Assessment of Structural Intolerance and Durability
General Structure Information 1rtf PLAT complex of benzamidine with the catalytic domain of human two chain tissue plasminogen activator [(tc)-t-pa] 2.3Å AUTH D.LAMBA,M.BAUER,R.HUBER,S.FISCHER,R.RUDOLPH,AUTH 2 U.KOHNERT,W.BODETITL THE 2.3 A CRYSTAL STRUCTURE OF THE CATALYTICTITL 2 DOMAIN OF RECOMBINANT TWO-CHAIN HUMAN TISSUE-TYPETITL 3 PLASMINOGEN ACTIVATORREF J.MOL.BIOL. V. 258 117 1996REFN ISSN 0022-2836PMID 8613982DOI 10.1006/JMBI.1996.0238 Variant Set Distributions […]
General Structure Information 1lq8 SERPINA5 crystal structure of cleaved protein c inhibitor 2.4Å AUTH J.A.HUNTINGTON,M.KJELLBERG,J.STENFLOTITL CRYSTAL STRUCTURE OF PROTEIN C INHIBITOR PROVIDES INSIGHTSTITL 2 INTO HORMONE BINDING AND HEPARIN ACTIVATIONREF STRUCTURE V. 11 205 2003REFN ISSN 0969-2126PMID 12575940DOI 10.1016/S0969-2126(02)00944-9 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2uzp PRKCG crystal structure of the c2 domain of human protein kinase c gamma. 2.0Å AUTH A.C.W.PIKE,A.AMOS,C.JOHANSSON,F.SOBOTT,P.SAVITSKY,AUTH 2 G.BERRIDGE,O.FEDOROV,C.UMEANO,F.GORREC,G.BUNKOCZI,AUTH 3 J.DEBRECZENI,F.VON DELFT,C.H.ARROWSMITH,A.EDWARDS,J.WEIGELT,AUTH 4 M.SUNDSTROM,S.KNAPPTITL CRYSTAL STRUCTURE OF C2 DOMAIN OF PROTEIN KINASE C GAMMAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4f0x MLYCD crystal structure of human malonyl-coa decarboxylase (peroxisomal isoform) 3.29Å AUTH D.APARICIO,R.PEREZ-LUQUE,X.CARPENA,M.DIAZ,J.C.FERRER,AUTH 2 P.C.LOEWEN,I.FITATITL STRUCTURAL ASYMMETRY AND DISULFIDE BRIDGES AMONG SUBUNITSTITL 2 MODULATE THE ACTIVITY OF HUMAN MALONYL-COA DECARBOXYLASE.REF J.BIOL.CHEM. V. 288 11907 2013REFN ISSN 0021-9258PMID 23482565DOI 10.1074/JBC.M112.443846 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1afo GYPA dimeric transmembrane domain of human glycophorin a, nmr, 20 structures -1.0Å AUTH K.R.MACKENZIE,J.H.PRESTEGARD,D.M.ENGELMANTITL A TRANSMEMBRANE HELIX DIMER: STRUCTURE ANDTITL 2 IMPLICATIONS.REF SCIENCE V. 276 131 1997REFN ISSN 0036-8075PMID 9082985DOI 10.1126/SCIENCE.276.5309.131 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1hig IFNG three-dimensional structure of recombinant human interferon- gamma. 3.5Å AUTH S.E.EALICK,W.J.COOK,S.VIJAY-KUMAR,M.CARSON,AUTH 2 T.L.NAGABHUSHAN,P.P.TROTTA,C.E.BUGGTITL THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMANTITL 2 INTERFERON-GAMMA.REF SCIENCE V. 252 698 1991REFN ISSN 0036-8075PMID 1902591 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1hdz ADH1B three-dimensional structures of three human alcohol dehydrogenase variants: correlations with their functional differences 2.5Å AUTH T.D.HURLEY,W.F.BOSRON,C.L.STONE,L.M.AMZELTITL STRUCTURES OF THREE HUMAN BETA ALCOHOLTITL 2 DEHYDROGENASE VARIANTS. CORRELATIONS WITH THEIRTITL 3 FUNCTIONAL DIFFERENCES.REF J.MOL.BIOL. V. 239 415 1994REFN ISSN 0022-2836PMID 8201622DOI 10.1006/JMBI.1994.1382 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4gj7 REN crystal structure of renin in complex with nvp-bca079 (compound 12a) 2.8Å AUTH E.LORTHIOIS,W.BREITENSTEIN,F.CUMIN,C.EHRHARDT,E.FRANCOTTE,AUTH 2 E.JACOBY,N.OSTERMANN,H.SELLNER,T.KOSAKA,R.L.WEBB,D.F.RIGEL,AUTH 3 U.HASSIEPEN,P.RICHERT,T.WAGNER,J.MAIBAUMTITL THE DISCOVERY OF NOVEL POTENT TRANS-3,4-DISUBSTITUTEDTITL 2 PYRROLIDINE INHIBITORS OF THE HUMAN ASPARTIC PROTEASE RENINTITL 3 FROM IN SILICO THREE-DIMENSIONAL (3D) PHARMACOPHORETITL 4 SEARCHES.REF J.MED.CHEM. V. 56 2207 2013REFN ISSN 0022-2623PMID 23425156DOI 10.1021/JM3017078 […]
General Structure Information 1gbn OAT human ornithine aminotransferase complexed with the neurotoxin gabaculine 2.3Å AUTH S.A.SHAH,B.W.SHEN,A.T.BRUNGERTITL HUMAN ORNITHINE AMINOTRANSFERASE COMPLEXED WITH L-CANALINETITL 2 AND GABACULINE: STRUCTURAL BASIS FOR SUBSTRATE RECOGNITION.REF STRUCTURE V. 5 1067 1997REFN ISSN 0969-2126PMID 9309222DOI 10.1016/S0969-2126(97)00258-X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2x0b AGT crystal structure of human angiotensinogen complexed with renin 4.33Å AUTH A.ZHOU,R.W.CARRELL,M.P.MURPHY,Z.WEI,Y.YAN,P.L.STANLEY,AUTH 2 P.E.STEIN,F.B.PIPKIN,R.J.READTITL A REDOX SWITCH IN ANGIOTENSINOGEN MODULATES ANGIOTENSINTITL 2 RELEASE.REF NATURE V. 468 108 2010REFN ISSN 0028-0836PMID 20927107DOI 10.1038/NATURE09505 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants