General Structure Information
| PDB ID | 4cff |
| HGNC Gene Label(s) | PRKAA2 |
| Structure Name | structure of full length human ampk in complex with a small molecule activator, a thienopyridone derivative (a-769662) |
| Resolution | 3.92Å |
| Reference | AUTH B.XIAO,M.J.SANDERS,D.CARMENA,N.J.BRIGHT,L.F.HAIRE,AUTH 2 E.UNDERWOOD,B.R.PATEL,R.B.HEATH,P.A.WALKER,S.HALLEN,AUTH 3 F.GIORDANETTO,S.R.MARTIN,D.CARLING,S.J.GAMBLINTITL STRUCTURAL BASIS OF AMPK REGULATION BY SMALL MOLECULETITL 2 ACTIVATORS.REF NAT.COMMUN. V. 4 3017 2013REFN ISSN 2041-1723PMID 24352254DOI 10.1038/NCOMMS4017 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 424 |
| Number Of SNVs | 76 |
| Number Of Permutations | 60464 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.032 |
| p-value | 0.428 |
COSMIC
| Number Of Residues | 424 |
| Number Of SNVs | 13 |
| Number Of Permutations | 11958 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.064 |
| p-value | 0.64 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 76 |
| Number Of COSMIC SNVs | 14 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | -0.023 |
| p-value | 0.723 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
