1CM8.B | MAPK12

General Structure Information

PDB ID	1cm8
HGNC Gene Label(s)	MAPK12
Structure Name	phosphorylated map kinase p38-gamma
Resolution	2.4Å
Reference	AUTH S.BELLON,M.J.FITZGIBBON,T.FOX,H.M.HSIAO,K.P.WILSONTITL THE STRUCTURE OF PHOSPHORYLATED P38GAMMA ISTITL 2 MONOMERIC AND REVEALS A CONSERVED ACTIVATION-LOOPTITL 3 CONFORMATION.REF STRUCTURE FOLD.DES. V. 7 1057 1999REFN ISSN 0969-2126PMID 10508788DOI 10.1016/S0969-2126(99)80173-7

Variant Set Distributions

ExAC Variants

Number Of Residues	327
Number Of SNVs	113
Number Of Permutations	47248
Optimal Distance Threshold	21.0
K Statistic	0.347
p-value	0.347

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
22:50699902	rs200538586	R>S	B:1013	(0.86, 24.79, 63.60)
22:50699886		K>R	B:1018	(-6.12, 31.64, 55.79)
22:50699883		T>M	B:1019	(-2.83, 30.01, 55.63)
22:50699868		R>P	B:1024	(12.89, 26.35, 62.07)
22:50699847		Q>R	B:1031	(3.40, 39.95, 60.52)
22:50699844		P>L	B:1032	(1.56, 39.34, 56.77)
22:50699845		P>S	B:1032	(1.56, 39.34, 56.77)
22:50699723		S>L	B:1043	(7.52, 39.11, 58.47)
22:50699684		K>R	B:1056	(8.25, 31.91, 50.19)
22:50699679		L>V	B:1058	(6.30, 26.76, 48.73)
22:50699672		R>L	B:1060	(1.06, 23.15, 47.44)
22:50699669	rs147345964	P>L	B:1061	(4.38, 22.12, 46.46)
22:50699660		S>F	B:1064	(1.35, 19.36, 40.44)
22:50699654		L>R	B:1066	(3.42, 23.09, 36.82)
22:50699645	rs368055751	K>M	B:1069	(8.74, 22.01, 37.08)
22:50699624		R>H	B:1076	(19.06, 23.36, 42.10)
22:50699625	rs138533200	R>C	B:1076	(19.06, 23.36, 42.10)
22:50699615		K>R	B:1079	(20.52, 25.99, 46.93)
22:50699606		R>H	B:1082	(25.49, 34.73, 44.31)
22:50699607		R>C	B:1082	(25.49, 34.73, 44.31)
22:50699602		H>Q	B:1083	(24.46, 39.51, 42.90)
22:50699604	rs372395330	H>Y	B:1083	(24.46, 39.51, 42.90)
22:50699599	rs568278596	E>D	B:1084	(24.70, 42.47, 46.83)
22:50699596		N>K	B:1085	(21.41, 42.78, 43.24)
22:50699598		N>Y	B:1085	(21.41, 42.78, 43.24)
22:50696730		V>L	B:1086	(19.90, 38.07, 43.85)
22:50696724	rs201816702 COSM3424267 COSM3424268	G>R	B:1088	(18.70, 34.79, 49.65)
22:50696718	rs373525981	L>V	B:1090	(19.25, 32.87, 55.54)
22:50696715		D>N	B:1091	(16.81, 28.46, 56.46)
22:50696712	rs369173418	V>I	B:1092	(15.50, 25.61, 53.89)
22:50696705		T>I	B:1094	(10.41, 20.58, 56.36)
22:50696703	rs148981556	P>S	B:1095	(7.60, 20.65, 59.05)
22:50696694		T>A	B:1098	(9.27, 11.64, 56.75)
22:50695615	rs201667359	V>L	B:1108	(14.48, 31.81, 54.95)
22:50695612		M>V	B:1109	(14.41, 35.29, 52.31)
22:50695608		P>L	B:1110	(16.73, 38.42, 53.81)
22:50695603		M>V	B:1112	(14.99, 43.74, 51.47)
22:50695593	rs200110495	D>V	B:1115	(7.34, 45.57, 46.97)
22:50695594	rs191191851	D>N	B:1115	(7.34, 45.57, 46.97)
22:50695579		M>V	B:1120	(5.81, 52.63, 42.86)
22:50695570		E>K	B:1123	(6.99, 57.09, 47.44)
22:50695558		E>K	B:1127	(15.85, 62.01, 37.83)
22:50695552	rs150223264	R>W	B:1129	(14.73, 56.74, 44.93)
22:50695547		I>M	B:1130	(14.32, 55.99, 38.96)
22:50695548	rs546039180	I>T	B:1130	(14.32, 55.99, 38.96)
22:50695519	rs375893058	G>R	B:1140	(21.22, 41.05, 38.40)
22:50695515		L>P	B:1141	(19.22, 40.56, 34.90)
22:50695384	rs144201280	A>T	B:1146	(25.61, 34.82, 32.85)
22:50695378		G>S	B:1148	(21.78, 30.93, 32.22)
22:50695073		D>E	B:1153	(7.81, 37.31, 36.90)
22:50695063	rs374797423	G>S	B:1157	(6.73, 42.62, 43.17)
22:50695057		L>V	B:1159	(11.71, 44.07, 42.48)
22:50695045	rs148670675	E>K	B:1163	(15.44, 51.85, 55.15)
22:50694627		I>N	B:1169	(15.82, 40.16, 41.90)
22:50694624		L>P	B:1170	(12.26, 38.82, 44.77)
22:50694622		D>N	B:1171	(9.55, 35.25, 42.53)
22:50694616	rs368240751	G>S	B:1173	(9.10, 30.52, 40.44)
22:50694610	rs535912053 COSM3800283 COSM3800284	A>P	B:1175	(12.61, 30.36, 36.93)
22:50694577		V>M	B:1186	(5.69, 33.03, 30.64)
22:50694567	rs112567753	R>Q	B:1189	(-1.57, 40.23, 31.05)
22:50694568	rs149914576	R>W	B:1189	(-1.57, 40.23, 31.05)
22:50694550		E>K	B:1195	(8.56, 37.82, 22.30)
22:50694546		V>D	B:1196	(5.71, 35.34, 24.93)
22:50694528	rs138065172	R>H	B:1202	(10.40, 28.93, 19.64)
22:50694529	rs2230823	R>C	B:1202	(10.40, 28.93, 19.64)
22:50694522	rs371441235	T>M	B:1204	(15.12, 34.92, 24.96)
22:50694519		Q>R	B:1205	(18.04, 35.66, 28.54)
22:50694516		T>M	B:1206	(15.41, 39.41, 25.88)
22:50694305		I>V	B:1209	(15.35, 43.46, 29.11)
22:50694299		S>T	B:1211	(10.05, 43.43, 32.04)
22:50694296		V>M	B:1212	(13.28, 46.11, 33.03)
22:50694290		C>R	B:1214	(7.78, 48.06, 31.60)
22:50694284	rs370098873	M>V	B:1216	(12.51, 52.41, 33.76)
22:50694280		A>V	B:1217	(8.38, 53.17, 32.67)
22:50694278		E>Q	B:1218	(5.40, 51.67, 36.23)
22:50694272		I>L	B:1220	(9.38, 57.47, 34.87)
22:50694259	rs377211551	T>M	B:1224	(0.78, 50.54, 33.74)
22:50694256		L>P	B:1225	(3.53, 51.17, 29.52)
22:50694251	rs200047423	K>E	B:1227	(-2.77, 47.76, 30.22)
22:50694245		S>G	B:1229	(-7.49, 42.71, 28.82)
22:50694242	rs35396905	D>N	B:1230	(-6.45, 39.85, 26.70)
22:50694239	rs148359556	H>Y	B:1231	(-3.38, 36.59, 25.69)
22:50694118	rs375314561	D>N	B:1233	(-5.52, 43.50, 24.44)
22:50694097		K>E	B:1240	(0.17, 51.43, 20.14)
22:50694084	rs2066776	T>M	B:1244	(2.55, 47.06, 13.78)
22:50694078	rs141322209	P>L	B:1246	(5.65, 43.59, 9.01)
22:50694060		R>Q	B:1252	(6.17, 34.47, 7.51)
22:50694061	rs368431064	R>W	B:1252	(6.17, 34.47, 7.51)
22:50694051	COSM1035384 COSM1035386	S>N	B:1255	(0.71, 31.10, 16.15)
22:50693960		A>T	B:1258	(-1.23, 35.25, 16.73)
22:50693957		K>E	B:1259	(-2.05, 34.23, 11.95)
22:50693953		N>S	B:1260	(-5.79, 34.93, 13.42)
22:50693950	rs368005916	Y>C	B:1261	(-5.05, 40.02, 17.87)
22:50693947		M>T	B:1262	(-1.43, 40.75, 14.61)
22:50693939	rs145695654	L>V	B:1265	(-4.61, 44.49, 14.78)
22:50693933	COSM1417054 COSM1417055	E>K	B:1267	(-1.16, 48.96, 9.66)
22:50693927	rs140876255	E>K	B:1269	(2.66, 53.54, 14.14)
22:50693915		F>L	B:1273	(9.21, 55.57, 23.44)
22:50693911		A>V	B:1274	(9.11, 61.37, 24.34)
22:50693899	rs145222937	T>I	B:1278	(5.87, 63.35, 30.47)
22:50693894	rs139620386	A>T	B:1280	(11.63, 62.08, 31.20)
22:50693884		L>P	B:1283	(19.94, 59.44, 28.51)
22:50693794		N>D	B:1286	(17.84, 56.00, 24.35)
22:50693788	rs565620467	L>V	B:1288	(13.12, 52.89, 27.80)
22:50693785		E>K	B:1289	(13.40, 53.81, 22.43)
22:50693778	rs550397425	M>T	B:1291	(14.94, 48.30, 27.20)
22:50693766		D>V	B:1295	(13.71, 42.73, 17.17)
22:50693763		A>V	B:1296	(14.47, 40.46, 20.41)
22:50693764	rs200832605 COSM3390300 COSM3390301	A>T	B:1296	(14.47, 40.46, 20.41)
22:50693748		T>M	B:1301	(21.77, 43.13, 26.73)
22:50693740	rs202172571	E>K	B:1304	(24.14, 45.94, 25.72)
22:50693736	rs367576600	A>V	B:1305	(22.18, 48.28, 29.64)
22:50693733		L>P	B:1306	(24.65, 48.09, 32.80)
22:50693724	rs559897016	P>L	B:1309	(24.91, 56.62, 28.71)
22:50693721		Y>F	B:1310	(20.10, 56.38, 32.94)
22:50693716		E>K	B:1312	(27.80, 58.53, 33.20)
22:50693712		S>F	B:1313	(26.94, 58.03, 37.76)
22:50693713		S>A	B:1313	(26.94, 58.03, 37.76)
22:50693707		H>Y	B:1315	(29.95, 52.87, 36.21)
22:50693678		Q>H	B:1324	(28.71, 29.97, 37.42)
22:50693673	rs139984390	Y>C	B:1326	(21.70, 25.82, 37.20)
22:50693670	rs555010998	D>A	B:1327	(24.11, 22.14, 35.62)
22:50693671		D>Y	B:1327	(24.11, 22.14, 35.62)
22:50693646		R>H	B:1335	(8.96, 13.16, 36.17)
22:50693626		R>C	B:1342	(12.36, 13.38, 46.10)
22:50691877		P>S	B:1353	(23.52, 27.57, 56.30)