General Structure Information
| PDB ID | 3s8i |
| HGNC Gene Label(s) | DDI1 |
| Structure Name | the retroviral-like protease (rvp) domain of human ddi1 |
| Resolution | 1.7Å |
| Reference | AUTH J.R.WALKER,A.ASINAS,A.DONG,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,S.DHE-PAGANON,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL RETROPEPSIN-LIKE DOMAIN OF HUMAN DDI1REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 124 |
| Number Of SNVs | 33 |
| Number Of Permutations | 9005 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.091 |
| p-value | 0.905 |
COSMIC
| Number Of Residues | 124 |
| Number Of SNVs | 10 |
| Number Of Permutations | 1926 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.244 |
| p-value | 0.019 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 33 |
| Number Of COSMIC SNVs | 9 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | -0.193 |
| p-value | 0.24 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
