIKOLOVTITL INSIGHTS INTO EPH RECEPTOR TYROSINE KINASE ACTIVATION FROMTITL 2 CRYSTAL STRUCTURES OF THE EPHA4 ECTODOMAIN AND ITS COMPLEXTITL 3 WITH EPHRIN-A5.REF PROC.NATL.ACAD.SCI.USA V. 110 14634 2013REFN ISSN 0027-8424PMID 23959867DOI 10.1073/PNAS.1311000110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]

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2R2P.A | EPHA5

General Structure Information 2r2p EPHA5 kinase domain of human ephrin type-a receptor 5 (epha5) 2.4Å AUTH J.R.WALKER,D.CUERRIER,C.BUTLER-COLE,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL KINASE DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 5TITL 2 (EPHA5).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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3NR9.B | CLK2

General Structure Information 3nr9 CLK2 structure of human cdc2-like kinase 2 (clk2) 2.89Å AUTH A.CHAIKUAD,P.SAVITSKY,T.KROJER,J.R.C.MUNIZ,AUTH 2 P.FILIPPAKOPOULOS,P.RELLOS,T.KEATES,O.FEDOROV,A.C.W.PIKE,AUTH 3 J.ESWARAN,G.BERRIDGE,C.PHILLIPS,Y.ZHANG,F.VON DELFT,AUTH 4 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,S.KNAPP,AUTH 5 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL STRUCTURE OF HUMAN CDC2-LIKE KINASE 2 (CLK2)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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