Assessment of Structural Intolerance and Durability
General Structure Information 1nb9 RFK crystal structure of riboflavin kinase 1.7Å AUTH S.KARTHIKEYAN,Q.ZHOU,F.MSEEH,N.V.GRISHIN,A.L.OSTERMAN,AUTH 2 H.ZHANGTITL CRYSTAL STRUCTURE OF HUMAN RIBOFLAVIN KINASE REVEALS A BETATITL 2 BARREL FOLD AND A NOVEL ACTIVE SITE ARCHREF STRUCTURE V. 11 265 2003REFN ISSN 0969-2126PMID 12623014DOI 10.1016/S0969-2126(03)00024-8 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2wjv UPF1 crystal structure of the complex between human nonsense mediated decay factors upf1 and upf2 2.85Å AUTH M.CLERICI,A.MOURAO,I.GUTSCHE,N.H.GEHRING,M.W.HENTZE,AUTH 2 A.KULOZIK,J.KADLEC,M.SATTLER,S.CUSACKTITL UNUSUAL BIPARTITE MODE OF INTERACTION BETWEEN THETITL 2 NONSENSE-MEDIATED DECAY FACTORS, UPF1 AND UPF2.REF EMBO J. V. 28 2293 2009REFN ISSN 0261-4189PMID 19556969DOI 10.1038/EMBOJ.2009.175 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3f70 L3MBTL2 crystal structure of l3mbtl2-h4k20me1 complex 2.1Å AUTH Y.GUO,N.NADY,C.QI,A.ALLALI-HASSANI,H.ZHU,P.PAN,AUTH 2 M.A.ADAMS-CIOABA,M.F.AMAYA,A.DONG,M.VEDADI,M.SCHAPIRA,AUTH 3 R.J.READ,C.H.ARROWSMITH,J.MINTITL METHYLATION-STATE-SPECIFIC RECOGNITION OF HISTONES BY THETITL 2 MBT REPEAT PROTEIN L3MBTL2.REF NUCLEIC ACIDS RES. V. 37 2204 2009REFN ISSN 0305-1048PMID 19233876DOI 10.1093/NAR/GKP086 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4ddg OTUB1 crystal structure of human otub1/ubch5b~ub/ub 3.3Å AUTH Y.C.JUANG,M.C.LANDRY,M.SANCHES,V.VITTAL,C.C.LEUNG,AUTH 2 D.F.CECCARELLI,A.R.MATEO,J.N.PRUNEDA,D.Y.MAO,R.K.SZILARD,AUTH 3 S.ORLICKY,M.MUNRO,P.S.BRZOVIC,R.E.KLEVIT,F.SICHERI,AUTH 4 D.DUROCHERTITL OTUB1 CO-OPTS LYS48-LINKED UBIQUITIN RECOGNITION TO SUPPRESSTITL 2 E2 ENZYME FUNCTION.REF MOL.CELL V. 45 384 2012REFN ISSN 1097-2765PMID 22325355DOI 10.1016/J.MOLCEL.2012.01.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4bx9 VPS33A human vps33a in complex with a fragment of human vps16 2.6Å AUTH S.C.GRAHAM,L.WARTOSCH,S.R.GRAY,E.J.SCOURFIELD,J.E.DEANE,AUTH 2 J.P.LUZIO,D.J.OWENTITL STRUCTURAL BASIS OF VPS33A RECRUITMENT TO THE HUMAN HOPSTITL 2 COMPLEX BY VPS16.REF PROC.NATL.ACAD.SCI.USA V. 110 13345 2013REFN ISSN 0027-8424PMID 23901104DOI 10.1073/PNAS.1307074110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4akv SNX33 crystal structure of human sorting nexin 33 (snx33) 2.65Å AUTH A.OBERHOLZER,D.S.FROESE,T.KROJER,L.SHRESTHA,AUTH 2 P.FILIPPAKOPOULOS,J.R.C.MUNIZ,F.VON DELFT,C.ARROWSMITH,AUTH 3 J.WEIGELT,A.EDWARDS,C.BOUNTRA,W.W.YUETITL STRUCTURE OF HUMAN SORTING NEXIN 33REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2p82 ATG4A cysteine protease atg4a 2.1Å AUTH J.R.WALKER,T.DAVIS,S.MUJIB,C.BUTLER-COLE,P.J.FINERTY JR.,AUTH 2 J.WEIGELT,M.SUNDSTROM,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 A.BOCHKAREV,S.DHE-PAGANONTITL HUMAN CYSTEINE PROTEASE ATG4AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3s8i DDI1 the retroviral-like protease (rvp) domain of human ddi1 1.7Å AUTH J.R.WALKER,A.ASINAS,A.DONG,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,S.DHE-PAGANON,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL RETROPEPSIN-LIKE DOMAIN OF HUMAN DDI1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1olz SEMA4D the ligand-binding face of the semaphorins revealed by the high resolution crystal structure of sema4d 2.0Å AUTH C.A.LOVE,K.HARLOS,N.MAVADDAT,S.J.DAVIS,D.I.STUART,AUTH 2 E.Y.JONES,R.M.ESNOUFTITL THE LIGAND-BINDING FACE OF THE SEMAPHORINSTITL 2 REVEALED BY THE HIGH-RESOLUTION CRYSTAL STRUCTURETITL 3 OF SEMA4DREF NAT.STRUCT.BIOL. V. 10 843 2003REFN ISSN 1072-8368PMID 12958590DOI 10.1038/NSB977 Variant Set Distributions Ripley’s K […]
General Structure Information 4if6 SIRT1 structure of nad-dependent protein deacetylase sirtuin-1 (closed state, 2.25 a) 2.25Å AUTH A.M.DAVENPORT,F.M.HUBER,A.HOELZTITL STRUCTURE OF A NUCLEOPORIN COMPLEXREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants