Assessment of Structural Intolerance and Durability
General Structure Information 2k1v INSL5 r3/i5 relaxin chimera -1.0Å AUTH L.M.HAUGAARD-JONSSON,M.A.HOSSAIN,N.L.DALY,AUTH 2 R.A.BATHGATE,J.D.WADE,D.J.CRAIK,K.J.ROSENGRENTITL STRUCTURE OF THE R3/I5 CHIMERIC RELAXIN PEPTIDE, ATITL 2 SELECTIVE GPCR135 AND GPCR142 AGONIST.REF J.BIOL.CHEM. V. 283 23811 2008REFN ISSN 0021-9258PMID 18577524DOI 10.1074/JBC.M800489200 Variant Set Distributions Mapped Variants
General Structure Information 2rjq ADAMTS5 crystal structure of adamts5 with inhibitor bound 2.6Å AUTH L.MOSYAK,K.GEORGIADIS,T.SHANE,K.SVENSON,T.HEBERT,T.MCDONAGH,AUTH 2 S.MACKIE,S.OLLAND,L.LIN,X.ZHONG,R.KRIZ,E.L.REIFENBERG,AUTH 3 L.A.COLLINS-RACIE,C.CORCORAN,B.FREEMAN,R.ZOLLNER,T.MARVELL,AUTH 4 M.VERA,P.E.SUM,E.R.LAVALLIE,M.STAHL,W.SOMERSTITL CRYSTAL STRUCTURES OF THE TWO MAJOR AGGRECAN DEGRADINGTITL 2 ENZYMES, ADAMTS4 AND ADAMTS5.REF PROTEIN SCI. V. 17 16 2008REFN ISSN 0961-8368PMID 18042673DOI 10.1110/PS.073287008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3lgg CECR1 crystal structure of human adenosine deaminase growth factor, adenosine deaminase type 2 (ada2) complexed with transition state analogue, coformycin 2.5Å AUTH A.V.ZAVIALOV,X.YU,D.SPILLMANN,G.LAUVAU,A.V.ZAVIALOVTITL STRUCTURAL BASIS FOR THE GROWTH FACTOR ACTIVITY OF HUMANTITL 2 ADENOSINE DEAMINASE ADA2.REF J.BIOL.CHEM. V. 285 12367 2010REFN ISSN 0021-9258PMID 20147294DOI 10.1074/JBC.M109.083527 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3h5c SERPINA10 x-ray structure of protein z-protein z inhibitor complex 3.26Å AUTH X.HUANG,A.DEMENTIEV,S.T.OLSON,P.G.GETTINSTITL BASIS FOR THE SPECIFICITY AND ACTIVATION OF THE SERPINTITL 2 PROTEIN Z-DEPENDENT PROTEINASE INHIBITOR (ZPI) AS ANTITL 3 INHIBITOR OF MEMBRANE-ASSOCIATED FACTOR XA.REF J.BIOL.CHEM. V. 285 20399 2010REFN ISSN 0021-9258PMID 20427285DOI 10.1074/JBC.M110.112748 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3i3n KLHL11 crystal structure of the btb-back domains of human klhl11 2.6Å AUTH J.W.MURRAY,C.D.O.COOPER,T.KROJER,P.MAHAJAN,E.SALAH,AUTH 2 T.KEATES,P.SAVITSKY,A.C.W.PIKE,A.ROOS,J.MUNIZ,AUTH 3 F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,AUTH 4 A.EDWARDS,S.KNAPP,A.BULLOCK,AUTH 5 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE BTB-BACK DOMAINS OF HUMANTITL 2 KLHL11REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3f1r FGF20 crystal structure of fgf20 dimer 2.5Å AUTH J.KALININA,S.A.BYRON,H.P.MAKARENKOVA,S.K.OLSEN,AUTH 2 A.V.ELISEENKOVA,W.J.LAROCHELLE,M.DHANABAL,S.BLAIS,AUTH 3 D.M.ORNITZ,L.A.DAY,T.A.NEUBERT,P.M.POLLOCK,AUTH 4 M.MOHAMMADITITL HOMODIMERIZATION CONTROLS THE FIBROBLAST GROWTHTITL 2 FACTOR 9 SUBFAMILYS RECEPTOR BINDING AND HEPARANTITL 3 SULFATE-DEPENDENT DIFFUSION IN THE EXTRACELLULARTITL 4 MATRIXREF MOL.CELL.BIOL. V. 29 4663 2009REFN ISSN 0270-7306PMID 19564416DOI 10.1128/MCB.01780-08 Variant Set Distributions Mapped Variants
General Structure Information 3duh IL23A structure of interleukin-23 2.3Å AUTH P.J.LUPARDUS,K.C.GARCIATITL THE STRUCTURE OF INTERLEUKIN-23 REVEALS THE MOLECULAR BASISTITL 2 OF P40 SUBUNIT SHARING WITH INTERLEUKIN-12.REF J.MOL.BIOL. V. 382 931 2008REFN ISSN 0022-2836PMID 18680750DOI 10.1016/J.JMB.2008.07.051 Variant Set Distributions Mapped Variants
General Structure Information 3w3g TLR8 crystal structure of human tlr8 (unliganded form) 2.3Å AUTH H.TANJI,U.OHTO,T.SHIBATA,K.MIYAKE,T.SHIMIZUTITL STRUCTURAL REORGANIZATION OF THE TOLL-LIKE RECEPTOR 8 DIMERTITL 2 INDUCED BY AGONISTIC LIGANDSREF SCIENCE V. 339 1426 2013REFN ISSN 0036-8075PMID 23520111DOI 10.1126/SCIENCE.1229159 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3dlq IL22 crystal structure of the il-22/il-22r1 complex 1.9Å AUTH L.BLEICHER,P.R.DE MOURA,L.WATANABE,D.COLAU,AUTH 2 L.DUMOUTIER,J.-C.RENAULD,I.POLIKARPOVTITL CRYSTAL STRUCTURE OF THE IL-22/IL-22R1 COMPLEX ANDTITL 2 ITS IMPLICATIONS FOR THE IL-22 SIGNALING MECHANISMREF FEBS LETT. V. 582 2985 2008REFN ISSN 0014-5793PMID 18675809DOI 10.1016/J.FEBSLET.2008.07.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2ra4 CCL13 crystal structure of human monocyte chemoattractant protein 4 (mcp- 4/ccl13) 1.7Å AUTH C.BARINKA,A.PRAHL,J.LUBKOWSKITITL STRUCTURE OF HUMAN MONOCYTE CHEMOATTRACTANT PROTEIN 4TITL 2 (MCP-4/CCL13).REF ACTA CRYSTALLOGR.,SECT.D V. 64 273 2008REFN ISSN 0907-4449PMID 18323622DOI 10.1107/S0907444907066164 Variant Set Distributions Mapped Variants