Assessment of Structural Intolerance and Durability
General Structure Information 3u1k PNPT1 crystal structure of human pnpase 2.13Å AUTH C.L.LIN,Y.-T.WANG,W.-Z.YANG,Y.-Y.HSIAO,H.S.YUANTITL CRYSTAL STRUCTURE OF HUMAN POLYNUCLEOTIDE PHOSPHORYLASE:TITL 2 INSIGHTS INTO ITS DOMAIN FUNCTION IN RNA BINDING ANDTITL 3 DEGRADATIONREF NUCLEIC ACIDS RES. V. 40 4146 2012REFN ISSN 0305-1048PMID 22210891DOI 10.1093/NAR/GKR1281 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3s4e DUSP19 crystal structrue of a novel mitogen-activated protein kinase phosphatase, skrp1 1.26Å AUTH C.H.WEI,S.Y.RYU,Y.H.JEON,M.Y.YOON,D.G.JEONG,S.J.KIM,S.E.RYUTITL CRYSTAL STRUCTURE OF A NOVEL MITOGEN-ACTIVATED PROTEINTITL 2 KINASE PHOSPHATASE, SKRP1.REF PROTEINS V. 79 3242 2011REFN ISSN 0887-3585PMID 21989941DOI 10.1002/PROT.23156 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1va9 DSCAML1 solution structure of the second fniii domain of dscaml1 protein -1.0Å AUTH X.-R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND FNIII DOMAIN OFTITL 2 DSCAML1 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4if8 SERPINA12 structure of vaspin 2.08Å AUTH J.T.HEIKER,N.KLOTING,P.KOVACS,E.B.KUETTNER,N.STRATER,AUTH 2 S.SCHULTZ,M.KERN,M.STUMVOLL,M.BLUHER,A.G.BECK-SICKINGERTITL VASPIN INHIBITS KALLIKREIN 7 BY SERPIN MECHANISMREF CELL.MOL.LIFE SCI. V. 70 2569 2013REFN ISSN 1420-682XPMID 23370777DOI 10.1007/S00018-013-1258-8 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wt8 MCPH1 structure of the n-terminal brct domain of human microcephalin (mcph1) 1.6Å AUTH M.W.RICHARDS,J.W.C.LEUNG,S.M.ROE,J.CHEN,R.BAYLISSTITL A POCKET ON THE SURFACE OF THE N-TERMINAL BRCTTITL 2 DOMAIN OF MCPH1 IS REQUIRED TO PREVENT ABNORMALTITL 3 CHROMOSOME CONDENSATION.REF J.MOL.BIOL. V. 395 908 2010REFN ISSN 0022-2836PMID 19925808DOI 10.1016/J.JMB.2009.11.029 Variant Set Distributions Pathogenic Proximity Analysis Mapped […]
General Structure Information 4lev MB21D1 structure of human cgas 1.95Å AUTH X.LI,C.SHU,G.YI,C.T.CHATON,C.L.SHELTON,J.DIAO,X.ZUO,C.C.KAO,AUTH 2 A.B.HERR,P.LITITL CYCLIC GMP-AMP SYNTHASE IS ACTIVATED BY DOUBLE-STRANDEDTITL 2 DNA-INDUCED OLIGOMERIZATION.REF IMMUNITY V. 39 1019 2013REFN ISSN 1074-7613PMID 24332030DOI 10.1016/J.IMMUNI.2013.10.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4mwi MLKL crystal structure of the human mlkl pseudokinase domain 1.7Å AUTH J.M.MURPHY,I.S.LUCET,J.M.HILDEBRAND,M.C.TANZER,S.N.YOUNG,AUTH 2 P.SHARMA,G.LESSENE,W.S.ALEXANDER,J.J.BABON,J.SILKE,AUTH 3 P.E.CZABOTARTITL INSIGHTS INTO THE EVOLUTION OF DIVERGENT NUCLEOTIDE-BINDINGTITL 2 MECHANISMS AMONG PSEUDOKINASES REVEALED BY CRYSTALTITL 3 STRUCTURES OF HUMAN AND MOUSE MLKL.REF BIOCHEM.J. V. 457 369 2014REFN ISSN 0264-6021PMID 24219132DOI 10.1042/BJ20131270 Variant Set Distributions Ripley’s K […]
General Structure Information 2cxy ARID1B crystal structure of the hbaf250b at-rich interaction domain (arid) 1.6Å AUTH A.SHIMADA,H.NIWA,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE HBAF250B AT-RICHTITL 2 INTERACTION DOMAIN (ARID)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2b0o ASAP3 crystal structure of uplc1 gap domain 2.06Å AUTH S.ISMAIL,L.SHEN,C.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,AUTH 2 J.WEIGELT,A.BOCHKAREV,H.PARKTITL STRUCTURAL ANALYSIS OF GAP AND ANKYRIN DOMAINS OFTITL 2 UPLC1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4gos VTCN1 crystal structure of human b7-h4 igv-like domain 1.59Å AUTH V.VIGDOROVICH,U.RAMAGOPAL,S.G.NATHENSON,S.C.ALMOTITL CRYSTAL STRUCTURE OF HUMAN B7-H4 IGV-LIKE DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants