Assessment of Structural Intolerance and Durability
General Structure Information 3smp PANK1 monoclinic crystal structure of human pantothenate kinase 1 alpha 1.9Å AUTH X.GUAN,W.TEMPEL,B.HONG,A.K.WERNIMONT,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL MONOCLINIC CRYSTAL STRUCTURE OF HUMAN PANTOTHENATE KINASE 1TITL 2 ALPHAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1h3i SETD7 crystal structure of the histone methyltransferase set7/9 2.1Å AUTH J.R.WILSON,C.JING,P.A.WALKER,S.R.MARTIN,S.A.HOWELL,AUTH 2 G.M.BLACKBURN,S.J.GAMBLIN,B.XIAOTITL CRYSTAL STRUCTURE AND FUNCTIONAL ANALYSIS OF THETITL 2 HISTONE METHYLTRANSFERASE SET7/9REF CELL(CAMBRIDGE,MASS.) V. 111 105 2002REFN ISSN 0092-8674PMID 12372304DOI 10.1016/S0092-8674(02)00964-9 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vsv RHPN2 crystal structure of the pdz domain of human rhophilin-2 1.82Å AUTH A.C.W.PIKE,G.KOCHAN,Z.SUN,N.SHAFQAT,E.S.PILKA,AUTH 2 A.ROOS,J.ELKINS,N.BURGESS-BROWN,J.W.MURRAY,AUTH 3 F.VON DELFT,M.WIKSTROM,A.EDWARDS,C.H.ARROWSMITH,AUTH 4 C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMANTITL 2 RHOPHILIN-2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1z9m CADM3 crystal structure of nectin-like molecule-1 protein domain 1 2.4Å AUTH X.DONG,F.XU,Y.GONG,J.GAO,P.LIN,T.CHEN,Y.PENG,AUTH 2 B.QIANG,J.YUAN,X.PENG,Z.RAOTITL CRYSTAL STRUCTURE OF THE V DOMAIN OF HUMANTITL 2 NECTIN-LIKE MOLECULE-1/SYNCAM3/TSLL1/IGSF4B, ATITL 3 NEURAL TISSUE-SPECIFIC IMMUNOGLOBULIN-LIKETITL 4 CELL-CELL ADHESION MOLECULEREF J.BIOL.CHEM. V. 281 10610 2006REFN ISSN 0021-9258PMID 16467305DOI 10.1074/JBC.M513459200 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3b76 LNX1 crystal structure of the third pdz domain of human ligand-of-numb protein-x (lnx1) in complex with the c-terminal peptide from the coxsackievirus and adenovirus receptor 1.75Å AUTH E.UGOCHUKWU,N.BURGESS-BROWN,G.BERRIDGE,J.ELKINS,G.BUNKOCZI,AUTH 2 A.C.W.PIKE,M.SUNDSTROM,C.H.ARROWSMITH,J.WEIGELT,A.M.EDWARDS,AUTH 3 O.GILEADI,F.VON DELFT,D.DOYLETITL CRYSTAL STRUCTURE OF THE THIRD PDZ DOMAIN OF HUMANTITL 2 LIGAND-OF-NUMB PROTEIN-X (LNX1) IN COMPLEX WITH THETITL 3 […]
General Structure Information 2ma2 RASGRP2 solution structure of rasgrp2 ef hands bound to calcium -1.0Å AUTH J.S.IWIG,Y.VERCOULEN,R.DAS,T.BARROS,A.LIMNANDER,Y.CHE,AUTH 2 J.G.PELTON,D.E.WEMMER,J.P.ROOSE,J.KURIYANTITL STRUCTURAL ANALYSIS OF AUTOINHIBITION IN THE RAS-SPECIFICTITL 2 EXCHANGE FACTOR RASGRP1.REF ELIFE V. 2 00813 2013REFN ESSN 2050-084XPMID 23908768DOI 10.7554/ELIFE.00813 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ihj GPT2 human alanine aminotransferase 2 in complex with plp 2.3Å AUTH M.WISNIEWSKA,M.I.SIPONEN,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTENYOVA,A.KOTZSCH,M.MOCHE,T.K.NIELSEN,P.NORDLUND,AUTH 5 T.NYMAN,C.PERSSON,A.K.ROOS,P.SCHUTZ,L.SVENSSON,A.G.THORSELL,AUTH 6 L.TRESAUGUES,S.VAN DEN BERG,J.WEIGELT,M.WELIN,H.SCHULERTITL HUMAN GLUTAMATE PYRUVATE TRANSAMINASE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2kom PARD3 solution structure of humar par-3b pdz2 (residues 451-549) -1.0Å AUTH D.R.JENSEN,C.WOYTOVICH,M.LI,P.DUVNJAK,M.S.CASSIDY,AUTH 2 R.O.FREDERICK,L.F.BERGEMAN,F.C.PETERSON,B.F.VOLKMANTITL RAPID, ROBOTIC, SMALL-SCALE PROTEIN PRODUCTION FORTITL 2 NMR SCREENING AND STRUCTURE DETERMINATION.REF PROTEIN SCI. V. 19 570 2010REFN ISSN 0961-8368PMID 20073081DOI 10.1002/PRO.335 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2x5y ZC3HAV1 human zc3hav1 (artd13), c-terminal domain 1.05Å AUTH T.KARLBERG,M.KLEPSCH,A.THORSELL,C.D.ANDERSSON,A.LINUSSON,AUTH 2 H.SCHULERTITL STRUCTURAL BASIS FOR LACK OF ADP-RIBOSYLTRANSFERASETITL 2 ACTIVITY IN POLY(ADP-RIBOSE) POLYMERASE-13/ZINC FINGERTITL 3 ANTIVIRAL PROTEIN.REF J.BIOL.CHEM. V. 290 7336 2015REFN ISSN 0021-9258PMID 25635049DOI 10.1074/JBC.M114.630160 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2cry KIRREL3 solution structure of the fifth ig-like domain of human kin of irre like 3 -1.0Å AUTH C.KUROSAKI,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIFTH IG-LIKE DOMAIN OFTITL 2 HUMAN KIN OF IRRE LIKE 3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants