3KLS.B | C5 – ASTRID

3KLS.B | C5

General Structure Information

PDB ID	3kls
HGNC Gene Label(s)	C5
Structure Name	structure of complement c5 in complex with ssl7
Resolution	3.6Å
Reference	AUTH N.S.LAURSEN,N.GORDON,S.HERMANS,N.LORENZ,N.JACKSON,B.WINES,AUTH 2 E.SPILLNER,J.B.CHRISTENSEN,M.JENSEN,F.FREDSLUND,M.BJERRE,AUTH 3 L.SOTTRUP-JENSEN,J.D.FRASER,G.R.ANDERSENTITL STRUCTURAL BASIS FOR INHIBITION OF COMPLEMENT C5 BY THE SSL7TITL 2 PROTEIN FROM STAPHYLOCOCCUS AUREUSREF PROC.NATL.ACAD.SCI.USA V. 107 3681 2010REFN ISSN 0027-8424PMID 20133685DOI 10.1073/PNAS.0910565107

Variant Set Distributions

ExAC Variants

Number Of Residues	1478
Number Of SNVs	356
Number Of Permutations	92921
Optimal Distance Threshold	13.0
K Statistic	0.023
p-value	0.854

COSMIC

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	356
Number Of COSMIC SNVs	12
Optimal Distance Threshold	52.0
K Statistic	-0.117
p-value	0.531

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:123812460	rs142075999	T>I	B:22	(-19.00, 120.84, 69.07)
9:123812461	rs564964646	T>A	B:22	(-19.00, 120.84, 69.07)
9:123808659	rs113419504	Y>C	B:23	(-17.21, 118.52, 73.02)
9:123808632	rs144876205	R>H	B:32	(-11.43, 94.46, 76.06)
9:123808596	rs569108023	Y>S	B:44	(-16.25, 123.54, 64.33)
9:123808579		F>L	B:50	(-7.85, 123.03, 72.65)
9:123808576		D>H	B:51	(-3.88, 121.18, 75.78)
9:123808536		F>Y	B:64	(-7.27, 104.75, 91.72)
9:123808500		E>G	B:76	(-0.74, 121.41, 63.08)
9:123808480		A>S	B:83	(-4.89, 107.83, 73.28)
9:123805440		Q>P	B:88	(-3.26, 97.65, 83.98)
9:123805438		P>S	B:89	(-4.56, 94.99, 86.87)
9:123805387		V>I	B:106	(-11.67, 114.35, 78.70)
9:123805375	rs143947726	H>N	B:110	(-14.32, 125.20, 76.41)
9:123805360		K>E	B:115	(-19.82, 107.98, 79.94)
9:123805352		M>I	B:117	(-18.49, 103.25, 79.97)
9:123805353		M>T	B:117	(-18.49, 103.25, 79.97)
9:123805348		I>V	B:119	(-15.48, 97.17, 82.12)
9:123805344		T>I	B:120	(-14.76, 93.26, 80.37)
9:123805341		Y>C	B:121	(-12.85, 91.08, 83.77)
9:123805324		F>L	B:127	(-6.47, 80.41, 68.82)
9:123805321		I>V	B:128	(-6.93, 74.88, 71.54)
9:123805317		H>R	B:129	(-2.91, 72.94, 67.05)
9:123805314		T>I	B:130	(-5.26, 69.39, 68.48)
9:123805296	COSM1198867	T>N	B:136	(-7.41, 55.54, 69.26)
9:123805293		P>L	B:137	(-7.35, 53.70, 72.42)
9:123800218	rs17216529	V>I	B:145	(-1.83, 77.37, 72.84)
9:123800211	rs544818019 COSM274293	S>L	B:147	(-1.93, 83.32, 72.63)
9:123800200		D>N	B:151	(-3.03, 94.42, 69.63)
9:123800172		V>A	B:160	(-4.55, 76.79, 82.49)
9:123800159		I>M	B:164	(-13.41, 67.97, 80.02)
9:123797162		G>E	B:168	(-17.89, 66.41, 82.46)
9:123797163		G>R	B:168	(-17.89, 66.41, 82.46)
9:123797160	COSM3926091	S>P	B:169	(-15.39, 65.45, 84.67)
9:123797153	rs185695138	V>A	B:171	(-9.32, 64.25, 83.94)
9:123797149	rs375608449	D>E	B:172	(-5.52, 66.82, 83.79)
9:123797148		M>V	B:173	(-5.26, 70.70, 85.29)
9:123797141		E>G	B:175	(-0.02, 75.71, 84.86)
9:123797126		I>T	B:180	(6.86, 82.96, 71.51)
9:123797093	rs200524363	P>L	B:191	(-6.82, 56.12, 78.27)
9:123797090		S>F	B:192	(-5.82, 51.80, 78.18)
9:123797088		N>D	B:193	(-10.47, 51.43, 78.67)
9:123794465		M>T	B:198	(-16.70, 64.62, 72.51)
9:123794442		K>E	B:206	(-2.29, 81.66, 85.89)
9:123794415		A>T	B:215	(-11.53, 72.50, 72.03)
9:123794406		E>K	B:218	(-14.38, 61.89, 68.90)
9:123794394		Y>H	B:222	(-9.10, 50.06, 65.67)
9:123792742		I>V	B:231	(-22.32, 53.48, 52.73)
9:123792735	rs531284110	P>L	B:233	(-25.43, 58.06, 49.06)
9:123792729		Y>C	B:235	(-28.94, 62.27, 44.90)
9:123792720	rs567288479	I>T	B:238	(-32.56, 64.71, 51.06)
9:123792718	rs369524514	G>S	B:239	(-35.13, 66.70, 48.26)
9:123792699	rs201354178	N>S	B:245	(-36.96, 57.99, 46.54)
9:123792679	rs112959008	A>T	B:252	(-18.97, 44.15, 50.08)
9:123789544	rs530899083	Y>C	B:256	(-9.63, 38.21, 49.90)
9:123789541		N>T	B:257	(-8.98, 40.92, 45.11)
9:123789520		D>G	B:264	(-27.14, 39.43, 56.81)
9:123789518	rs148539497	V>I	B:265	(-27.63, 43.89, 55.45)
9:123789514		Y>C	B:266	(-29.11, 43.69, 59.88)
9:123789502	rs138046070	G>V	B:270	(-31.62, 58.94, 61.59)
9:123789500		I>V	B:271	(-32.91, 62.28, 62.56)
9:123789496	rs369240162	R>K	B:272	(-27.12, 63.96, 63.31)
9:123789485		K>Q	B:276	(-20.98, 69.33, 68.12)
9:123789479	rs375993804	D>N	B:278	(-23.03, 62.66, 70.69)
9:123789468	rs201821112	E>D	B:281	(-33.17, 60.74, 68.27)
9:123789460	rs529999368	Q>P	B:284	(-39.14, 53.32, 64.15)
9:123789455		A>T	B:286	(-35.11, 50.12, 59.91)
9:123789442		T>I	B:290	(-31.35, 43.41, 51.13)
9:123789440		M>V	B:291	(-29.51, 39.17, 51.62)
9:123787855		I>L	B:293	(-26.34, 39.53, 46.64)
9:123787850		N>K	B:294	(-22.02, 39.76, 43.83)
9:123787812		V>A	B:307	(-40.21, 60.67, 60.14)
9:123787813		V>I	B:307	(-40.21, 60.67, 60.14)
9:123787803		L>R	B:310	(-41.23, 57.36, 63.46)
9:123787786		E>K	B:316	(-39.54, 68.22, 54.14)
9:123787772		N>K	B:320	(-33.74, 71.95, 57.19)
9:123787771		K>Q	B:321	(-32.86, 68.57, 60.81)
9:123787753		V>L	B:327	(-24.68, 49.58, 57.46)
9:123787743	rs147430470	I>T	B:330	(-23.38, 39.98, 59.03)
9:123787732	rs570763379	G>R	B:334	(-17.87, 33.14, 58.60)
9:123785759	rs138785909	Y>H	B:347	(-33.50, 65.78, 55.04)
9:123785740	rs145993279	K>R	B:353	(-28.78, 79.21, 50.75)
9:123785738	rs34552775	L>M	B:354	(-31.89, 83.76, 49.82)
9:123785735		N>D	B:355	(-27.76, 86.10, 51.64)
9:123785722	rs372579408	T>N	B:359	(-28.08, 95.53, 52.28)
9:123785705		P>S	B:365	(-35.28, 109.69, 54.08)
9:123783946		Q>H	B:381	(-21.27, 77.13, 45.80)
9:123783933		V>I	B:386	(-31.53, 82.82, 39.85)
9:123783899		V>A	B:397	(-45.85, 109.14, 59.19)
9:123783867		K>Q	B:408	(-38.60, 89.53, 38.86)
9:123783854	COSM607504	R>H	B:412	(-24.03, 90.19, 38.25)
9:123783855	rs148822412	R>G	B:412	(-24.03, 90.19, 38.25)
9:123783816		P>S	B:425	(-42.18, 107.30, 49.98)
9:123783810		G>R	B:427	(-43.02, 109.05, 54.60)
9:123783806		V>A	B:428	(-41.22, 105.90, 54.73)
9:123783788		N>S	B:434	(-40.89, 89.22, 51.57)
9:123782432		P>R	B:443	(-41.44, 73.71, 43.14)
9:123782425		E>D	B:445	(-43.62, 73.78, 48.44)
9:123782423		N>T	B:446	(-39.42, 73.55, 47.32)
9:123782419		Q>H	B:447	(-38.83, 78.38, 45.48)
9:123782418		A>T	B:448	(-36.14, 80.31, 48.37)
9:123782414		R>T	B:449	(-39.51, 81.60, 50.69)
9:123782415	rs2230213	R>G	B:449	(-39.51, 81.60, 50.69)
9:123782408	rs56188613	G>V	B:451	(-36.98, 88.29, 55.55)
9:123782402		R>Q	B:453	(-38.67, 95.00, 60.18)
9:123782396		I>R	B:455	(-36.45, 101.26, 60.43)
9:123782377		S>R	B:461	(-33.27, 118.16, 61.98)
9:123782372		S>I	B:463	(-31.12, 115.50, 59.12)
9:123782347	rs201640401	D>E	B:471	(-15.34, 97.50, 44.29)
9:123782342	rs78640581	H>R	B:473	(-13.75, 93.40, 43.06)
9:123782339		K>M	B:474	(-15.95, 88.91, 47.39)
9:123782336	rs151271738	A>V	B:475	(-12.77, 92.01, 48.24)
9:123782319	rs142376026	H>D	B:481	(-7.03, 103.96, 47.31)
9:123782309		I>T	B:484	(-16.88, 106.77, 50.28)
9:123782292		S>C	B:490	(-32.52, 116.00, 53.47)
9:123782289		P>S	B:491	(-30.63, 118.05, 55.56)
9:123782282		I>T	B:493	(-29.77, 123.66, 55.41)
9:123780124		S>P	B:505	(-10.62, 96.99, 63.20)
9:123780106		H>N	B:511	(-7.81, 104.70, 60.47)
9:123780096	rs199664327	T>M	B:514	(-11.71, 115.97, 58.24)
9:123780087		K>R	B:517	(-19.01, 120.73, 52.19)
9:123780078		D>G	B:520	(-20.48, 123.81, 45.81)
9:123780063		S>N	B:525	(-15.71, 111.92, 47.32)
9:123780057		N>S	B:527	(-10.13, 108.29, 48.82)
9:123780045		T>I	B:531	(-4.78, 99.63, 55.96)
9:123780042		Q>R	B:532	(-2.52, 95.22, 56.64)
9:123780040		N>D	B:533	(-4.25, 98.14, 60.19)
9:123780012		V>A	B:542	(-19.60, 109.52, 58.26)
9:123780001		V>I	B:546	(-26.28, 120.10, 61.88)
9:123779997		T>I	B:547	(-26.34, 124.30, 63.36)
9:123779985	rs189496803	T>I	B:551	(-30.25, 121.83, 69.13)
9:123779983		A>T	B:552	(-26.86, 120.50, 68.06)
9:123779971	rs371730753	S>T	B:556	(-24.27, 109.46, 61.14)
9:123779950	rs368001045	I>V	B:563	(-11.07, 93.43, 53.80)
9:123779947		E>K	B:564	(-7.58, 91.23, 51.46)
9:123779926	rs147226792	L>V	B:571	(3.95, 81.24, 56.32)
9:123779789		V>F	B:573	(5.29, 76.01, 53.57)
9:123779785		H>L	B:574	(6.99, 75.53, 49.67)
9:123779765		A>T	B:581	(4.78, 61.71, 45.02)
9:123779750		Q>K	B:586	(12.43, 60.91, 49.89)
9:123779718		M>I	B:596	(9.02, 90.24, 58.62)
9:123779705		A>T	B:601	(4.17, 75.68, 63.70)
9:123779690		D>N	B:606	(-3.27, 61.01, 58.38)
9:123779685		S>R	B:607	(-4.99, 63.51, 55.75)
9:123779681		V>M	B:609	(-8.66, 62.52, 59.97)
9:123779641	rs530688966	R>T	B:622	(-10.35, 76.98, 61.49)
9:123778658		F>I	B:624	(-9.27, 85.92, 59.94)
9:123778648		L>S	B:627	(-9.69, 86.63, 65.24)
9:123778642		K>T	B:629	(-16.44, 87.49, 66.19)
9:123778637		D>N	B:631	(-16.70, 93.45, 65.54)
9:123778627		C>F	B:634	(-23.72, 95.06, 64.18)
9:123778619		G>R	B:637	(-25.07, 99.40, 58.99)
9:123778600		A>D	B:643	(-26.75, 106.76, 68.41)
9:123778597		N>S	B:644	(-28.28, 103.08, 66.76)
9:123778590	rs543184008	F>L	B:646	(-21.54, 106.65, 66.73)
9:123778587	rs202080772	H>Q	B:647	(-24.54, 101.04, 69.84)
9:123778588		H>L	B:647	(-24.54, 101.04, 69.84)
9:123778540	rs370045659	Q>R	B:663	(-30.96, 102.97, 74.75)
9:123777533		P>R	B:668	(-27.25, 90.57, 72.18)
9:123777528		K>E	B:670	(-26.50, 86.11, 66.23)
9:123777525		E>K	B:671	(-25.74, 85.63, 62.40)
9:123777519	rs369245774 COSM1104721	L>I	B:673	(-22.90, 91.28, 59.21)
9:123777487		I>M	B:683	(-40.20, 43.68, 69.38)
9:123777486	rs144615264	E>K	B:684	(-38.79, 48.43, 67.76)
9:123776343		K>E	B:689	(-42.60, 48.49, 78.93)
9:123776294		V>D	B:705	(-30.05, 36.34, 70.12)
9:123776267		R>Q	B:714	(-31.94, 35.33, 78.83)
9:123776258		R>Q	B:717	(-28.10, 35.79, 84.05)
9:123776239	rs199578595	R>S	B:723	(-37.19, 48.16, 88.43)
9:123776238	rs372960828	C>R	B:724	(-36.79, 45.01, 83.54)
9:123776235		I>L	B:725	(-37.55, 41.01, 84.83)
9:123776231	rs369235335	K>R	B:726	(-42.70, 42.01, 83.15)
9:123776223	rs138577779	T>A	B:729	(-39.60, 37.81, 79.76)
9:123776217	rs551951176	C>R	B:731	(-39.69, 41.24, 74.45)
9:123776208		V>I	B:734	(-42.17, 38.32, 71.17)
9:123776202		S>G	B:736	(-38.62, 33.49, 70.44)
9:123776193		R>C	B:739	(-36.27, 31.84, 66.89)
9:123776184	COSM1459727	I>V	B:742	(-38.99, 34.58, 59.90)
9:123776153		L>Q	B:752	(-32.43, 31.66, 61.74)
9:123770770		K>R	B:755	(-30.49, 40.86, 65.54)
9:123770747		P>S	B:763	(-17.67, 55.40, 69.70)
9:123770743		E>G	B:764	(-17.41, 51.45, 66.52)
9:123770741	rs202230425	I>V	B:765	(-12.95, 53.94, 64.26)
9:123770737	COSM1104720	R>Q	B:766	(-14.30, 49.03, 62.10)
9:123770738		R>W	B:766	(-14.30, 49.03, 62.10)
9:123770734		S>N	B:767	(-9.64, 53.47, 60.75)
9:123770731		Y>C	B:768	(-4.16, 53.85, 63.48)
9:123770701		H>R	B:778	(11.42, 75.88, 63.76)
9:123770692		P>R	B:781	(14.62, 84.20, 59.65)
9:123770687		R>G	B:783	(15.34, 83.16, 53.84)
9:123769208		I>T	B:799	(2.80, 69.41, 56.16)
9:123769205	rs531503832	Q>R	B:800	(-0.71, 71.49, 59.17)
9:123769200	rs17611	V>I	B:802	(0.74, 78.27, 62.36)
9:123769184	rs372326645	T>I	B:807	(1.74, 90.75, 62.44)
9:123768332		I>M	B:809	(-2.70, 84.36, 63.34)
9:123768334		I>V	B:809	(-2.70, 84.36, 63.34)
9:123768331		C>R	B:810	(-0.60, 83.27, 59.34)
9:123768303		V>G	B:819	(4.14, 58.75, 51.06)
9:123768292		V>I	B:823	(4.40, 46.96, 44.37)
9:123768273		I>T	B:829	(3.25, 35.86, 60.45)
9:123768226		V>L	B:845	(0.99, 41.17, 46.37)
9:123768207	COSM1104718	S>F	B:851	(-0.77, 48.60, 35.27)
9:123760038	rs539098188	M>I	B:859	(9.96, 31.27, 51.76)
9:123760030		V>A	B:862	(15.48, 29.11, 58.01)
9:123760031		V>L	B:862	(15.48, 29.11, 58.01)
9:123760024	rs199660150	G>E	B:864	(14.19, 24.70, 61.18)
9:123760016		T>P	B:867	(9.94, 23.70, 53.06)
9:123760005		S>R	B:870	(15.56, 21.63, 48.07)
9:123760006	rs532367358	S>T	B:870	(15.56, 21.63, 48.07)
9:123759967		C>S	B:883	(10.48, 31.61, 40.53)
9:123759961	rs56040400	R>H	B:885	(7.58, 34.48, 36.68)
9:123759940		S>F	B:892	(-5.05, 44.79, 42.68)
9:123759929	rs370940275	V>L	B:896	(0.66, 34.72, 48.64)
9:123759922		F>Y	B:898	(4.56, 30.52, 51.28)
9:123759901	rs545046042	I>T	B:905	(11.37, 25.34, 69.91)
9:123759896		L>F	B:907	(13.55, 29.29, 65.10)
9:123759893		H>Y	B:908	(12.99, 32.96, 65.58)
9:123759889		N>S	B:909	(14.22, 34.32, 60.13)
9:123759874		L>P	B:914	(9.00, 40.53, 45.33)
9:123759844		V>G	B:924	(12.36, 40.05, 57.18)
9:123759832	rs41309892	R>Q	B:928	(6.50, 34.47, 67.55)
9:123758571	rs41309902	G>V	B:933	(1.90, 23.13, 78.65)
9:123758572		G>C	B:933	(1.90, 23.13, 78.65)
9:123758553		Y>S	B:939	(10.04, 25.93, 94.91)
9:123758554		Y>H	B:939	(10.04, 25.93, 94.91)
9:123758533		P>T	B:946	(26.35, 38.10, 105.09)
9:123758530		R>G	B:947	(27.42, 41.30, 108.41)
9:123758523		I>T	B:949	(21.18, 40.44, 110.22)
9:123758524		I>V	B:949	(21.18, 40.44, 110.22)
9:123753556		T>P	B:952	(21.43, 32.58, 109.68)
9:123753552		I>T	B:953	(25.38, 32.55, 107.96)
9:123753553		I>V	B:953	(25.38, 32.55, 107.96)
9:123753543	COSM171472	R>Q	B:956	(26.57, 27.79, 99.24)
9:123753540		K>M	B:957	(20.41, 27.95, 97.91)
9:123753528		Y>C	B:961	(18.74, 20.21, 86.18)
9:123753522		I>T	B:963	(13.72, 16.76, 85.30)
9:123753516	rs375555428	L>S	B:965	(8.80, 12.39, 85.10)
9:123753514	rs75268750	D>Y	B:966	(5.03, 15.36, 83.22)
9:123753504		P>R	B:969	(9.61, 15.75, 74.81)
9:123753478		S>C	B:978	(16.99, 37.88, 90.26)
9:123752050		V>I	B:984	(13.07, 47.24, 98.20)
9:123752032		A>T	B:990	(10.42, 46.90, 88.19)
9:123752013		G>D	B:996	(5.90, 51.91, 81.71)
9:123752007		N>T	B:998	(3.60, 46.60, 84.54)
9:123751999		T>S	B:1001	(1.07, 39.29, 87.59)
9:123751986		K>R	B:1005	(-5.66, 44.83, 82.53)
9:123751971	rs34362143	A>V	B:1010	(-5.94, 46.35, 87.11)
9:123751957		V>I	B:1015	(-0.25, 53.03, 90.43)
9:123751950		P>L	B:1017	(4.58, 49.43, 91.68)
9:123751941		Y>C	B:1020	(4.03, 51.27, 97.55)
9:123751932		H>R	B:1023	(6.92, 56.09, 100.11)
9:123751913		N>K	B:1029	(16.92, 60.19, 101.24)
9:123751914	rs201144249	N>S	B:1029	(16.92, 60.19, 101.24)
9:123751902	rs41311881	I>T	B:1033	(20.22, 54.94, 93.70)
9:123751897		H>D	B:1035	(24.78, 56.09, 88.98)
9:123751894		S>P	B:1036	(21.79, 59.84, 86.95)
9:123751891	rs41311883	D>N	B:1037	(19.70, 63.77, 87.10)
9:123751882		I>V	B:1040	(14.85, 64.00, 85.53)
9:123751872		Q>R	B:1043	(10.00, 64.69, 87.20)
9:123751396		M>R	B:1053	(-4.08, 57.63, 88.99)
9:123751397	rs17609	M>L	B:1053	(-4.08, 57.63, 88.99)
9:123751390		S>I	B:1055	(-6.00, 54.53, 84.03)
9:123751388		I>V	B:1056	(-8.79, 54.70, 87.25)
9:123751355	rs377417930	S>R	B:1067	(-16.99, 50.54, 89.38)
9:123751342		G>D	B:1071	(-20.73, 50.21, 83.95)
9:123751327		T>I	B:1076	(-18.48, 49.47, 98.19)
9:123745084		A>V	B:1080	(-12.28, 51.90, 98.75)
9:123745060		Q>R	B:1088	(-1.60, 55.23, 99.01)
9:123745046	rs371131390 COSM3653762	V>I	B:1093	(0.31, 63.21, 92.91)
9:123745025		I>V	B:1100	(-11.48, 62.16, 97.19)
9:123744979		N>S	B:1115	(-23.82, 48.61, 112.53)
9:123744977		G>R	B:1116	(-21.16, 50.71, 111.01)
9:123744967	rs142341763	K>R	B:1119	(-24.48, 48.20, 102.60)
9:123744950		Q>E	B:1125	(-18.44, 38.04, 95.63)
9:123744944		I>V	B:1127	(-13.36, 37.40, 98.97)
9:123744217		G>S	B:1131	(-18.40, 29.03, 106.16)
9:123744202		E>K	B:1136	(-19.96, 33.72, 104.31)
9:123744198		A>G	B:1137	(-22.17, 37.05, 106.28)
9:123744195		R>Q	B:1138	(-20.81, 37.54, 111.99)
9:123744196	rs184484615	R>G	B:1138	(-20.81, 37.54, 111.99)
9:123744186		S>N	B:1141	(-19.24, 42.21, 107.00)
9:123744177		L>H	B:1144	(-16.51, 45.33, 103.31)
9:123744174		T>I	B:1145	(-16.22, 47.12, 107.40)
9:123744145	rs200624729	A>T	B:1155	(-7.70, 59.09, 102.26)
9:123744139		D>Y	B:1157	(-5.67, 63.31, 105.66)
9:123742529		I>V	B:1164	(-15.98, 61.25, 107.15)
9:123742520		A>T	B:1167	(-18.12, 57.23, 110.24)
9:123742502		N>H	B:1173	(-16.99, 51.26, 117.20)
9:123742499	COSM1104712	F>L	B:1174	(-18.74, 46.26, 113.47)
9:123742490		E>Q	B:1177	(-18.49, 46.16, 119.45)
9:123742486	rs367889830	N>S	B:1178	(-18.19, 42.35, 115.77)
9:123742483		T>R	B:1179	(-13.33, 40.94, 115.69)
9:123742484		T>A	B:1179	(-13.33, 40.94, 115.69)
9:123742478	rs373730400	P>S	B:1181	(-14.94, 36.32, 118.56)
9:123742475		A>S	B:1182	(-12.10, 34.84, 115.75)
9:123742466		T>A	B:1185	(-6.43, 34.57, 110.52)
9:123742433		S>T	B:1196	(-3.57, 50.08, 112.99)
9:123742430		L>M	B:1197	(-4.86, 52.56, 110.34)
9:123742402		R>H	B:1206	(-3.68, 47.17, 123.51)
9:123742397	rs371301396	I>V	B:1208	(-7.85, 42.28, 118.32)
9:123742388	COSM3903672	A>T	B:1211	(-5.40, 37.33, 118.77)
9:123742378	rs150470491	R>K	B:1214	(-3.41, 34.00, 120.52)
9:123739174		P>L	B:1223	(11.99, 32.57, 115.62)
9:123739168		Y>C	B:1225	(11.63, 31.73, 108.20)
9:123739165		R>H	B:1226	(6.75, 35.07, 112.69)
9:123739166	rs537101618 COSM3322688	R>C	B:1226	(6.75, 35.07, 112.69)
9:123739160	COSM1459722	W>R	B:1228	(0.62, 35.39, 110.68)
9:123739135	rs148342393	D>A	B:1236	(-5.06, 20.38, 108.70)
9:123739118		T>A	B:1242	(2.90, 25.89, 99.51)
9:123739111	COSM1674764	T>M	B:1244	(-1.14, 31.51, 99.30)
9:123739105	rs142569129	R>H	B:1246	(-6.70, 34.38, 101.35)
9:123739106	rs143353740	R>C	B:1246	(-6.70, 34.38, 101.35)
9:123739101		M>I	B:1247	(-0.79, 32.53, 103.12)
9:123739100		V>I	B:1248	(1.04, 36.62, 101.36)
9:123739072	rs141704823	T>S	B:1257	(-0.57, 45.67, 112.28)
9:123739068		S>R	B:1258	(3.12, 45.12, 113.57)
9:123739070	rs202117985	S>G	B:1258	(3.12, 45.12, 113.57)
9:123739048		N>S	B:1265	(12.47, 42.47, 116.99)
9:123739023		W>C	B:1273	(6.93, 34.29, 104.46)
9:123739010		Q>K	B:1278	(7.00, 38.13, 97.02)
9:123739001		G>R	B:1281	(9.56, 41.27, 90.21)
9:123738995		G>S	B:1283	(4.04, 39.32, 94.34)
9:123738989		Y>H	B:1285	(1.48, 34.16, 95.63)
9:123738986		S>A	B:1286	(-2.64, 38.00, 93.17)
9:123738982	rs200162943	T>I	B:1287	(-3.66, 41.45, 93.50)
9:123737188		G>S	B:1296	(5.67, 46.44, 103.76)
9:123737182		T>S	B:1298	(8.37, 49.51, 101.50)
9:123737163		V>G	B:1304	(14.54, 49.21, 109.54)
9:123737154	rs566156443	L>P	B:1307	(22.05, 47.31, 105.62)
9:123737151	rs548333233	R>H	B:1308	(27.89, 49.51, 102.81)
9:123737152	rs141543606	R>C	B:1308	(27.89, 49.51, 102.81)
9:123737145	rs17610	S>N	B:1310	(29.52, 44.77, 100.20)
9:123737140		D>N	B:1312	(31.77, 39.37, 96.12)
9:123737134		D>N	B:1314	(29.54, 33.25, 92.59)
9:123737112	rs149947699	G>D	B:1321	(32.03, 26.30, 84.90)
9:123737110		A>T	B:1322	(32.22, 29.55, 86.05)
9:123737097	rs532717660	Y>C	B:1326	(27.52, 40.13, 90.79)
9:123737081	rs374922787	K>N	B:1331	(27.34, 52.39, 93.31)
9:123737066		R>S	B:1336	(23.43, 40.82, 84.87)
9:123737058	rs569871287	E>G	B:1339	(18.28, 33.08, 80.80)
9:123734260		N>S	B:1343	(21.99, 20.97, 81.69)
9:123734258	rs201808997	D>N	B:1344	(24.67, 21.84, 86.27)
9:123734249		I>V	B:1347	(26.04, 27.48, 93.38)
9:123734243		S>R	B:1349	(28.12, 32.14, 96.65)
9:123732529		V>I	B:1361	(15.43, 31.19, 90.58)
9:123732517	rs62640868	V>F	B:1365	(8.59, 23.79, 82.55)
9:123732505	rs370948021	S>G	B:1369	(0.15, 16.58, 81.96)
9:123732483		S>N	B:1376	(-10.47, 23.76, 92.13)
9:123732477	rs542114357	Y>F	B:1378	(-15.89, 19.64, 89.23)
9:123732466		D>N	B:1382	(-16.77, 20.26, 73.51)
9:123732454		I>V	B:1386	(-24.84, 22.80, 65.81)
9:123731358	rs145968939	R>C	B:1401	(-20.70, 26.29, 69.45)
9:123731354	rs371503868 COSM1104706	I>T	B:1402	(-15.97, 26.46, 71.75)
9:123731355	rs142459293	I>V	B:1402	(-15.97, 26.46, 71.75)
9:123731346		C>R	B:1405	(-18.06, 24.42, 81.07)
9:123731340		S>R	B:1407	(-18.14, 23.93, 88.76)
9:123725990	rs148636828	S>L	B:1416	(-23.14, 26.60, 98.54)
9:123725976		H>D	B:1421	(-13.18, 37.95, 90.41)
9:123725972	COSM3375055	A>V	B:1422	(-13.40, 34.52, 88.23)
9:123725952		P>S	B:1429	(-6.32, 26.38, 68.61)
9:123725948		T>I	B:1430	(-2.66, 27.08, 65.90)
9:123725940		S>R	B:1433	(-10.36, 32.94, 65.07)
9:123725926	rs17612	E>D	B:1437	(-19.16, 39.66, 67.26)
9:123725916	rs143886761	A>S	B:1441	(-23.18, 38.71, 73.60)
9:123725241		V>E	B:1443	(-20.60, 40.90, 78.30)
9:123725242		V>L	B:1443	(-20.60, 40.90, 78.30)
9:123725218		T>P	B:1451	(-18.20, 40.78, 83.28)
9:123725201		K>N	B:1456	(-3.96, 39.34, 75.02)
9:123725184		L>P	B:1462	(-14.14, 35.20, 80.02)
9:123725038	rs368329850	F>C	B:1472	(-21.34, 22.92, 85.15)
9:123725020		R>Q	B:1478	(-19.92, 31.41, 66.53)
9:123725021	rs138933092	R>W	B:1478	(-19.92, 31.41, 66.53)
9:123724999	rs55649448	V>A	B:1485	(-3.59, 23.64, 60.93)
9:123724979		T>A	B:1492	(-5.34, 25.16, 77.21)
9:123724974		F>L	B:1493	(-10.75, 25.53, 79.91)
9:123724964	rs376245744	E>K	B:1497	(-10.67, 32.32, 92.52)
9:123723825		F>S	B:1508	(-4.22, 19.81, 77.49)
9:123723810		N>S	B:1513	(-12.42, 15.15, 65.80)
9:123723777	rs373918312	A>V	B:1524	(5.18, 17.15, 54.64)
9:123723778	rs150280452	A>T	B:1524	(5.18, 17.15, 54.64)
9:123723769		C>R	B:1527	(10.25, 16.62, 57.48)
9:123723762	rs542182447	E>A	B:1529	(7.66, 9.92, 60.50)
9:123723760		A>T	B:1530	(11.64, 12.72, 59.61)

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:123805432	COSM1624492	Q>K	B:91	(-10.01, 95.79, 92.62)
9:123800211	COSM274293	S>L	B:147	(-1.93, 83.32, 72.63)
9:123785747	COSM3716120	P>S	B:351	(-32.12, 74.11, 46.40)
9:123782403	COSM3664052	R>G	B:453	(-38.67, 95.00, 60.18)
9:123780128	COSM1674767	I>M	B:503	(-12.07, 103.60, 60.27)
9:123780009	COSM752827	Y>C	B:543	(-18.99, 112.81, 62.38)
9:123779774	COSM1755903	D>H	B:578	(6.85, 70.24, 44.30)
9:123769200	COSM4407021	V>I	B:802	(0.74, 78.27, 62.36)
9:123744991	COSM3664051	Y>C	B:1111	(-23.59, 51.97, 100.35)
9:123744984	COSM1624489	L>F	B:1113	(-25.28, 49.27, 108.05)
9:123744180	COSM1624488	Y>C	B:1143	(-12.95, 41.71, 103.40)
9:123742403	COSM1198864	R>C	B:1206	(-3.68, 47.17, 123.51)
9:123739087	COSM1459721	A>V	B:1252	(0.65, 41.42, 105.46)
9:123725972	COSM3375055	A>V	B:1422	(-13.40, 34.52, 88.23)
9:123725021	COSM274291	R>W	B:1478	(-19.92, 31.41, 66.53)

3KLS.B | C5.

3KLS.B | C5

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants