General Structure Information
| PDB ID | 3ihj |
| HGNC Gene Label(s) | GPT2 |
| Structure Name | human alanine aminotransferase 2 in complex with plp |
| Resolution | 2.3Å |
| Reference | AUTH M.WISNIEWSKA,M.I.SIPONEN,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTENYOVA,A.KOTZSCH,M.MOCHE,T.K.NIELSEN,P.NORDLUND,AUTH 5 T.NYMAN,C.PERSSON,A.K.ROOS,P.SCHUTZ,L.SVENSSON,A.G.THORSELL,AUTH 6 L.TRESAUGUES,S.VAN DEN BERG,J.WEIGELT,M.WELIN,H.SCHULERTITL HUMAN GLUTAMATE PYRUVATE TRANSAMINASE 2REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 454 |
| Number Of SNVs | 99 |
| Number Of Permutations | 47014 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.081 |
| p-value | 0.055 |
COSMIC
| Number Of Residues | 454 |
| Number Of SNVs | 3 |
| Number Of Permutations | 24 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.333 |
| p-value | 0.131 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 99 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.306 |
| p-value | 0.128 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
