General Structure Information
| PDB ID | 3dqv |
| HGNC Gene Label(s) | CUL5 |
| Structure Name | structural insights into nedd8 activation of cullin-ring ligases: conformational control of conjugation |
| Resolution | 3.0Å |
| Reference | AUTH D.M.DUDA,L.A.BORG,D.C.SCOTT,H.W.HUNT,M.HAMMEL,AUTH 2 B.A.SCHULMANTITL STRUCTURAL INSIGHTS INTO NEDD8 ACTIVATION OFTITL 2 CULLIN-RING LIGASES: CONFORMATIONAL CONTROL OFTITL 3 CONJUGATION.REF CELL(CAMBRIDGE,MASS.) V. 134 995 2008REFN ISSN 0092-8674PMID 18805092DOI 10.1016/J.CELL.2008.07.022 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 365 |
| Number Of SNVs | 28 |
| Number Of Permutations | 22721 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.09 |
| p-value | 0.059 |
COSMIC
| Number Of Residues | 365 |
| Number Of SNVs | 5 |
| Number Of Permutations | 1134 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.1 |
| p-value | 0.812 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 28 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.087 |
| p-value | 0.768 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
