General Structure Information
| PDB ID | 4if6 |
| HGNC Gene Label(s) | SIRT1 |
| Structure Name | structure of nad-dependent protein deacetylase sirtuin-1 (closed state, 2.25 a) |
| Resolution | 2.25Å |
| Reference | AUTH A.M.DAVENPORT,F.M.HUBER,A.HOELZTITL STRUCTURE OF A NUCLEOPORIN COMPLEXREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 277 |
| Number Of SNVs | 51 |
| Number Of Permutations | 37150 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.02 |
| p-value | 0.435 |
COSMIC
| Number Of Residues | 277 |
| Number Of SNVs | 3 |
| Number Of Permutations | 106 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | 0.333 |
| p-value | 0.811 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
