General Structure Information
| PDB ID | 3gvp |
| HGNC Gene Label(s) | AHCYL2 |
| Structure Name | human sahh-like domain of human adenosylhomocysteinase 3 |
| Resolution | 2.25Å |
| Reference | AUTH M.I.SIPONEN,M.WISNIEWSKA,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 T.KARLBERG,T.KOTENYOVA,L.LEHTIO,M.MOCHE,P.NORDLUND,AUTH 5 T.NYMAN,C.PERSSON,J.SAGEMARK,P.SCHUTZ,A.G.THORSELL,AUTH 6 L.TRESAUGUES,S.VAN DEN BERG,J.WEIGELT,M.WELIN,AUTH 7 H.SCHUELERTITL HUMAN S-ADENOSYL HOMOCYSTEINE HYDROLASE-LIKE 2TITL 2 PROTEIN CRYSTAL STRUCTUREREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 432 |
| Number Of SNVs | 62 |
| Number Of Permutations | 12415 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.016 |
| p-value | 0.442 |
COSMIC
| Number Of Residues | 432 |
| Number Of SNVs | 3 |
| Number Of Permutations | 7 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.333 |
| p-value | 0.998 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 62 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | -0.169 |
| p-value | 0.853 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
