Assessment of Structural Intolerance and Durability
General Structure Information 4f7o COPS5 crystal structure of csn5 2.6Å AUTH A.ECHALIER,Y.PAN,M.BIROL,N.TAVERNIER,L.PINTARD,F.HOH,C.EBEL,AUTH 2 N.GALOPHE,F.X.CLARET,C.DUMASTITL INSIGHTS INTO THE REGULATION OF THE HUMAN COP9 SIGNALOSOMETITL 2 CATALYTIC SUBUNIT, CSN5/JAB1.REF PROC.NATL.ACAD.SCI.USA V. 110 1273 2013REFN ISSN 0027-8424PMID 23288897DOI 10.1073/PNAS.1209345110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3gvp AHCYL2 human sahh-like domain of human adenosylhomocysteinase 3 2.25Å AUTH M.I.SIPONEN,M.WISNIEWSKA,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 T.KARLBERG,T.KOTENYOVA,L.LEHTIO,M.MOCHE,P.NORDLUND,AUTH 5 T.NYMAN,C.PERSSON,J.SAGEMARK,P.SCHUTZ,A.G.THORSELL,AUTH 6 L.TRESAUGUES,S.VAN DEN BERG,J.WEIGELT,M.WELIN,AUTH 7 H.SCHUELERTITL HUMAN S-ADENOSYL HOMOCYSTEINE HYDROLASE-LIKE 2TITL 2 PROTEIN CRYSTAL STRUCTUREREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3dqv CUL5 structural insights into nedd8 activation of cullin-ring ligases: conformational control of conjugation 3.0Å AUTH D.M.DUDA,L.A.BORG,D.C.SCOTT,H.W.HUNT,M.HAMMEL,AUTH 2 B.A.SCHULMANTITL STRUCTURAL INSIGHTS INTO NEDD8 ACTIVATION OFTITL 2 CULLIN-RING LIGASES: CONFORMATIONAL CONTROL OFTITL 3 CONJUGATION.REF CELL(CAMBRIDGE,MASS.) V. 134 995 2008REFN ISSN 0092-8674PMID 18805092DOI 10.1016/J.CELL.2008.07.022 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1um1 RADIL solution structure of rsgi ruh-007, pdz domain in human cdna -1.0Å AUTH Y.DOI-KATAYAMA,F.HAYASHI,H.HIROTA,S.YOKOYAMATITL SOLUTION STRUCTURE OF RSGI RUH-007, A PDZ DOMAINTITL 2 IN HUMAN CDNAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3zyg NTNG2 netring2 lam and egf1 domains 2.2Å AUTH E.SEIRADAKE,C.H.COLES,P.V.PERESTENKO,K.HARLOS,AUTH 2 R.A.J.MCILHINNEY,A.R.ARICESCU,E.Y.JONESTITL STRUCTURAL BASIS FOR CELL SURFACE PATTERNINGTITL 2 THROUGH NETRING-NGL INTERACTIONS.REF EMBO J. V. 30 4479 2011REFN ISSN 0261-4189PMID 21946559DOI 10.1038/EMBOJ.2011.346 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1siq GCDH the crystal structure and mechanism of human glutaryl-coa dehydrogenase 2.1Å AUTH Z.FU,M.WANG,R.PASCHKE,K.S.RAO,F.E.FRERMAN,J.J.KIMTITL CRYSTAL STRUCTURES OF HUMAN GLUTARYL-COA DEHYDROGENASE WITHTITL 2 AND WITHOUT AN ALTERNATE SUBSTRATE: STRUCTURAL BASES OFTITL 3 DEHYDROGENATION AND DECARBOXYLATION REACTIONSREF BIOCHEMISTRY V. 43 9674 2004REFN ISSN 0006-2960PMID 15274622DOI 10.1021/BI049290C Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4lec METTL21A human methyltransferase-like protein 21a 2.28Å AUTH H.ZENG,A.DONG,H.WUTITL THE CRYSTAL STRUCTURE OF HUMAN METHYLTRANSFERASE-LIKETITL 2 PROTEIN 21A IN COMPLEX WITH SAHREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1xks NUP133 the crystal structure of the n-terminal domain of nup133 reveals a beta-propeller fold common to several nucleoporins 2.35Å AUTH I.C.BERKE,T.BOEHMER,G.BLOBEL,T.U.SCHWARTZTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF NUP133 DOMAINS REVEALSTITL 2 MODULAR BUILDING BLOCKS OF THE NUCLEAR PORE COMPLEX.REF J.CELL BIOL. V. 167 591 2004REFN ISSN 0021-9525PMID 15557116DOI 10.1083/JCB.200408109 Variant Set Distributions […]
General Structure Information 2ovq FBXW7 structure of the skp1-fbw7-cyclinedegc complex 2.6Å AUTH B.HAO,S.OEHLMANN,M.E.SOWA,J.W.HARPER,N.P.PAVLETICHTITL STRUCTURE OF A FBW7-SKP1-CYCLIN E COMPLEX:TITL 2 MULTISITE-PHOSPHORYLATED SUBSTRATE RECOGNITION BY SCFTITL 3 UBIQUITIN LIGASESREF MOL.CELL V. 26 131 2007REFN ISSN 1097-2765PMID 17434132DOI 10.1016/J.MOLCEL.2007.02.022 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2p0k SCMH1 crystal structure of scmh1 1.75Å AUTH N.HERZANYCH,G.SENISTERRA,Y.LIU,L.CROMBET,P.LOPPNAU,AUTH 2 I.KOZIERADZKI,M.VEDADI,J.WEIGELT,M.SUNDSTROM,C.H.ARROWSMITH,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,J.MINTITL STRUCTURE OF SCMH1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants