General Structure Information
| PDB ID | 2ma2 |
| HGNC Gene Label(s) | RASGRP2 |
| Structure Name | solution structure of rasgrp2 ef hands bound to calcium |
| Resolution | -1.0Å |
| Reference | AUTH J.S.IWIG,Y.VERCOULEN,R.DAS,T.BARROS,A.LIMNANDER,Y.CHE,AUTH 2 J.G.PELTON,D.E.WEMMER,J.P.ROOSE,J.KURIYANTITL STRUCTURAL ANALYSIS OF AUTOINHIBITION IN THE RAS-SPECIFICTITL 2 EXCHANGE FACTOR RASGRP1.REF ELIFE V. 2 00813 2013REFN ESSN 2050-084XPMID 23908768DOI 10.7554/ELIFE.00813 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 81 |
| Number Of SNVs | 13 |
| Number Of Permutations | 1080 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.141 |
| p-value | 0.92 |
COSMIC
| Number Of Residues | 81 |
| Number Of SNVs | 4 |
| Number Of Permutations | 1 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.167 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 13 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.487 |
| p-value | 0.264 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
