3ZYG.B | NTNG2

General Structure Information

PDB ID	3zyg
HGNC Gene Label(s)	NTNG2
Structure Name	netring2 lam and egf1 domains
Resolution	2.2Å
Reference	AUTH E.SEIRADAKE,C.H.COLES,P.V.PERESTENKO,K.HARLOS,AUTH 2 R.A.J.MCILHINNEY,A.R.ARICESCU,E.Y.JONESTITL STRUCTURAL BASIS FOR CELL SURFACE PATTERNINGTITL 2 THROUGH NETRING-NGL INTERACTIONS.REF EMBO J. V. 30 4479 2011REFN ISSN 0261-4189PMID 21946559DOI 10.1038/EMBOJ.2011.346

Variant Set Distributions

ExAC Variants

Number Of Residues	317
Number Of SNVs	69
Number Of Permutations	49501
Optimal Distance Threshold	13.0
K Statistic	0.086
p-value	0.016

COSMIC

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	69
Number Of COSMIC SNVs	4
Optimal Distance Threshold	32.0
K Statistic	-0.418
p-value	0.085

Pathogenic Proximity Analysis

COSMIC PathProx Analysis

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:135042342		K>E	B:42	(-9.80, 19.30, 50.49)
9:135042343		K>R	B:42	(-9.80, 19.30, 50.49)
9:135042346		V>G	B:43	(-5.44, 17.79, 48.93)
9:135042352	rs56128215	R>H	B:45	(-3.85, 14.72, 56.50)
9:135042366	rs150719334	V>I	B:50	(-5.80, 4.13, 55.98)
9:135042372		V>M	B:52	(-4.01, -1.00, 58.03)
9:135042387		S>A	B:57	(-0.07, -14.26, 60.64)
9:135042407	COSM1460666	D>E	B:63	(3.26, -13.24, 69.29)
9:135042418		R>K	B:67	(17.59, -11.60, 70.46)
9:135042426	rs137862169	S>A	B:70	(19.63, -2.11, 68.00)
9:135073365		L>V	B:76	(24.94, -7.42, 73.31)
9:135073386		A>T	B:83	(3.12, -7.15, 71.93)
9:135073400		D>E	B:87	(6.95, 0.76, 76.28)
9:135073405		A>V	B:89	(5.41, -2.56, 70.69)
9:135073411	COSM3675262 COSM3675263 COSM3675264	P>L	B:91	(1.98, -1.77, 66.34)
9:135073419		L>F	B:94	(3.35, 3.04, 64.97)
9:135073434	rs186092455	E>Q	B:99	(6.49, 10.99, 64.63)
9:135073444		G>D	B:102	(13.50, 11.93, 68.23)
9:135073475		W>C	B:112	(15.94, -13.20, 56.66)
9:135073480	COSM3375144 COSM3375145 COSM3375146	R>L	B:114	(11.76, -18.57, 60.14)
9:135073489	rs370335313	S>T	B:117	(13.15, -18.66, 54.17)
9:135073490		S>R	B:117	(13.15, -18.66, 54.17)
9:135073492		P>L	B:118	(11.57, -15.88, 52.18)
9:135073500	rs373003373	A>T	B:121	(5.48, -8.49, 53.81)
9:135073527		T>A	B:130	(-11.91, 6.38, 44.20)
9:135073600		S>Y	B:154	(-6.61, -1.52, 43.61)
9:135073611	COSM3952415 COSM3905016 COSM3952416 COSM3905017 COSM3905018 COSM3952417	G>R	B:158	(-9.14, -6.08, 46.07)
9:135073614		R>C	B:159	(-12.88, -8.53, 43.57)
9:135073657		E>G	B:173	(18.95, -10.42, 39.95)
9:135073665	rs531966081	G>S	B:176	(13.49, -8.27, 34.28)
9:135073672		S>F	B:178	(15.17, -2.01, 32.85)
9:135073677		R>C	B:180	(14.29, 2.79, 32.70)
9:135073680		R>W	B:181	(15.09, 8.08, 36.74)
9:135073681		R>P	B:181	(15.09, 8.08, 36.74)
9:135073686	rs145960048	R>G	B:183	(13.25, 12.75, 36.71)
9:135073687		R>H	B:183	(13.25, 12.75, 36.71)
9:135073689		D>N	B:184	(14.00, 8.93, 32.51)
9:135073706		S>R	B:189	(5.50, 6.92, 28.78)
9:135073707		A>T	B:190	(3.78, 8.73, 32.00)
9:135073712		H>Q	B:191	(0.86, 5.39, 31.27)
9:135073741		R>H	B:201	(21.45, 1.54, 44.12)
9:135073767		H>D	B:210	(12.77, 8.59, 52.74)
9:135073768		H>L	B:210	(12.77, 8.59, 52.74)
9:135073770		V>M	B:211	(10.94, 4.55, 49.43)
9:135073786		R>Q	B:216	(6.45, 17.40, 42.01)
9:135073791	COSM304601 COSM752489	R>S	B:218	(5.05, 9.88, 36.45)
9:135073815	COSM1460669	D>N	B:226	(8.56, 24.84, 37.40)
9:135073845		R>W	B:236	(-1.72, 15.31, 27.65)
9:135073846		R>Q	B:236	(-1.72, 15.31, 27.65)
9:135073857		A>T	B:240	(-4.41, 11.49, 27.77)
9:135073882		T>I	B:248	(-6.68, 6.54, 40.18)
9:135073897	rs552481499	R>L	B:253	(-0.62, -5.17, 47.81)
9:135073903	rs189624441	R>Q	B:255	(4.34, -7.75, 46.84)
9:135073912		R>P	B:258	(15.52, -9.51, 49.28)
9:135073921		L>R	B:261	(21.45, -7.20, 52.68)
9:135073930		T>I	B:264	(26.89, -8.01, 52.16)
9:135073944		E>K	B:269	(26.84, -15.38, 61.96)
9:135073950		L>F	B:271	(19.68, -13.92, 61.18)
9:135073962		F>L	B:275	(14.74, -5.82, 61.46)
9:135102243	rs371787820	C>G	B:289	(-15.61, 13.38, 42.18)
9:135102248		N>K	B:290	(-15.97, 12.18, 37.86)
9:135102255	COSM1239646 COSM3847907 COSM3847908	A>T	B:293	(-17.14, 17.71, 43.44)
9:135102259		N>S	B:294	(-16.22, 21.28, 46.04)
9:135102274	rs368147282	R>H	B:299	(-21.29, 11.54, 54.42)
9:135102276	COSM3905031 COSM3905032 COSM3905033	E>K	B:300	(-22.29, 4.36, 55.15)
9:135102283		S>N	B:302	(-16.88, 5.86, 53.95)
9:135102300		E>K	B:308	(-22.96, 19.25, 42.97)
9:135102313	rs540819595	T>I	B:312	(-25.40, 9.98, 42.16)
9:135102315		G>S	B:313	(-22.65, 8.45, 43.93)
9:135102321		D>N	B:315	(-17.18, 8.30, 42.52)
9:135102327	rs147689661	G>S	B:317	(-21.04, 8.31, 38.05)
9:135102348		R>G	B:324	(-31.62, 8.37, 34.69)
9:135102349	rs557724992	R>H	B:324	(-31.62, 8.37, 34.69)
9:135102352		T>I	B:325	(-32.35, 12.99, 29.60)
9:135102354	COSM487157	R>W	B:326	(-27.72, 14.73, 29.09)
9:135102355	COSM1554225 COSM3745866 COSM3745867	R>Q	B:326	(-27.72, 14.73, 29.09)
9:135102363	COSM607920 COSM364138 COSM3699490 COSM3699491	R>W	B:329	(-21.52, 14.16, 30.13)
9:135102364	rs545516472	R>Q	B:329	(-21.52, 14.16, 30.13)

3ZYG.B | NTNG2.

3ZYG.B | NTNG2

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Pathogenic Proximity Analysis

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:135073434	COSM4541198	E>K	B:99	(6.49, 10.99, 64.63)
9:135073824	COSM1756006	N>Y	B:229	(2.73, 24.23, 31.84)
9:135073941	COSM5038020	R>W	B:268	(22.93, -18.51, 58.52)
9:135102255	COSM3847908	A>T	B:293	(-17.14, 17.71, 43.44)
9:135102355	COSM3745867	R>L	B:326	(-27.72, 14.73, 29.09)