Assessment of Structural Intolerance and Durability
General Structure Information 3kq0 ORM1 crystal structure of human alpha1-acid glycoprotein 1.8Å AUTH D.L.SCHONFELD,R.B.RAVELLI,U.MUELLER,A.SKERRATITL THE 1.8-A CRYSTAL STRUCTURE OF ALPHA1-ACIDTITL 2 GLYCOPROTEIN (OROSOMUCOID) SOLVED BY UV RIP REVEALSTITL 3 THE BROAD DRUG-BINDING ACTIVITY OF THIS HUMANTITL 4 PLASMA LIPOCALIN.REF J.MOL.BIOL. V. 384 393 2008REFN ISSN 0022-2836PMID 18823996DOI 10.1016/J.JMB.2008.09.020 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2w08 APCS the structure of serum amyloid p component bound to 0- phospho-threonine 1.7Å AUTH S.E.KOLSTOE,B.H.RIDHA,V.BELLOTTI,N.WANG,AUTH 2 C.V.ROBINSON,S.J.CRUTCH,G.KEIR,R.KUKKASTENVEHMAS,AUTH 3 J.R.GALLIMORE,W.L.HUTCHINSON,P.N.HAWKINS,S.P.WOOD,AUTH 4 M.N.ROSSOR,M.B.PEPYSTITL MOLECULAR DISSECTION OF ALZHEIMERS DISEASETITL 2 NEUROPATHOLOGY BY DEPLETION OF SERUM AMYLOID PTITL 3 COMPONENT.REF PROC.NATL.ACAD.SCI.USA V. 106 7619 2009REFN ISSN 0027-8424PMID 19372378DOI 10.1073/PNAS.0902640106 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2wnv C1QC complex between c1q globular heads and deoxyribose 1.25Å AUTH V.GARLATTI,A.CHOUQUET,T.LUNARDI,R.VIVES,H.PAIDASSI,AUTH 2 H.LORTAT-JACOB,N.M.THIELENS,G.J.ARLAUD,C.GABORIAUDTITL CUTTING EDGE: C1Q BINDS DEOXYRIBOSE AND HEPARANTITL 2 SULFATE THROUGH NEIGHBORING SITES OF ITSTITL 3 RECOGNITION DOMAIN.REF J.IMMUNOL. V. 185 808 2010REFN ISSN 0022-1767PMID 20548024DOI 10.4049/JIMMUNOL.1000184 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2kl7 EFEMP2 solution nmr structure of the egf-like 1 domain of human fibulin-4. northeast structural genomics target hr6275 -1.0Å AUTH P.ROSSI,Y.CHIANG,S.ANDERSON,G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF THE EGF-LIKE 1 DOMAIN OFTITL 2 HUMAN FIBULIN-4. NORTHEAST STRUCTURAL GENOMICSTITL 3 TARGET HR6275REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ij9 AMY2A directed in situ elongation as a strategy to characterize the covalent glycosyl-enzyme catalytic intermediate of human pancreatic a-amylase 1.85Å AUTH R.ZHANG,C.LI,L.K.WILLIAMS,B.P.REMPEL,G.D.BRAYER,AUTH 2 S.G.WITHERSTITL DIRECTED IN SITU INHIBITOR ELONGATION AS ATITL 2 STRATEGY TO STRUCTURALLY CHARACTERIZE THE COVALENTTITL 3 GLYCOSYL-ENZYME INTERMEDIATE OF HUMAN PANCREATICTITL 4 ALPHA-AMYLASEREF BIOCHEMISTRY V. 48 10752 2009REFN […]
General Structure Information 3bt1 PLAU structure of urokinase receptor, urokinase and vitronectin complex 2.8Å AUTH Q.HUAI,A.ZHOU,L.LIN,A.P.MAZAR,G.C.PARRY,J.CALLAHAN,D.E.SHAW,AUTH 2 B.FURIE,B.C.FURIE,M.HUANGTITL CRYSTAL STRUCTURES OF TWO HUMAN VITRONECTIN, UROKINASE ANDTITL 2 UROKINASE RECEPTOR COMPLEXESREF NAT.STRUCT.MOL.BIOL. V. 15 422 2008REFN ISSN 1545-9993PMID 18376415DOI 10.1038/NSMB.1404 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2v70 SLIT2 third lrr domain of human slit2 3.01Å AUTH C.MORLOT,W.HEMRIKA,R.A.ROMIJN,P.GROS,S.CUSACK,A.A.MCCARTHYTITL PRODUCTION OF SLIT2 LRR DOMAINS IN MAMMALIAN CELLS FORTITL 2 STRUCTURAL STUDIES AND THE STRUCTURE OF HUMAN SLIT2 DOMAINTITL 3 3.REF ACTA CRYSTALLOGR.,SECT.D V. 63 961 2007REFN ISSN 0907-4449PMID 17704564DOI 10.1107/S0907444907035470 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3kq4 CUBN structure of intrinsic factor-cobalamin bound to its receptor cubilin 3.3Å AUTH C.B.ANDERSEN,M.MADSEN,T.STORM,S.K.MOESTRUP,G.R.ANDERSENTITL STRUCTURAL BASIS FOR RECEPTOR RECOGNITION OFTITL 2 VITAMIN-B(12)-INTRINSIC FACTOR COMPLEXES.REF NATURE V. 464 445 2010REFN ISSN 0028-0836PMID 20237569DOI 10.1038/NATURE08874 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3edi TLL1 crystal structure of tolloid-like protease 1 (tll-1) protease domain 1.4Å AUTH A.MAC SWEENEY,S.G.PARRADO,D.VINZENZ,A.BERNARDI,AUTH 2 A.HEIN,U.BODENDORF,P.ERBEL,C.LOGEL,B.GERHARTZTITL STRUCTURAL BASIS FOR THE SUBSTRATE SPECIFICITY OFTITL 2 BONE MORPHOGENETIC PROTEIN 1/TOLLOID-LIKETITL 3 METALLOPROTEASESREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2rjp ADAMTS4 crystal structure of adamts4 with inhibitor bound 2.8Å AUTH L.MOSYAK,K.GEORGIADIS,T.SHANE,K.SVENSON,T.HEBERT,AUTH 2 T.MCDONAGH,S.MACKIE,S.OLLAND,L.LIN,X.ZHONG,R.KRIZ,AUTH 3 E.L.REIFENBERG,L.A.COLLINS-RACIE,C.CORCORAN,AUTH 4 B.FREEMAN,R.ZOLLNER,T.MARVELL,M.VERA,P.E.SUM,AUTH 5 E.R.LAVALLIE,M.STAHL,W.SOMERSTITL CRYSTAL STRUCTURES OF THE TWO MAJOR AGGRECANTITL 2 DEGRADING ENZYMES, ADAMTS4 AND ADAMTS5.REF PROTEIN SCI. V. 17 16 2008REFN ISSN 0961-8368PMID 18042673DOI 10.1110/PS.073287008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]