General Structure Information
| PDB ID | 3b76 |
| HGNC Gene Label(s) | LNX1 |
| Structure Name | crystal structure of the third pdz domain of human ligand-of-numb protein-x (lnx1) in complex with the c-terminal peptide from the coxsackievirus and adenovirus receptor |
| Resolution | 1.75Å |
| Reference | AUTH E.UGOCHUKWU,N.BURGESS-BROWN,G.BERRIDGE,J.ELKINS,G.BUNKOCZI,AUTH 2 A.C.W.PIKE,M.SUNDSTROM,C.H.ARROWSMITH,J.WEIGELT,A.M.EDWARDS,AUTH 3 O.GILEADI,F.VON DELFT,D.DOYLETITL CRYSTAL STRUCTURE OF THE THIRD PDZ DOMAIN OF HUMANTITL 2 LIGAND-OF-NUMB PROTEIN-X (LNX1) IN COMPLEX WITH THETITL 3 C-TERMINAL PEPTIDE FROM THE COXSACKIEVIRUS AND ADENOVIRUSTITL 4 RECEPTOR.REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 91 |
| Number Of SNVs | 26 |
| Number Of Permutations | 6426 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.129 |
| p-value | 0.429 |
COSMIC
| Number Of Residues | 91 |
| Number Of SNVs | 6 |
| Number Of Permutations | 286 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.133 |
| p-value | 0.372 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 26 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.548 |
| p-value | 0.139 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
