General Structure Information
| PDB ID | 2oci |
| HGNC Gene Label(s) | BPHL |
| Structure Name | crystal structure of valacyclovir hydrolase complexed with a product analogue |
| Resolution | 1.9Å |
| Reference | AUTH L.LAI,Z.XU,J.ZHOU,K.D.LEE,G.L.AMIDONTITL MOLECULAR BASIS OF PRODRUG ACTIVATION BY HUMANTITL 2 VALACYCLOVIRASE, AN ALPHA-AMINO ACID ESTERTITL 3 HYDROLASE.REF J.BIOL.CHEM. V. 283 9318 2008REFN ISSN 0021-9258PMID 18256025DOI 10.1074/JBC.M709530200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 254 |
| Number Of SNVs | 71 |
| Number Of Permutations | 21049 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.165 |
| p-value | 0.343 |
COSMIC
| Number Of Residues | 254 |
| Number Of SNVs | 3 |
| Number Of Permutations | 18 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.333 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 71 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | -0.192 |
| p-value | 0.786 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
