General Structure Information
| PDB ID | 1h3i |
| HGNC Gene Label(s) | SETD7 |
| Structure Name | crystal structure of the histone methyltransferase set7/9 |
| Resolution | 2.1Å |
| Reference | AUTH J.R.WILSON,C.JING,P.A.WALKER,S.R.MARTIN,S.A.HOWELL,AUTH 2 G.M.BLACKBURN,S.J.GAMBLIN,B.XIAOTITL CRYSTAL STRUCTURE AND FUNCTIONAL ANALYSIS OF THETITL 2 HISTONE METHYLTRANSFERASE SET7/9REF CELL(CAMBRIDGE,MASS.) V. 111 105 2002REFN ISSN 0092-8674PMID 12372304DOI 10.1016/S0092-8674(02)00964-9 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 293 |
| Number Of SNVs | 63 |
| Number Of Permutations | 45383 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.211 |
| p-value | 0.209 |
COSMIC
| Number Of Residues | 293 |
| Number Of SNVs | 6 |
| Number Of Permutations | 550 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.333 |
| p-value | 0.13 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 63 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.086 |
| p-value | 0.201 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
