Assessment of Structural Intolerance and Durability
General Structure Information 2oci BPHL crystal structure of valacyclovir hydrolase complexed with a product analogue 1.9Å AUTH L.LAI,Z.XU,J.ZHOU,K.D.LEE,G.L.AMIDONTITL MOLECULAR BASIS OF PRODRUG ACTIVATION BY HUMANTITL 2 VALACYCLOVIRASE, AN ALPHA-AMINO ACID ESTERTITL 3 HYDROLASE.REF J.BIOL.CHEM. V. 283 9318 2008REFN ISSN 0021-9258PMID 18256025DOI 10.1074/JBC.M709530200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3czv CA13 crystal structure of the human carbonic anhydrase xiii in complex with acetazolamide 2.0Å AUTH A.DI FIORE,S.M.MONTI,M.HILVO,S.PARKKILA,V.ROMANO,A.SCALONI,AUTH 2 C.PEDONE,A.SCOZZAFAVA,C.T.SUPURAN,G.DE SIMONETITL CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE XIII AND ITSTITL 2 COMPLEX WITH THE INHIBITOR ACETAZOLAMIDE.REF PROTEINS V. 74 164 2008REFN ISSN 0887-3585PMID 18618712DOI 10.1002/PROT.22144 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1r03 FTMT crystal structure of a human mitochondrial ferritin 1.7Å AUTH B.LANGLOIS DESTAINTOT,P.SANTAMBROGIO,T.GRANIER,B.GALLOIS,AUTH 2 J.M.CHEVALLIER,G.PRECIGOUX,S.LEVI,P.AROSIOTITL CRYSTAL STRUCTURE AND BIOCHEMICAL PROPERTIES OF THE HUMANTITL 2 MITOCHONDRIAL FERRITIN AND ITS MUTANT SER144ALAREF J.MOL.BIOL. V. 340 277 2004REFN ISSN 0022-2836PMID 15201052DOI 10.1016/J.JMB.2004.04.036 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2css RIMS1 solution structure of the pdz domain of human kiaa0340 protein -1.0Å AUTH K.INOUE,X.-R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PDZ DOMAIN OF HUMANTITL 2 KIAA0340 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2dip ZSWIM2 solution structure of the zz domain of zinc finger swim domain containing protein 2 -1.0Å AUTH W.DANG,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TERADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZZ DOMAIN OF ZINC FINGERTITL 2 SWIM DOMAIN CONTAINING PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3k2i ACOT4 human acyl-coenzyme a thioesterase 4 2.4Å AUTH M.I.SIPONEN,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 A.KALLAS,T.KARLBERG,P.KRAULIS,T.KOTENYOVA,AUTH 5 A.KOTZSCH,N.MARKOVA,T.K.NIELSEN,P.NORDLUND,T.NYMAN,AUTH 6 C.PERSSON,A.K.ROOS,P.SCHUTZ,L.SVENSSON,AUTH 7 A.G.THORSELL,L.TRESAUGUES,S.VAN DEN BERG,AUTH 8 E.WAHLBERG,J.WEIGELT,M.WELIN,M.WISNIEWSKA,H.SCHULERTITL HUMAN ACYL-COENZYME A THIOESTERASE 4REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2crr SMAP1 solution structure of arfgap domain from human smap1 -1.0Å AUTH T.SUETAKE,M.SATO,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF ARFGAP DOMAIN FROM HUMANTITL 2 SMAP1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3iu6 PBRM1 crystal structure of the sixth bromodomain of human poly-bromodomain containing protein 1 (pb1) 1.79Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2dm8 INADL solution structure of the eighth pdz domain of human inad- like protein -1.0Å AUTH K.INOUE,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE EIGHTH PDZ DOMAIN OFTITL 2 HUMAN INAD-LIKE PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ysm KMT2C solution structure of the first and second phd domain from myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog -1.0Å AUTH X.R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST AND SECOND PHDTITL 2 DOMAIN FROM MYELOID/LYMPHOID OR MIXED-LINEAGETITL 3 LEUKEMIA PROTEIN 3 HOMOLOGREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant […]