Assessment of Structural Intolerance and Durability
General Structure Information 2v53 SPARC crystal structure of a sparc-collagen complex 3.2Å AUTH E.HOHENESTER,T.SASAKI,C.GIUDICI,R.W.FARNDALE,AUTH 2 H.P.BACHINGERTITL STRUCTURAL BASIS OF SEQUENCE-SPECIFIC COLLAGENTITL 2 RECOGNITION BY SPARC.REF PROC.NATL.ACAD.SCI.USA V. 105 18273 2008REFN ISSN 0027-8424PMID 19011090DOI 10.1073/PNAS.0808452105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ffn GSN crystal structure of calcium-free human gelsolin 3.0Å AUTH S.NAG,Q.MA,H.WANG,S.CHUMNARNSILPA,W.L.LEE,AUTH 2 M.LARSSON,B.KANNAN,M.HERNANDEZ-VALLADARES,AUTH 3 L.D.BURTNICK,R.C.ROBINSONTITL CA2+ BINDING BY DOMAIN 2 PLAYS A CRITICAL ROLE INTITL 2 THE ACTIVATION AND STABILIZATION OF GELSOLIN.REF PROC.NATL.ACAD.SCI.USA V. 106 13713 2009REFN ISSN 0027-8424PMID 19666512DOI 10.1073/PNAS.0812374106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2wcy C7 nmr solution structure of factor i-like modules of complement c7. -1.0Å AUTH M.M.PHELAN,C.T.THAI,D.C.SOARES,R.T.OGATA,AUTH 2 P.N.BARLOW,J.BRAMHAMTITL SOLUTION STRUCTURE OF FACTOR I-LIKE MODULES FROMTITL 2 COMPLEMENT C7 REVEALS A PAIR OF FOLLISTATINTITL 3 DOMAINS IN COMPACT PSEUDOSYMMETRIC ARRANGEMENT.REF J.BIOL.CHEM. V. 284 19637 2009REFN ISSN 0021-9258PMID 19419965DOI 10.1074/JBC.M901993200 Variant Set Distributions Ripley’s K […]
General Structure Information 3it8 TNF crystal structure of tnf alpha complexed with a poxvirus mhc-related tnf binding protein 2.8Å AUTH Z.YANG,A.P.WEST JR.,P.J.BJORKMANTITL CRYSTAL STRUCTURE OF TNFA COMPLEXED WITH A POXVIRUSTITL 2 MHC-RELATED TNF BINDING PROTEINREF NAT.STRUCT.MOL.BIOL.REFN ESSN 1545-9985DOI 10.1038/NSMB.1683 Variant Set Distributions Mapped Variants
General Structure Information 3gt8 EGFR crystal structure of the inactive egfr kinase domain in complex with amp-pnp 2.96Å AUTH N.JURA,N.F.ENDRES,K.ENGEL,S.DEINDL,R.DAS,AUTH 2 M.H.LAMERS,D.E.WEMMER,X.ZHANG,J.KURIYANTITL MECHANISM FOR ACTIVATION OF THE EGF RECEPTORTITL 2 CATALYTIC DOMAIN BY THE JUXTAMEMBRANE SEGMENT.REF CELL(CAMBRIDGE,MASS.) V. 137 1293 2009REFN ISSN 0092-8674PMID 19563760DOI 10.1016/J.CELL.2009.04.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3rcd ERBB2 her2 kinase domain complexed with tak-285 3.21Å AUTH T.ISHIKAWA,M.SETO,H.BANNO,Y.KAWAKITA,M.OORUI,T.TANIGUCHI,AUTH 2 Y.OHTA,T.TAMURA,A.NAKAYAMA,H.MIKI,H.KAMIGUCHI,T.TANAKA,AUTH 3 N.HABUKA,S.SOGABE,J.YANO,K.AERTGEERTS,K.KAMIYAMATITL DESIGN AND SYNTHESIS OF NOVEL HUMAN EPIDERMAL GROWTH FACTORTITL 2 RECEPTOR 2 (HER2)/EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR)TITL 3 DUAL INHIBITORS BEARING A PYRROLO[3,2-D]PYRIMIDINE SCAFFOLD.REF J.MED.CHEM. V. 54 8030 2011REFN ISSN 0022-2623PMID 22003817DOI 10.1021/JM2008634 Variant Set Distributions Ripley’s […]
General Structure Information 3kls C5 structure of complement c5 in complex with ssl7 3.6Å AUTH N.S.LAURSEN,N.GORDON,S.HERMANS,N.LORENZ,N.JACKSON,B.WINES,AUTH 2 E.SPILLNER,J.B.CHRISTENSEN,M.JENSEN,F.FREDSLUND,M.BJERRE,AUTH 3 L.SOTTRUP-JENSEN,J.D.FRASER,G.R.ANDERSENTITL STRUCTURAL BASIS FOR INHIBITION OF COMPLEMENT C5 BY THE SSL7TITL 2 PROTEIN FROM STAPHYLOCOCCUS AUREUSREF PROC.NATL.ACAD.SCI.USA V. 107 3681 2010REFN ISSN 0027-8424PMID 20133685DOI 10.1073/PNAS.0910565107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3ghg FGG crystal structure of human fibrinogen 2.9Å AUTH J.M.KOLLMAN,L.PANDI,M.R.SAWAYA,M.RILEY,R.F.DOOLITTLETITL CRYSTAL STRUCTURE OF HUMAN FIBRINOGEN.REF BIOCHEMISTRY V. 48 3877 2009REFN ISSN 0006-2960PMID 19296670DOI 10.1021/BI802205G Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ghg FGB crystal structure of human fibrinogen 2.9Å AUTH J.M.KOLLMAN,L.PANDI,M.R.SAWAYA,M.RILEY,R.F.DOOLITTLETITL CRYSTAL STRUCTURE OF HUMAN FIBRINOGEN.REF BIOCHEMISTRY V. 48 3877 2009REFN ISSN 0006-2960PMID 19296670DOI 10.1021/BI802205G Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ghg FGA crystal structure of human fibrinogen 2.9Å AUTH J.M.KOLLMAN,L.PANDI,M.R.SAWAYA,M.RILEY,R.F.DOOLITTLETITL CRYSTAL STRUCTURE OF HUMAN FIBRINOGEN.REF BIOCHEMISTRY V. 48 3877 2009REFN ISSN 0006-2960PMID 19296670DOI 10.1021/BI802205G Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants