General Structure Information
| PDB ID | 2r2p |
| HGNC Gene Label(s) | EPHA5 |
| Structure Name | kinase domain of human ephrin type-a receptor 5 (epha5) |
| Resolution | 2.4Å |
| Reference | AUTH J.R.WALKER,D.CUERRIER,C.BUTLER-COLE,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL KINASE DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 5TITL 2 (EPHA5).REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 276 |
| Number Of SNVs | 65 |
| Number Of Permutations | 31841 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.276 |
| p-value | 0.222 |
COSMIC
| Number Of Residues | 276 |
| Number Of SNVs | 14 |
| Number Of Permutations | 4553 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.044 |
| p-value | 0.523 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 65 |
| Number Of COSMIC SNVs | 10 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | -0.051 |
| p-value | 0.812 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
