General Structure Information
| PDB ID | 2rjp |
| HGNC Gene Label(s) | ADAMTS4 |
| Structure Name | crystal structure of adamts4 with inhibitor bound |
| Resolution | 2.8Å |
| Reference | AUTH L.MOSYAK,K.GEORGIADIS,T.SHANE,K.SVENSON,T.HEBERT,AUTH 2 T.MCDONAGH,S.MACKIE,S.OLLAND,L.LIN,X.ZHONG,R.KRIZ,AUTH 3 E.L.REIFENBERG,L.A.COLLINS-RACIE,C.CORCORAN,AUTH 4 B.FREEMAN,R.ZOLLNER,T.MARVELL,M.VERA,P.E.SUM,AUTH 5 E.R.LAVALLIE,M.STAHL,W.SOMERSTITL CRYSTAL STRUCTURES OF THE TWO MAJOR AGGRECANTITL 2 DEGRADING ENZYMES, ADAMTS4 AND ADAMTS5.REF PROTEIN SCI. V. 17 16 2008REFN ISSN 0961-8368PMID 18042673DOI 10.1110/PS.073287008 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 290 |
| Number Of SNVs | 66 |
| Number Of Permutations | 32409 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.117 |
| p-value | 0.006 |
COSMIC
| Number Of Residues | 290 |
| Number Of SNVs | 5 |
| Number Of Permutations | 196 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.1 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 66 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | -0.414 |
| p-value | 0.297 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
